ATS 2019 Virtual Final Program

614 Differential DNA Methylation and Aging Patterns According to Regional COPD Severity in Lung Tissue/ F. Xu, D.M. Vasilescu, C.X. Yang, J. MacIsaac, D. Lin, M.S. Kobor, T.-L. Hackett, M. Obeidat, D.D. Sin, J.C. Hogg, J. Leung, Vancouver, Canada, p.A5775 615 Small Airway Fibrosis in COPD Is Mediated by Histone Acetylation/ R. Zakarya, H. Chen, C.-A.A. Brandsma, I.M. Adcock, B.G.G. Oliver, Sydney, Australia, p.A5776 616 Reduced MaximumMid-Expiratory Flow Is Independently Associated with Computed Tomography Measures of Smoking-Related Lung Disease in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS) Cohort/ B. Ronish, M. Quibrera, I. Barjaktarevic, C.B. Cooper, R.E. Kanner, C.S. Pirozzi, V. Kim, J.M. Wells, M.K. Han, P. Woodruff, V.E. Ortega, S.P. Peters, E.A. Hoffman, R.G. Buhr, B.A. Dolezal, T.G. Liou, L. Bateman, J.D. Schroeder, D. Couper, R. Paine, Salt Lake City, UT , p.A5777 617 Decrypting Orthopnea in Chronic Obstructive Pulmonary Disease (COPD) Using the Forced Oscillation Technique/ E. Marchand, M. Zambrano-Braun, Yvoir, Belgium, p.A5778 618 Where the Sparks Begin: Small Airway Dysfunction in Patients with Preserved Pulmonary Function/ Y.H. Hsiao, H.-Y. Chiu, D.-W. Perng, Taipei, Taiwan, p.A5779 619 Changes in Lung Volumes Across GOLD Stages of COPD: Implications for Mechanisms of Air Trapping/ S. Zeng, A. Zhang, S. Vasudevan, M. Nishihama, B. Giang, M. Dunn, M. Bhogale, M. Arjomandi, San Francisco, CA, p.A5780 620 Extracellular Matrix Subtypes Are Altered Within the Airway Smooth Muscle Layer in Chronic Obstructive Pulmonary Disease/ A.L. James, A. Cairncross, F. Sanai, B.E. McParland, G.G. King, P.B. Noble, J.G. Elliot, Nedlands, Australia, p.A5781 621 COPD-Specific Chondroitin Sulfate Modifications Are Linked to TGF-B1/ O. Hallgren, H.N. Alsafadi, A. Nybom, X.-H. Zhou, L.H. Bjermer, G. Westergren Thorsson, Lund, Sweden, p.A5782 622 Spirometry End of Test Volume (EOTV) ATS/ERS Standards in COPD: Lessons from the Pulmonary Trials Cooperative Spirometry Quality Assurance Program/ R.C. Wilson, R.A. Wise, D.A. Kaminsky, C.G. Irvin, K. Anstrom, D.H. Au, M.K. Han, J.T. Holbrook, J. Ma, F.J. Martinez, P. Woodruff, M. Brooks, S.R. Wisniewski, F.C. Sciurba, Pittsburgh, PA, p.A5783 623 The Histopathological Basis of Airflow Limitation in Small Airways Disease/ S. Gutor, R.-H. Du, R.F. Miller, B.W. Richmond, P.P. Massion, T.S. Blackwell, V.V. Polosukhin, Nashville, TN, p.A5784 624 Role and Mechanism Research of NOX4 and ESRP1 in Airway Epithelial-Mesenchymal Transition/ C. Jieda, B. Hao, X. Guo, Q. Cai, Y. Li, J. Chen, Yinchuan, China, p.A5785 BASIC • CLINICAL • TRANSLATIONAL POSTER DISCUSSION SESSION C109 RESPIRATORY MUSCLE DYSFUNCTION: MECHANISM AND ASSESSMENT 2:15 p.m. - 4:15 p.m. KBHCCD Ballroom D Four (Level 3) Poster Viewing 2:15-3:00 Discussion 3:00-4:15 Chairing: B.J. Petrof, MD, Montreal, Canada B. Jung, MD, PhD, Montreal, Canada G.C. Sieck, PhD, Rochester, MN 701 Mechanical Contraction, Nutritional Supplementation and Muscle Reoxygenation to Counteract Skeletal Muscle Cell Atrophy Induced by Hypoxia/ S. Bensaid, C. Fabre, P. Mucci, C. Cieniewski-Bernard, Loos, France, p.A5786 702 Effect of Peritoneal Dialysis on the Dynamic Functions of the Diaphragm/ K. Supraja, G. Abraham, A. Jayanthi, Chennai, India, p.A5787 703 The Fatigue Index Test (FIT): Clinical Manifestations of a Novel Measure of Inspiratory Muscle Fatigue in COPD/ M.F. Formiga, I.A. Vital, G. Urdaneta, M.A. Campos, L.P. Cahalin, Coral Gables, FL, p.A5788 704 Diaphragmatic Dysfunction Following Thoracic Surgery: An Echographic Assessment/ M. Daniel, T.M. Huynh, J. Martin, A. Ferraris, K. Guessous, D. Zlotnik, L. Gouzien, O. Chaouch, P. Delval, K.J. Boucebci, C. Pricopi, F. Le Pimpec-Barthes, B. Cholley, Paris, France, p.A5789 705 Diaphragm Thickening Fraction and Its Relation with Disease Severity and Symptoms in Patients with Chronic Obstructive Pulmonary Disease: Comparison of Measurements Performed During Tidal Breathing and Maximal Inspiration/ A.-C. Maynard-Paquette, C. Poirier, B.-P. Dubé, Montréal, Canada, p.A5790 706 Restrictive Disease Pattern on Pulmonary Function Testing in Obesity: Can It Be Explained by Diaphragmatic or Neuromuscular Weakness?/ A. Mangardich, O. Al Qarni, E.A. Becker, S.H. Mirza, Chicago, IL, p.A5791 707 Relationship Between Diaphragmatic Excursion and Maximum Inspiratory Pressure (MIP) in Adults Patients with Guillain Barré Syndrome/ F.J. Ríos, B.V. Rivero, Santiago, Chile, p.A5792 708 Don’t Take It for Granted! Improving Accurate Height Measurements for Pulmonary Function Testing in Non-Ambulatory Patients/ S. Naime, M.A. Arroyo Morr, G.R. Nino, G.F. Perez, Washington, DC, p.A5793 709 Ultrasound Assessment of Diaphragmatic Thickening in Patients with ALS/ S.A. Waheed, C. Cunningham, S. Gogineni, G. Pellegrino, G.F. Sferrazza Papa, D.E. Kvarnberg, F. Di Marco, M.J. Tobin, F. Laghi, Hines, IL, p.A5794 ATS 2019 • Dallas, TX 308 TUESDAY • MAY 21