ATS 2019 Virtual Final Program

Facilitator : K.B. Hisert, MD, PhD, Seattle, WA P264 Cell-Free Hemoglobin Levels in the Distal Airspace of Patients with Acute Respiratory Distress Syndrome (ARDS) Are Associated with Markers of Lung Epithelial Injury, Airspace Inflammation, and Alveolar Permeability/ L. Habegger, J.B. McNeil, V.E. Kerchberger, L.B. Ware, C.M. Shaver, E.P. Schmidt, J.A. Bastarache, Nashville, TN, p.A2079 P265 Classically Activated Lung Macrophages Exacerbate Lower Respiratory Tract Infections/ J.L. Casey, L. Gu, V.B. Antony, D. Davis, A.B. Carter, Birmingham, AL, p.A2080 P266 Effects of Peritoneal Polymicrobial Infection on the Maturation and Function of Alveolar Macrophage and Therapeutic Effect of Intratracheal GM-CSF/ H. Tsuyuzaki, K. Uchida, T. Hiruma, Y. Tamai, Y. Yamada, Bunkyo-ku Hongo, Japan, p.A2081 P267 Peptide Transporter 2 (PEPT2) Is Involved in the Transport of Ac-PGP in the Lung/ S.W. Robison, J. Li, L. Viera, J.E. Blalock, X. Xu, A. Gaggar, Birmingham, AL, p.A2082 P268 The In Vivo Effects of Alcohol in Lung Are at Least Partially Mediated Through the Alpha 4 Nicotinic Acetylcholine Receptor/ J. Ritzenthaler, E. Torres-Gonzalez, G.E. Arteel, J. Roman Rodriguez, Philadelphia, PA, p.A2083 P269 Dimethyl Fumarate Potently Inhibits Thioredoxin Reductase 1 and Enhances Nrf2-Dependent Responses in Murine Club Cells/ T. Nicola, S. Wall, A. Lee, R. Li, W. Zhang, M. MacEwen, N. Ambalavanan, T.E. Tipple, Birmingham, AL, p.A2084 P270 Identification of the Ideal Mesenchymal Stem Cell Candidate to Treat Infection Induced Acute Respiratory Distress Syndrome In Vitro/ L. Alvarado, L. Rodriguez, A. Mohammadipoor, L.C. Cancio, B. Antebi, Ft. Sam Houston, TX, p.A2085 P271 Differential Protein Expression Profiles of Bronchoalveolar Lavage Fluid Following Lipopolysaccharide-Induced Direct and Indirect Lung Injury/ X. Yue, J. Guidry, New Orleans, LA, p.A2086 P272 Comparison of Biological Properties and Therapeutic Potential of Human Mesenchymal Stem Cells Derived from Bone Marrow and Chorionic Villi in Naphthalene-Induced Lung Injury Model/ S. Ji, C. Wu, Y. Song, Shanghai, China, p.A2087 P273 Ethyl Pyruvate Attenuates Ventilation-Induced Diaphragm Dysfunction Through High-Mobility Group Box-1 in a Murine Endotoxemia Model/ L.-F. Li, L.-C. Chiu, Taoyuan, Taiwan, p.A2088 Facilitator : J.A. Englert, MD, Columbus, OH P274 Nanobodies - A Novel Approach Designed to Target Plasminogen Activator Inhibitor 1/ A. Komissarov, M. Dacus, L. Naydanova, M. Sillen, P.J. Declerck, S. Idell, G. Florova, Tyler, TX, p.A2089 P275 Toll-Like Receptor 8 Is Activated by Circulating MicroRNA’s in Acute Respiratory Distress Syndrome/ J. Evankovich, T. Lear, J.D. Londino, C. Baldwin, T. Smail, Y. Liu, B.J. McVerry, R.K. Mallampalli, B. Chen, Pittsburgh, PA, p.A2090 P276 Prolonged LPS Exposure Caused Increased IL-1B Release in TREK-1 Deficient Macrophages Independent of NLRP3/ C.N. Immanuel, B. Teng, B. Dong, E. Gordon, C. Luellen, S. Cormier, E.A. Fitzpatrick, A. Schwingshackl, C.M. Waters, Los Angeles, KY, p.A2091 P277 Apoptosis Signal Regulating Kinase-1 (ASK1) Differentially Activates p38- and JNK-Mediated Inflammasome Pathways/ C.N. Immanuel, B. Teng, B. Dong, J. Tatum, E. Gordon, C. Luellen, A. Schwingshackl, E.A. Fitzpatrick, S. Cormier, C.M. Waters, Los Angeles, CA, p.A2092 P278 GAT107 Attenuates Hyperoxia-Induced Macrophage Dysfunction/ A. Gauthier, R. Sitapara, L. Mantell, Jamaica, NY, p.A2093 P279 The Study of BM-MSC in Regulating Function and Autophagy of Macrophages in Oxygen-Glucose Deprivation/Restoration Microenvironment/ N. Wang, C. Bai, Shanghai, China, p.A2094 P280 The NLRP3 Inflammasome Is a Critical Mediator of Cell-Free Hemoglobin-Induced Acute Lung Inflammation/ C.M. Shaver, S.R. Landstreet, S. Puganzethi, L.B. Ware, J.A. Bastarache, Nashville, TN, p.A2095 P281 Mechanisms of Human SP-B Genetic Variant Susceptibility and Sex Differences in Acute Lung Injury/ G. Wang, J. Zhang, Y. Fengyong, F. Ruan, O. Abdel-Razek, Syracuse, NY, p.A2096 P282 Novel Drug Based Therapy for Treatment of Vascular Leakage/ X. Qu, B. Hitchinson, A. Banerjee, S. Zhao, C. Zhang, V. Gaponenko, Y. Komarova, Chicago, IL, p.A2097 Facilitator : L. Mantell, MD, PhD, East Meadow, NY P283 Hypercapnia Decreases Function and Plasma Membrane Abundance of Na,K-ATPase by Inducing Carbonylation of Its ß-Subunit in Alveolar Epithelial Cells/ V. Kryvenko, W. Seeger, I. Vadász, Giessen, Germany, p.A2098 P284 PTP a Mediates Fibrotic Responses in Models of Fibroproliferative ARDS/ Y. Aschner, K.M. Beke, D.G. Foster, C.L. Meador, M.R. Nelson, H.M. Roybal, K.A. Correll, G.P. Downey, Aurora, CO, p.A2099 P285 Effects of High Dose Intravenous Vitamin C (IVC) on Plasma Cell-Free DNA Levels in Patients with Sepsis-Associated ARDS/ X. Qiao, B. Fisher, M.G. Kashiouris, J.D. Truwit, R.D. Hite, P.E. Morris, G.S. Martin, A.A. Fowler, Richmond, VA, p.A2100 P286 Identification and Characterization of miRNA-Rich Extracellular Vesicles in Bronchoalveolar Lavage Fluid/ H. Lee, Y. Jin, Boston, MA, p.A2101 P287 Downregulated Microrna-27b Attenuates Lipopolysaccharide-Induced Acute Lung Injury Via Activation of Nrf2 and Inhibition of NF- k B Signaling Pathways/ G. Zhu, Y. Huang, L. Huang, W. Zhang, Z. Pei, Beijing, China, p.A2102 P288 Aging Causes Distinct Transcriptional and Epigenetic States in Pro-Resolving T Cells/ B.D. Singer, K. Helmin, L. Morales-Nebreda, L. Niedernhofer, Chicago, IL, p.A2103 P289 Heparan Sulfate and the Fibroproliferative Response to Acute Lung Injury/ W.B. LaRiviere, S. McMurtry, S. Haeger, S. Liao, F. Zhang, R. Linhardt, E.P. Schmidt, Y. Yang, Aurora, CO, p.A2104 P290 Preconditioning in an Acute Respiratory Distress Syndrome-Like Milieu Augments the Immunomodulatory and Anti-Inflammatory Function of MSCS/ L. Rodriguez, A. Mohammadipoor, R.M. Kamucheka, A. Asher, L. Alvarado, B. Antebi, L. Cancio, Ft. Sam Houston, TX, p.A2105 ATS 2019 • Dallas, TX SUNDAY • MAY 19 79 SUNDAY MORNING