ATS 2019 Virtual Final Program

BASIC • CLINICAL • TRANSLATIONAL THEMATIC POSTER SESSION A62 MUCUS, MUCINS, MUCOCILIARY UNIT IN LUNG DISEASE 9:15 a.m. - 4:15 p.m. KBHCCD Area C (Hall F, Level 2) Viewing: Posters will be on display for entire session. Discussion: 11:15-12:00: authors will be present for individual discussion 12:00-1:00: authors will be present for discussion with assigned facilitators. Facilitator : W.J. Janssen, MD, Denver, CO P342 Deficiency of Autophagy Regulatory Proteins Increase Airway Epithelial Secretory Mucins MUC5AC and MUC5B/ J.D. Dickinson, J. Sweeter, B.F. Dickey, S.L. Brody, Omaha, NE, p.A2143 P343 Allethrin and Prallethrin Stimulates MUC5AC Expression Through Oxidative Stress in Human Airway Epithelial Cells/ H.G. Na, Y.S. Choi, C.H. Bae, S.-Y. Song, S. Kwak, Y.-D. Kim, Daegu, Korea, Republic of, p.A2144 P344 Chronic Alcohol Exposure Reduces Airway Secretory MUC5AC Levels in a Post-TRANSLATIONAL Fashion in Human Airway Epithelial Cells/ R. Hooten, J. Sweeter, J.H. Sisson, J.D. Dickinson, Omaha, NE, p.A2145 P345 Resistin Upregulates MUC5AC/B Mucin Gene Expression in Human Airway Epithelial Cells/ Y.S. Choi, S. Kwak, H.G. Na, S.-Y. Song, C.H. Bae, Y.-D. Kim, Daegu, Korea, Republic of, p.A2146 P346 Endoplasmic Reticulum Stress Induces MUC5AC and MUC5B Expression in Human Nasal Airway Epithelial Cells/ Y.-D. Kim, Y.S. Choi, H.G. Na, C.H. Bae, S.-Y. Song, S. Kwak, Daegu, Korea, Republic of, p.A2147 P347 Galectin-3 Modulation of MUC5AC and MUC5B/ M.J. Mammen, D.E. Sykes, K. Cwiklinski, R. Aalinkeel, S. Schwartz, M. Sands, S. Mahajan, Buffalo, NY, p.A2148 Facilitator : C.M. Evans, PhD, Aurora, CO P348 Genome-Wide Association Study of Sputum Mucin Concentrations in the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS)/ S.N. Kelada, Y. Li, E. van Buren, G. Radicioni, A. Ford, W.K. O’Neal, V.E. Ortega, P. Woodruff, E.R. Bleecker, R.C. Boucher, M. Kesimer, Chapel Hill, NC, p.A2149 P349 Suitable Reference Gene Determination for Real Time Polymerase Chain Reaction (PCR) Using Induced Sputum Samples/ C. Moermans, E. Deliege, D. Pirottin, C. Poulet, J. Guiot, M. Henket, J. Da Silva, R. Louis, Liege, Belgium, p.A2150 P350 AC6 Regulates Microtubule-Depolymerizing Kinesin Kif19a for Ciliary Length Control in Mammals/ K. Arora, Cincinnati, OH, p.A2151 P351 Improved Expansion of Primary Normal and Cystic Fibrosis Human Airway Epithelial Cells Using PneumaCult™-Ex Plus, a Novel BPE- and Feeder-Free Medium That Promotes Maintenance of Their Mucociliary Differentiation Potential in Later Passages/ J. Hou, T. Brown, A. Yoshikawa, M. Soo, J. Stingl, T.E. Thomas, A. Eaves, S.A. Louis, Vancouver, Canada, p.A2152 P352 Mechanisms of Military Deployment-Related Lung Diseases: Desert Dust Exposure Induces Epidermal Differentiation of Both Human Airway Epithelial Stem Cells and the Mucociliary Airway Epithelium/ J.L. Everman, N.D. Jackson, B. Saef, K. Li, C. Rios, M.T. Montgomery, C.S. Rose, B.J. Day, H.W. Chu, G.P. Downey, M.A. Seibold, Denver, CO, p.A2153 P353 In Vitro Characterization of the Anti-Jagged-1 Antibody AMG 430 Using Human Airway Organoid Cultures to Study the Role of Jagged-1 in Normal and Diseased Human Airway Epithelial Cell Differentiation/ B.D. Bennett, J. Whoriskey, T. Buber, P. Rathanaswami, J.E. Phillips, J.J.A. Johnston, Thousand Oaks, CA, p.A2154 Facilitator : V. Kim, MD, ATSF, Philadelphia, PA P354 Amphiregulin Potentiates Airway Inflammation and Mucushypersecretion Induced by Urban Particulate Matter Via the EGFR-PI3Ka-AKT/ERK Pathway/ J. Wang, M. Zhu, Y. Song, Shanghai, China, p.A2155 P355 Mucociliary Transport In Vitro: Effect of Mucin Concentration, Reducing Agents, and DNA on Rheological Properties and Transport Rate/ L.E. Ostrowski, P.R. Sears, M. Markovetz, H. Gong, D.B. Hill, Chapel Hill, NC, p.A2156 P356 VAMP3 Is a v-SNARE in Baseline Mucin Secretion/ O. Hoang, Z. Azzegagh, C. Garcia, J.R. Flores Gonzalez, A.M. Jaramillo, M.J. Tuvim, B.F. Dickey, Houston, TX, p.A2157 P357 Syntaxin 3 Mediates Baseline Mucin Secretion/ J.R. Flores Gonzalez, A. Kushwaha, C. Kernell, M. Bleckhman, O.N. Hoang, A.M. Jaramillo, M.J. Tuvim, B.F. Dickey, Houston, TX, p.A2158 P358 Muc5b and Other Genes Predispose Mice to Lung Fibrosis/ A.M. Estrella, E. Dobrinskikh, C.E. Hennessy, I.V. Yang, D.A. Schwartz, Aurora, CO, p.A2159 P359 The Proline-Rich Domain of p53 Protects from Mucin Gene Expression at Baseline and After Short-Term but Not Chronic Wood Smoke Exposures/ D. Tassew, Y. Tesfaigzi, Albuquerque, NM, p.A7330 P360 Balancing the Immune Response in Cystic Fibrosis: Using Zebrafish Models of Inflammation to Uncover New Therapeutic Approaches/ S.A. Renshaw, A. Floto, A. Bernut, Sheffield, United Kingdom, p.A7331 P361 Circulating Mitochondrial DNA Is Associated with Acute Exacerbations of Cystic Fibrosis/ V. Ortiz, C. Ryu, E. Herzog, C.J. Britto-Leon, J. Koff, New Haven, CT, p.A7332 P362 Epigenome Wide DNA Methylation Analysis of Bronchoalveolar Lavage as a Predictor of Lung Disease Severity in Cystic Fibrosis; A Pilot Study/ S. Shanthikumar, J. Maksimovic, P. Rao, M. Neeland, R. Saffery, S.C. Ranganathan, Parkville, Australia, p.A7333 ATS 2019 • Dallas, TX 82 SUNDAY • MAY 19