ATS 2019 Virtual Final Program

701 Inhalation of Lung Spheroid Cell-Secretome and Exosomes Promotes Therapeutic Lung Repair in Rodent Models of Pulmonary Fibrosis/ P.U.C. Dinh, D. Paudel, H. Brochu, J. Cores, K. Huang, M.T. Hensley, E. Harrell, A. Vandergriff, R. Barrio, T.A. Allen, K. Blackburn, T.G. Caranasos, X. Peng, L.V. Schnabel, K.B. Adler, L. Lobo, M.B. Goshe, K. Cheng, Raleigh, NC, p.A1225 702 Local Delivery of NOX4 Antisense Oligonucleotides Ameliorate Established Fibrosis in a Bleomycin-Induced Model of IPF/ C. Zhao, J.R. Crosby, D. Bai, M. Zhang, A. Bell, A.R. MacLeod, S. Guo, Carlsbad, CA, p.A1226 703 Effective Anti-Fibrotic Therapy for Hermansky-Pudlak Syndrome Pulmonary Fibrosis in Pale Ear Mice Using a Hybrid Inhibitor of Cannabinoid Receptor 1 (CB1R) and Inducible Nitric Oxide Synthase (iNOS), MRI-1867/ R. Cinar, N.J. Coffey, S. Bodine, J.K. Park, M.R. Iyer, B.R. Gochuico, W.A. Gahl, M.C.V. Malicdan, G. Kunos, Rockville, MD, p.A1227 704 Repurposing an Opioid Receptor Antagonist as a Treatment for Idiopathic Pulmonary Fibrosis/ D. Soundararajan, S.K. Madala, A. Jegga, Cincinnati, OH, p.A1228 705 Increased Flux Through the Mevalonate Pathway Mediates Fibrotic Repair Without Injury/ J.L. Casey, M. Vaid, L. Gu, C. He, G.-Q.C. Cai, Q. Ding, D. Davis, T.F. Berryhill, L.S. Wilson, S. Barnes, J.D. Neighbors, R.J. Hohl, R. Surolia, V.B. Antony, V.S. Hanumanthu, A.B. Carter, Birmingham, AL, p.A1229 706 Monocyte-Derived Alveolar Macrophages Drive Enhanced Susceptibility to Non-Resolving Pulmonary Fibrosis During Aging/ S. Watanabe, N. Joshi, R. Verma, R.P. Aillon, C.-I. Chen, D.W. Kamp, G.R.S. Budinger, A.V. Misharin, Chicago, IL, p.A1230 707 Myeloid-Derived Suppressor Cells Orchestrate Immunosuppressive Networks in Idiopathic Pulmonary Fibrosis/ I.E. Fernandez, F.R. Greiffo, V. Viteri-Alvarez, I. Bastidas, R. Roy, M. Frankenberger, J. Behr, A. Forrest, A. Hilgendorff, O. Eickelberg, Munich, Germany, p.A1231 708 Enhanced Anti-Fibrotic Efficacy of Thy-1-Sorted Mesenchymal Stem Cell-Derived Extracellular Vesicles/ C. Tan, S.S. Wong, C. Espinoza, X. Li, J.S. Hagood, Beijing, China, p.A1232 709 PAI-1-Stimulated AT2 Cell SASP Promotes Profibrotic Polarization of Alveolar Macrophages/ T. Rana, C. Jiang, G. Liu, V.B. Antony, V.J. Thannickal, R.M. Liu, Birmigham, AL, p.A1233 710 IL-11 Is a Therapeutic Target in Idiopathic Pulmonary Fibrosis/ B. Ng, J. Dong, S. Viswanathan, G.A. D’Agostino, A.A. Widjaja, W.-W. Lim, N. Ko, J. Tan, S.P. Chothani, A.-M. Chacko, N. Guimaraes-Camboa, S.M. Evans, A.J. Byrne, T.M. Maher, J. Liang, P.W. Noble, S. Schafer, S.A. Cook, Singapore, Singapore, p.A1234 711 Receptor Type Protein Tyrosine Phosphatase ? (PTPRJ/CD148) Deficiency in Fibroblasts Leads to Increased Fibrosis by Regulating PI3K/Akt/mTOR Signaling, Autophagy and P62 Level/ K. Tsoyi, S. Chu, K. Xiong, B. Ith, A. Esposito, S. Poli, E. Ayaub, X. Liu, S. El-Chemaly, M. Perrella, I. Rosas, Boston, MA, p.A1235 712 Microvesicle Expression of Growth Hormone Receptor from Mesenchymal Cells Supports the Lung Epithelial Stem Cell Niche and Abrogates Pulmonary Fibrosis in Mice/ T. Xie, V. Kulur, N. liu, C. Liang, D. Jiang, P. Chen, P. Noble, Los Angeles, CA, p.A1236 713 Circulating Plasma Proteins Differentially Detected in Idiopathic Pulmonary Fibrosis and in Subjects with Pre-Clinical Pulmonary Fibrosis/ S.K. Mathai, F. Metzger, J. Cardwell, J. Kropski, J. Powers, A.D. Walts, C. Markin, K.K. Brown, M.P. Steele, M.I. Schwarz, D.A. Lynch, O. Eickelberg, T.E. Fingerlin, J.E. Loyd, S.M. Hauck, I.V. Yang, D.A. Schwartz, Dallas, TX, p.A1237 714 Urine Proteomics Identifies Novel Biomarkers of IPF Disease Progression and Resolution/ M. Decaris, M. Rexhepaj, J. Vowinckel, N. Dupuis, Y. Wei, L.P. Hariri, J.R. Greenland, H.A. Chapman, J.S. Lee, P.J. Wolters, S. Turner, South San Francisco, CA, p.A1238 715 Peptidylarginine Deiminase 4 Contributes to the Profibrotic Phenotype of Fibroblasts from Patients with Idiopathic Pulmonary Fibrosis and Promotes Experimental Pulmonary Fibrosis/ A.J. Esposito, S. Chu, S. Poli De Frias, B. Sun, T.J. Doyle, S.Y. El-Chemaly, M.A. Perrella, I.-C. Ho, K. Tsoyi, I.O. Rosas, Boston, MA, p.A1239 716 Regulator of Cell Cycle (RGCC) Protects from Pulmonary Fibrosis/ S.P. Atamas, V. Rus, H. Rus, V. Lockatell, N.W. Todd, I.G. Luzina, Baltimore, MD, p.A1240 717 Alveolar Epithelial Fgfr2 Signaling Is Required for Recovery from Bleomycin-Induced Injury/ R. Guzy, S. Dorry, A. Meliton, D. Ornitz, G.M. Mutlu, Chicago, IL, p.A1241 718 Role of Regulator of Telomere Elongation Helicase 1 (RTEL1) in Experimental Models of Pulmonary Fibrosis/ N. Winters, C. Calvi, C. Habermann, H. Ding, T.S. Blackwell, J. Kropski, Nashville, TN, p.A1242 719 CD 36 Promotes Lung Fibrosis in Response to Oxidized Phospholipids: Role of Lung Macrophages?/ P. Bradley, V. LaLone, N. Subbotina, M. Dotson, S. Teitz-Tennenbaum, J.J. Osterholzer, T.H. Sisson, Ann Arbor, MI, p.A1243 720 Reducing Protein Cysteine Oxidation by Coordinate Action of Oxidoreductases Reverses Existing Increases in Lung Fibrosis/ Y.M.W. Janssen-Heininger, E. Elko, A. Kumar, A. Van Der Vliet, V. Anathy, Burlington, VT, p.A1244 721 Defective Fatty Acid Metabolism Promotes Fibrosis in the Lung/ D.M. Alvarez, M. Bueno, L. Tu, B. Kimball, G. Eric, M. Rojas, A.L. Mora, Pittsburgh, PA, p.A1245 722 Expression of a Prototypical Surfactant Protein C BRICHOS Mutation Causes Epithelial ER Stress, Spontaneous Lung Injury and Fibrotic Remodeling/ M.A.H. Barrett, J. Katzen, A. Venosa, S.J. Russo, M.F. Beers, Philadelphia, PA, p.A1246 723 Omipalasib Modulates Extracellular Matrix Turnover in IPF Patients: Exploratory Biomarker Analysis from a Phase I Proof of Mechanism Study/ C.B. Nanthakumar, J. Eley, Y. Man, N.S. Gudmann, R.C. Chambers, A. Blanchard, W. Fahy, T.M. Maher, Hertfordshire, United Kingdom, p.A7301 724 Metabolic Mechanisms of Alveolar Progenitor Aging in Lung Fibrosis in Mice and Men/ D. Jiang, C.J. Liang, F. Taghvifar, N. Liu, N. Deng, W. Yizhou, G. Huang, X. Liu, P.W. Noble, Los Angeles, CA, p.A7302 725 Syndecan-1 Promotes Lung Fibrosis by Altering MicroRNA Cargo Within Extracellular Vesicles/ T. Parimon, C. Yao, L. Ge, R. Brauer, D.M. Habiel, S. Bora, T. Xie, D. Jiang, M. Koenigshoff, N. Deng, T. Antes, C.M. Hogaboam, P.W. Noble, B.R. Stripp, P. Chen, Los Angeles, CA, p.A7303 ATS 2019 • Dallas, TX SUNDAY • MAY 19 43 SUNDAY MORNING