ATS 2019 Virtual Final Program

Facilitator : E. Plosa, MD, Nashville, TN P315 Inhibition of Cyclin G-Associated Kinase (GAK) Impairs Growth of Alveolar Type 2 Cells in a 3-Dimensional Culture System/ C.A. Bates, B. Zhao, A. Schlobohm, C. Asquith, W. Zuercher, C.E. Barkauskas, Durham, NC, p.A2125 P316 Glucocorticoid-Driven Transcriptomes in Human Airway Epithelial Cells: Commonalities, Differences and Functional Insight from Cell Lines and Primary Cells/ M.M. Mostafa, C.F. Rider, R. Newton, Calgary, Canada, p.A2126 P317 Modulation of TMEM16B Channel Activity by the Calcium-Activated Chloride Channel Regulator 4 Suggests a Common Function for CLCA Proteins in Modifying TMEM16 Channels/ T. Brett, M. Sala-Rabanal, K. Berry, D.F. Steinberg, C.G. Nichols, St. Louis, MO, p.A2127 P318 Gymnotic Uptake of Oligonucleotides Alter MicroRNA Levels in Normal Human Bronchial Epithelial and THP-1 Cells/ S.C. Ramelli, S. Alsaaty, J. Sun, A.F. Suffredini, Bethesda, MD, p.A2128 P319 The Role of Placental Growth Factor as a Mediator of Pulmonary Disease Via Human Alveolar Type 2 Pneumocyte Apoptosis/ E. Simpson, A.D. Rice, T. Wang, M.B. Fallon, Phoenix, AZ, p.A2129 P320 Respiratory Epithelial Cell Regulation of Pulmonary Immune Surveillance/ G. Bandyopadhyay, H.L. Huyck, S. Bhattacharya, R. Misra, J. Lillis, J. Myers, S. Romas, J. Holden-Wiltse, J. Ashton, T.J. Mariani, G.S. Pryhuber, Rochester, NY, p.A2130 P321 Investigating How Podoplanin Expression Can Be Used to Identify Basal Cells in Human Proximal Airways/ S. Clarke, K. Gowers, S. Janes, London, United Kingdom, p.A2131 P322 Jianpiyifei II Granule Suppresses Cigarette Smoke Extract-Induced Apoptosis in Bronchial Epithelial Cells via Inhibition of Endoplasmic Reticulum Stress/ L. Fan, L. Li, X.H. Yu, L. Wu, Y.B. Chen, Y.J. Xu, L. Lin, Guangzhou, China, p.A2132 P323 Complement Component C3 Modulates Airway Epithelial Stress Through Receptor-Dependent and Independent Mechanisms/ H.S. Kulkarni, L. Ma, X. Wu, S.P. Gunsten, M. Elvington, S.L. Brody, J. Atkinson, St. Louis, MO, p.A2133 Facilitator: T. Parimon, MD, Los Angeles, CA P324 Selective Activation of Angiotensin Type 2 (AT2) Receptor Protects Alveolar Epithelial Cells Against Bleomycin-Induced Injury/ R. Alcaraz, A. Shenoy, U. Steckelings, M. Katovich, C. Sumners, V. Shenoy, Clovis, CA, p.A2134 P325 HECT E3 Ubiquitin Ligase Smurf2 Regulates µ-Opioid Receptor Degradation in Lung Epithelial Cells/ Y. Zhao, S. Dong, J. Liu, J. Zhao, Columbus, OH, p.A2135 P326 Delivery of Synthetic Oligonucleotide Vectors to Lung Epithelial Cells by Vibration Mesh Nebulisation/ S. McCarthy, C. Masterson, R. MacLoughlin, C. Rohde, M. Angel, J.G. Laffey, D. O’Toole, Galway, Ireland, p.A2136 P327 Dynamin Related Protein 1-Mediated Mitochondrial Fission Regulates the Lung Epithelial Response to Allergen/ S. Bruno, B. Korwin-Mihavics, A. Kumar, Z. Mark, B. Cunniff, V. Anathy, Burlington, VT, p.A2137 P328 ATP-Citrate Lyase Controls Oxygen Consumption Rate and DNA Repair Responses in Alveolar Epithelial Cells/ H. Shaghaghi, R. Para, D.J. Sales, F. Romero, R.S. Summer, Philadelphia, PA, p.A2138 P329 Dexamethasone Induces Senescence in A549 Cells: Relevance to Pulmonary Fibrosis/ F. Longhorne, H.N. Wilkinson, M.J. Hardman, S. Hart, Cottingham, United Kingdom, p.A2139 P330 Development of a Human in Vitro Model of Lung Epithelial Senescence Highlights the Cell-Type Specific Response to Telomere Dysfunction/ D. Sullivan, M.G. Roth, J.K. Alder, Pittsburgh, PA, p.A2140 P331 In Vitro Studies on the Impact of Ergothioneine on Idiopathic Pulmonary Fibrosis Markers in Human Lung Epithelial Cells/ C.C. Koay, M.A. Selo, C.G. Clerkin, C. Ehrhardt, Dublin, Ireland, p.A2141 P332 Organic Components of Air Pollution Particulate Matter 2.5 (PM2.5) Elicit Changes in the Airway Epithelial Transcriptome of Asthmatic Children/ M. Cromie, B. Saef, M.T. Montgomery, C. Rios, S.-H. Cho, J.L. Everman, V. Medina, S. Oh, C. Eng, J.R. Rodriguez-Santana, E.G. Burchard, M.A. Seibold, Denver, CO, p.A2142 Facilitator : S.H. Randell, PhD, Chapel Hill, NC P333 Unjamming and Energy Metabolism in the Epithelial Layer/ S. DeCamp, N.C. Ogassavara, J.J. Fredberg, Boston, MA, p.A7322 P334 Phosphatase Shp2 Modulate Epithelial Exosomes in ALI : Evidence of Macrophage Activation/ Y. Li, Y. Zhang, H. Chen, X. Zhang, Y. Ke, Hangzhou, China, p.A7323 P335 Insights into Glucocorticoid Resistance: Synergy Between Glucocorticoids and Inflammatory Cytokines on TLR2 Expression/ A. Bansal, M.M. Mostafa, S. Shah, C. Kooi, R. Leigh, A.N. Gerber, R. Newton, Calgary, Canada, p.A7324 P336 Transforming Growth Factor Beta Regulates Epithelial Cell Death During Influenza Infection/ K.S. Hong, H.S. Yun, R. Harris, A.M.K. Choi, H. Stout-Delgado, S.J. Cho, New York, NY, p.A7325 P337 Interleukin-6 Is Required for Neuregulin-1 Induced HER2 Signaling in Pulmonary Epithelial Cells/ R. Mishra, D.G. Foster, J.H. Finigan, J.A. Kern, Denver, CO, p.A7326 P338 Hyperoxic Exposure Increases Senescence in Type II-Like Mouse Lung Epithelial Cells: Role of P53 Signaling/ A. Scaffa, A. Peterson, P.A. Dennery, Providence, RI, p.A7327 P339 Preserved Ciliary Defects in Airway Epithelia Derived from Primary Ciliary Dyskinesia Basal Cells Expanded in 3T3-J2 Co-Culture/ R. Hynds, D. Do Hyang Lee, D. Cardinale, E. Nigro, C. Butler, A. Rutman, R.A. Hirst, S.L. Hart, H. Mitchison, S.M. Janes, C. O’Callaghan, London, United Kingdom, p.A7328 P340 Recapitulating Epithelial Dysfunction in the Context of Idiopathic Pulmonary Fibrosis Using an iPSC Derived Air-Liquid Interface Model of Alveolar Epithelial Differentiation/ J.P. Garnett, V. Schroeder, H.L. Quang, M.J. Webster, E.L. Stewart, D. Raedel, R. Heiker, M. Dass, K. Quast, M. Frick, E. Schruf, Biberach an der Riss, Germany, p.A7329 ATS 2019 • Dallas, TX SUNDAY • MAY 19 81 SUNDAY MORNING