ATS 2019 Virtual Final Program

304 Usefulness of Plasmatic MiR-146a and MiR-16-5p as Prognostic Biomarkers in Community-Acquired Pneumonia/ J.M. Galvan Roman, A. Lancho, S. Luquero Bueno, L. Vega Piris, J. Curbelo, G. Mateos, M. Gomez, M. Ortega Gomez, J. Aspa, Madrid, Spain, p.A1204 305 MCP-1 Deficiency Enhances Susceptibility to Carbapenem-Resistant Klebsiella Pneumoniae Via Modulating Neutrophil and Macrophage Function/ L. Jin, S. Paudel, L. Ghimire, S. Cai, S. Jeyaseelan, Baton Rouge, LA, p.A1205 306 Pseudomonas Aeruginosa Infection Attenuates Expression of Critical Genes Responsible for Mitochondrial Biogenesis and Anti-Oxidant Defense in Murine Model of Acute Pneumonia/ N.M. Maurice, B. Bedi, Z. Yuan, J.B. Goldberg, C.M. Hart, R.T. Sadikot, Atlanta, GA, p.A1206 307 Neutrophils-Released SOCS3 Rectifies Phenotype of SOCS3-Deletion in Lung Epithelial Cells Facilitating Influenza Replication/ X. Su, L. Li, H. Wu, Q. Li, K. Xu, Shanghai, China, p.A1207 308 Aerosolized Toll-Like Receptor Agonists Suppress Acute Sendai Virus Burden and Chronic Asthma-Like Lung Disease in Mice/ D.L. Goldblatt, J.R. Flores Gonzalez, G. Valverde, A.M. Jaramillo, S. Tkachman, S. Wali, B. Hernandez, B. Scott, J. Chen, S.E. Evans, M.J. Tuvim, B.F. Dickey, Houston, TX, p.A1208 309 Bioorthogonal Amino Acid Labeling Reveals the Metabolically Active Subpopulation of the Cystic Fibrosis Lung Microbiota/ R.C. Hunter, K. Binder, T. Valentini, S.K. Lucas, L. Cameron, J.M. Dunitz, Minneapolis, MN, p.A1209 310 The Role of NLRP12 in Host Defense Against Legionella Pneumophila Infection/ S. Cai, L. Jin, S. Jeyaseelan, Baton Rouge, LA, p.A1210 311 Pneumococcal Phosphodiesterase 2 Mutation Elicits a Unique Type I Interferon Expression in Macrophages/ A.K. Wooten, A.T. Shenoy, E.I. Arafa, M.R. Jones, L.J. Quinton, S.I. Pelton, G. Bai, J.P. Mizgerd, Boston, MA, p.A1211 312 Experimental Modeling of Infectious Exacerbations in a Cigarette Smoke-Induced Ferret Model of COPD/ B.C. Hunt, D. Stanford, N. Kaza, S. Byzek, J. LaFontaine, S.M. Rowe, S.V. Raju, E. Swords, Birmingham, AL, p.A1212 313 Transcriptional Remodeling of Recruited Neutrophils During Pneumococcal Pneumonia/ K. Traber, E. Symer, Y. Kim, M.R. Jones, J.P. Mizgerd, L.J. Quinton, Boston, MA, p.A1213 314 Remodeling and Reprogramming of Tissue-Resident Alveolar Macrophages After Recovery of Lung Infection/ A. Guillon, E.I. Arafa, K.A. Barker, A. Belkina, I.M.C. Martin, A.T. Shenoy, A.K. Wooten, C. Lyon De Ana, J. Hernandez Escalante, H. Dooms, K. Traber, M.R. Jones, L.J. Quinton, J.P. Mizgerd, Boston, MA, p.A1214 315 Lymphocyte Landscape of Heterotypic Immune Murine Lungs/ C. Lyon De Ana, A.T. Shenoy, K. Barker, M.R. Jones, L.J. Quinton, J.P. Mizgerd, Boston, MA, p.A1215 316 Lung Epithelial PDIA3 Plays a Critical Role in Influenza infection/ N. Chamberlain, B. Korwin-Mihavics, E. Nakada, S. Bruno, D. Heppner, D.G. Chapman, S.M. Hoffman, A. Van Der Vliet, B.T. Suratt, O. Dienz, J.F. Alcorn, V. Anathy, Burlington, VT, p.A1216 317 The Elucidation of Pathogenicity of Carbapenemase-Producing Klebsiella Pneumoniae Pulmonary Infection Using Single Cell RNAseq/ N. Iwanaga, I. Sandquist, Y. Doi, K. Song, A. Wanek, C. Flemington, J.K. Kolls, New Orleans, LA, p.A1217 318 Signature Bacteria of Lower Airway Dysbiosis Activate TLR4 and Inflammasome Pathways in Airway Epithelial Cells/ E. Olsen, L. Perez, B. Franca, Y. Li, J. Carpenito, M. Osborne, B. Wu, L.N. Segal, J. Tsay, New York, NY, p.A1218 319 Phosphorothiorate Oligonucleotide Stimulated Mitochondrial Reactive Oxygen Species Mediate Lung Epithelial Innate Resistance to Bacterial Infection/ Y. Wang, M. Leiva-Juarez, V. Kulkarni, J. Pantaleon-Garcia, S. Wali, S.E. Evans, Houston, TX, p.A1219 320 Francisella Induced Microparticulate Caspase-1/Gasdermin-d Activation Is Regulated by NLRP3 Independent of Pyrin/ S. Das, E. Dolvin, K. Krishnamurthy, M.D. Wewers, A. Sarkar, Columbus, OH, p.A1220 321 Expression of LOX-1 in the Lung Modulates Acute Pulmonary Inflammation During Pneumonia/ F.T. Korkmaz, E. Symer, C. Odom, W. Molina, E. Na, L. Baird, Y. Kim, M.R. Jones, J.P. Mizgerd, K. Traber, L.J. Quinton, Boston, MA, p.A1221 322 Purified Beta-Glucan from the Lentinus Edodes Mushroom Attenuates Antibiotic Resistant Klebsiella Pneumoniae-Induced Pulmonary Sepsis/ C.H. Masterson, E. Murphy, I. Major, H. González, D. O’Toole, S. McCarthy, J.G. Laffey, N. Rowan, Galway, Ireland, p.A1222 323 Pseudomonas Aeruginosa Type 2 Secretion System Exoproducts Induce Murine Lung Epithelial Cell Death In Vitro/ M. Yu, W.G. Bain, R.M.Q. Shanks, Z. Cheng, G.A. Gibson, C.M. St. Croix, J.S. Lee, Pittsburgh, PA, p.A1223 324 Interactions Between Klebsiella Pneumoniae and the Host Lung Environment in Murine Obesity Models/ G. Euceda, M. Wargo, B.T. Suratt, Burlington, VT, p.A1224 325 Chitinase 3 Like 1 Protein Promotes Host Tolerance During Lung Infection with Influenza Viral Infection/ A.P. Rebaza, C. Dela Cruz, L.K. Sharma, New Haven, CT, p.A7300 BASIC • TRANSLATIONAL POSTER DISCUSSION SESSION A29 EMERGING CONCEPTS IN LUNG FIBROSIS 9:15 a.m. - 11:15 a.m. KBHCCD Ballroom D Four (Level 3) Poster Viewing 9:15-10:00 Discussion 10:00-11:15 Chairing: J.S. Hagood, MD, Chapel Hill, NC E.F. Redente, PhD, Denver, CO A. Lam, MD, Chicago, IL ATS 2019 • Dallas, TX 42 SUNDAY • MAY 19