ATS 2019 Virtual Final Program

P291 Endothelial Metabolic Profiling of Ventilation Associated Mechanical Stress/ Y. Zhang, Y. Zhang, X. Shi, A. Rice, S. Wang, H. Gu, T. Wang, Phoenix, AZ, p.A2106 Facilitator : A. Schwingshackl, MD, PhD, Los Angeles, CA P292 MicroRNA-33 Regulates Inflammation and Fibrosis in the Injured Lung/ F. Zhao, J. Madenspacher, W.-C. Lin, M.B. Fessler, Research Triangle Park, NC, p.A2107 P293 Role of UCHL1 in Radiation-Induced Lung Injury Mediated by Sphingolipids/ Y. Epshtein, H. Wang, J.R. Jacobson, Chicago, IL, p.A2108 P294 Deficient of Deubiquitinating Enzyme USP13 Aggravates LPS-Induced Pulmonary Inflammation in Mice/ L. Li, J. Wei, S. Li, A. Jacko, N.M. Weathington, R.K. Mallampalli, J. Zhao, Y. Zhao, Columbus, OH, p.A2109 P295 Lentivirus-Mediated Overexpression of Mitochondrial Aldehyde Dehydrogenase (ALDH2) in H441 Cells Protects Against Hyperoxia Induced Mitochondrial Dysfunction/ R. Soundararajan, H. Hernandez-Cuervo, A. Bulki, A. Czachor, S. Srinivas, S.S. Patil, M. Varanasi, M. Alleyn, L. Galam, R.F. Lockey, N.V. Kolliputi, Tampa, FL, p.A2110 P296 Mechanistic Role of Cytochrome P450 (CYP)1 Family in Hyperoxia-Mediated Lung Toxicity: Novel Function of the Endogenous Ah Receptor Ligand 6-Formyllindolo[3,2-b]Carbazole (ficz) in Cyp1 Induction and Hyperoxic Injury/ B. Moorthy, A. Veith, L. Wang, W. Jiang, Houston, TX, p.A2111 P297 Detection of Mitochondrial Oxidative Phosphorylation Variants in Cell-Free Plasma Using Next-Generation Sequencing/ R.J. Langley, V.M. Pastukh, C.M. Francis, G. Daly, C. Edwards, Y. Tan, J.D. Simmons, M.N. Gillespie, Mobile, AL, p.A2112 P298 Curcumin Suppresses the Alveolar Inflammation and Modulates the p53-Fibrinolytic System and Epithelial to Mesenchymal Transition During Lung Injury and Fibrosis In Vitro and In Vivo/ S. Shaikh, A. Prabhu, M. Manjunath Gouda, P. Subba, M.A. Najar, P.K. Modi, Y. Prabhakar Bhandary, Mangalore, India, p.A2113 P299 Immunomodulation Properties of a Novel ß-Glucan Extract from the Mushroom Lentinus Edodes in an In-Vitro Lung Injury Model/ E.J. Murphy, C. Masterson, E. Rezoagli, D. O’Toole, J.G. Laffey, I. Major, G. Stack, N. Rowan, Athlone, Ireland, p.A2114 P300 Club Cell Specific Heme Oxygenase-1 Deletion Does Not Alter Hyperoxic Sensitivity In Adult Mice/ K. Dunigan, Q. Li, T. Nicola, C. Aegerter, R. Li, S. Wall, A. Agarwal, P. Vitiello, T.E. Tipple, Birmingham, AL, p.A2115 P301 Cyclophilin A as a Novel Mediator in Acute Lung Injury/ M.W. Koh, M. Takata, M.R. Wilson, London, United Kingdom, p.A7318 P302 Glutaredoxin-1 Mediated S-Glutathionylation Attenuates Acute Lung Injury/ Y. Guo, S. Zhao, H. Cheng, X. Zhang, Y. Ke, Hangzhou, China, p.A7319 P303 Evidence of Keratin 5 Positive Distal Airway Epithelial Cell Expansion in a Nonhuman Primate Model of Bleomycin-Induced Lung Injury/ L.A. Miller, A.E. Engler, A. Rindy, M.G.A. dela Pena-Ponce, H.A. Chapman, D.N. Kotton, J.R. Rock, Davis, CA, p.A7320 P304 Differential Impact of Co-Expressed SP-A1 and SP-A2 Protein on AM miRNome/ N. Thorenoor, X. Zhang, J. Floros, Hershey, PA, p.A7321 BASIC • TRANSLATIONAL THEMATIC POSTER SESSION A61 EPITHELIAL BIOLOGY 9:15 a.m. - 4:15 p.m. KBHCCD Area C (Hall F, Level 2) Viewing: Posters will be on display for entire session. Discussion: 11:15-12:00: authors will be present for individual discussion 12:00-1:00: authors will be present for discussion with assigned facilitators. Facilitator : K.M. Ridge, PhD, Chicago, IL P306 Structural Composition and Signaling Pathways of Alveolar Epithelial TREK-1 Potassium Channels/ A. Schwingshackl, B. Lopez, C.M. Waters, A. Wei, R. Olcese, Los Angeles, CA, p.A2116 P307 Negligible Telomere-Independent Effect of Telomerase on Alveolar Epithelial Cells/ S. Han, N.S. Chandel, Chicago, IL, p.A2117 P308 Single-Cell RNA Sequencing of Aquaporin 5 (Aqp5)-Positive Epithelial Cells in Adult Mouse Lung Reveals Heterogeneity of Type I Cells and Facilitates Identification of Gprc5a as a Potential Novel Type I Cell Marker/ M. Horie, M. Sunohara, A. Castaldi, H. Wang, Y. Ji, F. Li, H. Kage, E.D. Crandall, P. Flodby, B. Zhou, Z. Borok, Los Angeles, CA, p.A2118 P309 Delayed Increases in Hyaluronan Following Ozone Exposure Associates with Alveolar Type 2 Cell Proliferation/ R.M. Tighe, A. Birukova, A. Schlobohm, C.E. Barkauskas, Durham, NC, p.A2119 P310 Widespread Sexual Dimorphism in the Transcriptome of Human Airway Epithelium in Response to Smoking/ C.X. Yang, H. Shi, I. Ding, C.W.T. Yang, D.D. Sin, M. Obeidat, Vancouver, Canada, p.A2120 P311 Survival Mechanisms of Cells Following Chronic Expression of Aberrantly Trafficked ABCA3 Mutant Proteins: An In Vitro Study/ S. Mulugeta, M. Zhao, A. Venosa, Y. Tomer, M.F. Beers, Philadelphia, PA, p.A2121 P312 Calorie Restriction Can Reverse Several of the Aging and HFD-Induced Changes in Lung Epithelial Stem Cells/ M. Ozaki, A.E. Hegab, T. Betsuyaku, Tokyo, Japan, p.A2122 P313 Effects of Antioxidants on Inflammatory and Oxidative Stress Responses of Human Bronchial Epithelial Cells Co-Exposed to Particulate Matter and Cigarette Smoke Extract/ S.H. Jeong, E. Son, Y. Kim, J.-W. Park, S.Y. Kyung, Incheon, Korea, Republic of, p.A2123 P314 Evidence for Nanoparticle-Induced Lysosomal Dysfunction in Alveolar Epithelial Cells/ A. Sipos, K.J. Kim, Z. Borok, C. Sioutas, E.D. Crandall, Los Angeles, CA, p.A2124 ATS 2019 • Dallas, TX 80 SUNDAY • MAY 19