ATS 2019 Virtual Final Program

BASIC • CLINICAL • TRANSLATIONAL THEMATIC POSTER SESSION A63 PATHOPHYSIOLOGY OF ASTHMA IN CELLS, TISSUES, AND ANIMAL MODELS 9:15 a.m. - 4:15 p.m. KBHCCD Area E (Hall F, Level 2) Viewing: Posters will be on display for entire session. Discussion: 11:15-12:00: authors will be present for individual discussion 12:00-1:00: authors will be present for discussion with assigned facilitators. Facilitator : G. Ijpma, PhD, Montreal, Canada P739 Preservation of Contractility after Cryopreservation of Isolated Airway Smooth Muscle/ G. Ijpma, Q.C. Liang, L.H. Kachmar, A. Panariti, A. Benedetti, J.-P. Lavoie, A.-M. Lauzon, Montreal, Canada, p.A2160 P740 The Elapsed Time Between Simulated Deep Inspirations on the Mechanics of Airway Smooth Muscle in Ovine Tracheal Strips/ F. Khadangi, M. Gazzola, M. Clisson, J. Beaudoin, M.-A. Clavel, Y. Bossé, Quebec, Canada, p.A2161 P741 Effect of Stretch on Hyaluronan Expression and Signaling in Developing Human Airway Smooth Muscle/ J. Teske, L. Manlove, A. Orakwue, A.M. Roesler, Y.S. Prakash, P. MacFarlane, C.M. Pabelick, Rochester, MN, p.A2162 P742 Tracheal Smooth Muscle Relaxation Produced by Phosphodiesterase Inhibitors ( Sildenafil and Ordonofil) Compared to That of Theophylline/ S.Y. Khatib, M.M. Al Janabi, Irbid, Jordan, p.A2163 P743 Extracellular Matrix Stiffness Regulates Force Transmission Pathways in Multicellular Ensembles of Human Airway Smooth Muscle Cells/ S.R. Polio, S.E. Stasiak, R. Krishnan, H. Parameswaran, Boston, MA, p.A2164 P744 Extracellular Matrix Regulates Calcium Oscillations in Multicellular Ensembles of Airway Smooth Muscle Cells/ S.E. Stasiak, H. Parameswaran, Boston, MA, p.A2165 Facilitator : A.A. Zeki, MD, Davis, CA P745 Benzbromarone Decreases Agonist-Induced MLC Phosphorylation While Also Enhancing cAMP Signaling Pathways/ G. Cao, B.T. Deeney, R.A. Panettieri, New Brunswick, NJ, p.A2166 P746 Proprotein Convertase PACE4 Modulates Basal Progenitor Cell Fate in IL-4-Stimulated Human Nasal Epithelial Cells/ S.-N. Lee, J.-S. Ahn, S. Kim, J.G. Ha, J.-H. Yoon, Seoul, Korea, Republic of, p.A2167 P747 Ambrosia Psilostachya Pollen Induces the Proliferative Secretory Phenotype of Airway Smooth Muscle Cells and Inhibits MicroRNA-106b-25 Expression/ M.A. Ba, C. Adajar, C.A. Singer, Reno, NV, p.A2168 P748 Calcium-Sensing Receptor Contributes to Hyperoxia-Induced Enhancement of Calcium Regulation and Remodeling in Human Fetal Airway Smooth Muscle/ A.M. Roesler, C.M. Pabelick, R. Martin, P. MacFarlane, Y.S. Prakash, Rochester, MN, p.A2169 P749 Statin Drug Lipophilicity Affects Airway Epithelial Distribution: Not All Statins Are Created Equal/ A.A. Zeki, K. Chmiel, O. Fiehn, Davis, CA, p.A2170 P750 Differentiating Bronchial Epithelial Cells from Patients with Asthma Display Prolonged Repair and Delayed Barrier Formation/ N.F. Li, A.T. Reid, K.S. Nichol, C. Grainge, P.A.B. Wark, D.A. Knight, N.W. Bartlett, Newcastle, Australia, p.A2171 Facilitator : C.A. Singer, PhD, Reno, NV P751 TNF a Increases Mitochondrial Biogenesis in Human Airway Smooth Muscle/ N. Marin Mathieu, X. Chen, P. Delmotte, G.C. Sieck, Rochester, MN, p.A2172 P752 TNF a Induces Endoplasmic Reticulum Stress in Human Airway Smooth Muscle Cells/ J. Yap, X. Chen, P. Delmotte, N. Mathieu Marin, G.C. Sieck, Rochester, MN, p.A2173 P753 Kisspeptins Expression and Function in Asthmatic Human Airway Smooth Muscle/ N.A. Borkar, R.S.R. Kalidhindi, N.S. Ambhore, J. Loganathan, C.M. Pabelick, Y.S. Prakash, V. Sathish, Fargo, ND, p.A2174 P754 Smart Therapy: Why Is It Smart?/ S. Orfanos, G. Cao, B. Deeney, C. Koziol-White, R.A. Panettieri, New Brunswick, NJ, p.A2175 P755 Integrin Alpha2Beta1 Transmits Tension in Smooth Muscle via Interaction with Collagen and Laminin/ S. Liu, D. Sheppard, A.B. Sundaram, San Francisco, CA, p.A2176 P756 Interleukin-17A and Transforming Growth Factor-ß1 Dysregulate miR-25 Expression and Modulate Contractility in 3D-Printed Airway Rings/ M. O’Brien, J. Evasovic, M.A. Ba, C.A. Singer, Reno, NV, p.A2177 Facilitator : C.M. Pabelick, MD, Rochester, MN P757 Proteostasis and Senescence in the Aging Lung/ S.A. Wicher, A.M. Roesler, L. Manlove, B. Roos, Y.S. Prakash, C.M. Pabelick, Rochester, MN, p.A2178 P758 Oxygen Exposure and Circadian Biology in the Premature Developing Airway/ C.M. Bartman, R.D. Britt, L. Manlove, S.A. Wicher, A.M. Roesler, J.J. Teske, C.M. Pabelick, Y.S. Prakash, Rochester, MN, p.A2179 P759 Hyperoxia-Induced Soluble Guanylyl Cyclase (sGC) Dysfunction in Developing Airway Involves the Calcium Sensing Receptor (CaSR)/ J. Ravix, R.D. Britt, A.M. Roesler, S.A. Wicher, L. Manlove, M. Thompson, C.M. Pabelick, Y.S. Prakash, Rochester, MN, p.A2180 P760 Intrauterine Growth Restriction Mediates an Inflammatory Phenotype in Offspring but Does Not Affect Airway Epithelial Tight Junction Expression/ K.C.W. Wang, K. Looi, A. Kicic, P.B. Noble, Crawley, Australia, p.A2181 P761 Inhaled Budesonide Promotes Barrier Integrity In Vivo in a Mouse Model of Epithelial Barrier Disruption/ C. Rimmer, S.N. Georas, J. Veazey, Rochester, NY, p.A2182 P762 The Bronchodilator and Nutraceutical Ginger Reduces Lung Inflammation in a Murine Asthma Model/ J. Hwang, C.W. Emala, G.T. Yocum, New York, NY, p.A2183 ATS 2019 • Dallas, TX SUNDAY • MAY 19 83 SUNDAY MORNING