ATS 2019 Virtual Final Program

305 Role of Long Non-Coding RNA H19 in Coronary Artery Remodeling in PAH Patients with Right Ventricular Failure/ V. Nadeau, J. Omura, S. Martineau, K. Habbout, S. Breuils-Bonnet, F. Potus, S.L. Archer, R. Paulin, S. Provencher, O. Boucherat, S. Bonnet, Quebec City, Canada, p.A7197 306 A Microrna96 Mimic Delivered Direct to the Lungs Can Reverse Sugen/Hypoxia-Induced Pulmonary Hypertension in the Rat/ C.K. Docherty, S. Fisher, M. Nilsen, M.R. MacLean, Glasgow, United Kingdom, p.A7198 307 Overexpression of miR125b Induces Group3 Pulmonary Hypertension in Pre-Existing Pulmonary Fibrosis/ S. Umar, M. Vaillancourt, G. Ruffenach, J. Hong, N. Cao, T. Le, C. Makar, M. Mikhael, L. Saddic, F. Sy, D. Younessi, M. Li, M. Eghbali, Los Angeles, CA, p.A7199 308 HIV Infected- Cocaine Treated Macrophage-Derived Extracellular Vesicles Augment Vascular Remodeling in HIV-Tg Rats/ S. Agarwal, M. Chinnappan, H. Sharma, A. Mohan, J. Allen, L. Chen, M. Wulser, C. Lawrence, N.K. Dhillon, Kansas City, KS, p.A7200 309 microRNA-483 Ameliorates Pulmonary Arterial Hypertension/ J. Zhang, X. Wang, J. Zhang, Z. Jing, J. Shyy, Xi’an, China, p.A7201 310 Biomarker Diagnostics for Pulmonary Hypertension: Studies in Management by Exercise Training or Nightly Oxygen/ G. Grunig, C.A. Eichstaedt, S. Ulrich, N. Durmus, S. Saxer, E. Gruenig, S. Pylawka, New York, NY, p.A7202 311 FTY720 S-Phosphonate Significantly Inhibits MRSA Induced Permeability, Inflammation and Epigenetic Changes in Lung Endothelium/ L. Wang, S.M. Dudek, Chicago, IL, p.A7203 312 Histone Deacetylases 1 and 2 Play Essential Roles in the Lipopolysaccharide (LPS) Dependent Disruption of the Endothelial Barrier via the Repression of the Transcription Factor Sox18/ E. Zemskov, C.M. Gross, S. Aggarwal, W. Ornatowski, A. Kangath, Q. Lu, S.M. Black, Tucson, AZ, p.A7204 313 Examining the Impact of Endothelial Bone Morphogenic Protein Receptor 2 Loss on Interleukin-15 Signaling and the Pathogenesis of Pulmonary Arterial Hypertension/ L.R. Hilton, M. Ratsep, P. Lima, M. Mitchell, M.L. Ormiston, Kingston, Canada, p.A7205 314 Loss of KCNK3 in Mice Drives Susceptibility to Inflammatory Pulmonary Arterial Hypertension/ A. Rathinasabapathy, E.D. Austin, H. Tanjore, T. Sherrill, T. Blackwell, G. Muthian, C. Moore, S. Gladson, S. Shay, S.M. Majka, J.D. West, Nashville, TN, p.A7206 315 Transcription Factor TBX4 Regulates Genes and Pathways Involved in Pulmonary Arterial Hypertension/ L. Yan, M.J. Kielt, Y. Cai, L. Hedges, B.L. Nunley, J. Sucre, E.D. Austin, R. Hamid, Nashville, TN, p.A7207 316 A Role for Rho-Associated Kinase in Aberrant Pulmonary Vascular Reactivity in a Mouse Model of Cerebral Autosomal Dominant Subcortical Infarcts and Leukoencephalopathy (CADASIL)/ H. Morris, K.B. Neves, A.C. Montezano, M.R. MacLean, R.M. Touyz, Glasgow, United Kingdom, p.A7208 317 Myosin Light Chain Kinase Genetic Variation and the Risk of Precapillary Pulmonary Hypertension in Sickle Cell Disease/ D. Fraidenburg, K. Batai, T. Abbasi, J.G.N. Garcia, M.T. Gladwin, V.R. Gordeuk, R. Kittles, R.F. Machado, Chicago, IL, p.A7209 318 Opposite Effects of Guanosine in Inflammatory Versus Angioproliferative Experimental Pulmonary Hypertension/ S.P. Tofovic, J. Hu, F. Schneider, E. Jackson, Pittsburgh, PA, p.A7210 319 Smooth Muscle Cell Loss of the Tumor Suppressor WWOX Contributes to the Development of Pulmonary Hypertension/ M. Teixeira Gomes, J. Chen, S. Haider, Y. Bai, S. Singla, R.F. Machado, Indianapolis, IN, p.A7211 320 Survivin Inhibition as a Potential Target for Pulmonary Arterial Hypertension/ I. Blanco, M. Marquina, O. Tura-Ceide, V.I. Peinado, J.A. Barbera, Barcelona, Spain, p.A7212 321 Non-Muscle Myosin Light Chain Kinase Activity Mediates Endothelial Cell Proliferation and Inhibits Apoptosis in Pulmonary Arterial Hypertension/ M. Anis, J.R. Jacobson, D.R. Fraidenburg, Chicago, IL, p.A7213 322 The Transcription Factor TBX4 Regulates the Expression of CYP1B1/ M. Kielt, L. Yang, Y. Cai, L. Hedges, J. Sucre, R. Hamid, E.D. Austin, Nashville, TN, p.A7214 BASIC • TRANSLATIONAL POSTER DISCUSSION SESSION D107 MITOCHONDRIA AND ER STRESS IN HOMEOSTASIS AND REPAIR 1:30 p.m. - 3:30 p.m. KBHCCD Ballroom D Three (Level 3) Poster Viewing 1:30-2:15 Discussion 2:15-3:30 Chairing: P. Lee, MD, New Haven, CT K. Suresh, MD, Baltimore, MD A. Sarkar, PhD, Columbus, OH 601 Mitochondrial Uncoupling Protein-2 Is a Putative Link Between Mitochondrial Dysfunction and Fibroblast Senescence in Age-Related Lung Fibrosis/ S. Rangarajan, M.L. Locy, V. Darley-Usmar, J.W. Zmijewski, R.M. Tuder, O. Eickelberg, V.J. Thannickal, Aurora, CO, p.A7215 602 Mitochondrial Malate Dehydrogenase (MDH2) Regulates Macrophage Alternative Activation During Pulmonary Fibrosis Development/ C. He, J.L. Casey, L. Gu, A.B. Carter, Birmingham, AL, p.A7216 603 Mechanisms of Mitochondrial Transfer in Health and Disease/ J. Frankenberg Garcia, C. Michaeloudes, B. Xu, K.F. Chung, S.E. Harding, T.A. Rodriguez, P.K. Bhavsar, London, United Kingdom, p.A7217 604 Mechanical Stretch Causes Mitochondrial Dysfunction and the Release of Mitochondrial DAMPs in Alveolar Epithelial Cells/ S. Grazioli, I. Dunn-Siegrist, J. Pugin, Geneva, Switzerland, p.A7218 ATS 2019 • Dallas, TX WEDNESDAY • MAY 22 387 WEDNESDAY AFTERNOON