ATS 2019 Virtual Final Program

605 Circulating Mitochondrial DNA Is Associated with Fibroblast Activation and Disease Progression in Scleroderma Associated Interstitial Lung Disease/ C. Ryu, H. Sun, J. Winkler, S. Meena, A. Walia, M. Minasyan, C. Brandsdorfer, M. Gulati, X. Peng, E. Herzog, New Haven, CT, p.A7219 606 The Sphingosine Kinase 1 Inhibitor, PF543, Mitigates Asbestos-Induced Pulmonary Fibrosis and Lung mtDNA Damage in Mice/ S.-J. Kim, P. Cheresh, L.S. Huang, S. Watanabe, N. Joshi, K. Williams, R. Piseaux-Allion, M. Chi, A. Yeldandi, A. Lam, A. Misharin, G.S. Budinger, V. Natarajan, D.W. Kamp, Chicago, IL, p.A7220 607 Epigenetic Regulation of the Klotho/miz1 Axis Promotes Cigarette-Smoke Extract (CSE)-Induced Alveolar Epithelial Cell (AEC) mtDNA Damage and Apoptosis/ S.-J. Kim, P. Cheresh, L. Jing, B.D. Singer, R. Kalhan, K.M. Ridge, A. Lam, D.W. Kamp, Chicago, IL, p.A7221 608 Profibrotic Effects of Mir-33 - Role of Autophagy and Mitochondrial Homeostasis in Macrophages, and Therapeutic Implications/ F. Ahangari, N.L. Price, J.C. Schupp, K.-A.S. Rose, G.H. Ibarra, G. DeIuliis, N. Xylourgidis, A. Prasse, C. Fernandez-Hernando, N. Kaminski, New Haven, CT, p.A7222 609 MCU Modulates Transcriptional Network for PGC-1a-Mediated Fatty Acid Oxidation During Pulmonary Fibrosis/ L. Gu, J.L. Casey, D. Davis, A.B. Carter, Birmingham, AL, p.A7223 610 The Role of TRPA1/TRPV1 in PM2.5 -Induced Airway Epithelial Cell Injury Model/ F. Li, M. Wang, Shanghai, China, p.A7224 611 Susceptibility of Microtuble-Associated Protein 1 Light Chain 3 Beta Knockout Mice to Lung Injury and Fibrosis/ V.S. Kesireddy, S. Ahuja, S. Chillappagari, L. Knudsen, I. Henneke, J. Graumann, S. Meiners, M. Ochs, C. Ruppert, M. Korfei, W. Seeger, A. Guenther, P. Mahavadi, Giessen, Germany, p.A7225 612 Stimulation of the Na+/K+-ATPase Leads to a Differential Response in Bone Marrow-Derived Macrophages/ L.M. Kimmig, P.S. Woods, K.A. Sun, E.M. O’Leary, A.Y. Meliton, Y. Tian, R.B. Hamanaka, G.M. Mutlu, Chicago, IL, p.A7226 613 Nadph Oxidase 4 (NOX4) Controls Translational Homeostasis and Mitochondrial Biogenesis Via 4E-BP1/ K. Bernard, N.J. Logsdon, V.J. Thannickal, Birmingham, AL, p.A7227 614 Mitochondrial Dysfunction, Mitostress and Mitochondria Transfer In Cigarette Smoke-induced Lung Epithelial Senescence/ I. Rahman, K. Maremanda, I.K. Sundar, Rochester, NY, p.A7228 615 The Role of Mitochondrial P66shc and Cyclophilin D in Biological Aging of the Lung/ C.F. Garcia Castro, N. Sommer, M. Korfei, M. Bednorz, B. Kojonazarov, S. Kraut, N. Alebrahimdehkordi, S. Arnhold, R. Schulz, N. Weissmann, O. Pak, Giessen, Germany, p.A7229 616 Role of PINK1 Mediated Mitophagy During Streptococcus Pneumoniae Pneumonia/ Y. Zhang, L.K. Sharma, A.J. Losier, E. Ifedigbo, M. Sauler, I.S. Bazan, C. Dela Cruz, P. Lee, New Haven, CT, p.A7230 617 PBI-4050 Attenuates Bleomycin-Induced Lung Fibrosis by Reducing Fibrosis, Inflammation, and ER Stress/ M. Leduc, M. Tremblay, B. Grouix, A. Perreault, F. Sarra-Bournet, A. Laverdure, L. Gervais, A. Felton, P. Laurin, L. Gagnon, Laval, Canada, p.A7231 618 Assessing the Role of ATF6 a in the Alternative Activation of Macrophages in the Progression of Fibrotic Lung Diseases/ O. Mekhael, H. Patel, J. Imani, E. Ayaub, M. Padwal, A. Ayoub, M. Vierhout, M. El-Taweel, S. Naiel, A. Rullo, J.A. Hirota, N. Hambly, D. Bridgewater, A. Naqvi, M.R.J. Kolb, K. Ask, Hamilton, Canada, p.A7232 619 Transcriptomic Analysis Identifies Pathways Mediating Alveolar Epithelial Type II (AT2) Cell Dysfunction and Fibrosis in Response to ER Stress Following Grp78 Knockout (KO)/ B. Zhou, M. Horie, P. Flodby, H. Wang, Y. Liu, A. Lee, Z. Borok, Los Angeles, CA, p.A7233 620 A Bronchial Airway Gene Expression Signature of Future Lung Function Decline Is Enriched in XBP1-Regulated Genes/ E.J. Becker, A. Faiz, M. Van Den Berge, W. Timens, P.S. Hiemstra, G. Liu, X. Zhang, Y.O. Alekseyev, G.T. O’Connor, S. Lam, A. Spira, M.E. Lenburg, K. Steiling, Boston, MA, p.A7234 621 Muc5b-Overexpression Promotes Increased ER Stress in Mouse Models of Pulmonary Fibrosis/ J.E. Michalski, A.M. Estrella, C.E. Hennessy, I.T. Stancil, E. Dobrinskikh, I.V. Yang, D.A. Schwartz, Aurora, CO, p.A7235 622 AP-3-Dependent Mechanisms Regulate the Trafficking of ATP8a1 to Lamellar Bodies in Alveolar Type 2 Cells/ S. Kook, P. Wang, S. Meng, L. Goetzl, M.S. Marks, S.H. Guttentag, Nashville, TN, p.A7236 623 Immuno-Metabolic Alterations in Systemic Immune Cells of Tobacco-Smoke Associated Chronic Obstructive Pulmonary Disease (COPD) Subjects/ A. Agarwal, S. Kadam, A. Brahme, M. Agrawal, K. Apte, G. Narke, B. Ghosh, S. Madas, S.S. Salvi, Pune, India, p.A7237 624 Increased Susceptibility to Gammaherpesvirus-Induced Lung Fibrosis of Transgenic Mice with Conditional Overexpression of the Pro-Apoptotic ER-Stress-Factor Chop in Alveolar Epithelium/ M. Korfei, M. Smaida, O. Klymenko, C. Ruppert, I. Henneke, I. Shalashova, M. Huehn, P. Mahavadi, S. Herold, W. Seeger, H. Adler, A. Guenther, Giessen, Germany, p.A7480 BASIC • CLINICAL • TRANSLATIONAL POSTER DISCUSSION SESSION D108 MECHANISM OF LUNG INJURY 1:30 p.m. - 3:30 p.m. KBHCCD Ballroom D Four (Level 3) Poster Viewing 1:30-2:15 Discussion 2:15-3:30 Chairing: B.J. Smith, PhD, Aurora, CO T. Winkler, PhD, Boston, MA 701 Cell Injury Cluster Progression During Ventilator-Induced Injury/ C. Mattson, K. Okamura, M. Kiselevach, B.J. Smith, Aurora, CO, p.A7238 ATS 2019 • Dallas, TX 388 WEDNESDAY • MAY 22