ATS 2019 Virtual Final Program

511 RIG-I Signaling Via MAVS Is Dispensable for Survival in Lethal Influenza Infection In Vivo/ J.P. Metcalf, W. Wu, W. Zhang, L. Tian, J.L. Booth, M. Dozmorov, Oklahoma City, OK, p.A5752 512 FOXO3A Regulates Antiviral Responses in Airway Epithelium/ S. Kotnala, J.A. Gimenes, H. Reddy Vari, N. Owuor, N. Xander, W. Li, U. Sajjan, Philadelphia, PA, p.A5753 513 Mesenchymal Stem Cell Plasticity and Therapeutic Programming in Acute Lung Injury/ M.M. Barroso, A.I. Vazquez, L. Jankauskaite, T. Braun, S. Herold, Giessen, Germany, p.A5754 514 Modulation of Rhinovirus-Induced Responses in Airway Epithelial Cells by Cigarette Smoke: Effect of Short-Time Smoking Cessation/ P.S. Hiemstra, Y. Wang, P.P. Romeo, J. Nikkels, D.K. Ninaber, J.A. Schrumpf, A.M. van der Does, Leiden, Netherlands, p.A5755 515 Growth Differentiation Factor 15 (GDF15)-Mediated Lung Aging Promotes Human Rhinovirus Infection and Virus-Induced Inflammation/ Q. Wu, W. Ren, S. Ye, M. Koenigshoff, O. Eickelberg, Aurora, CO, p.A5756 516 Pulmonary Surfactant Lipids Antagonize Human Rhinovirus Infections/ M. Numata-Nakamura, H. Lee, H.W. Chu, M.A. Seibold, D.R. Voelker, Denver, CO, p.A5757 517 Disruption of the Airway Epithelial Barrier in a Murine Model of RSV infection/ C.C. Smallcombe, D. Linfield, T.J. Harford, V. Bokun, A.I. Ivanov, G. Piedimonte, F. Rezaee, Cleveland, OH, p.A5758 518 Targeting Immunophilin- and MAPK-Associated Pathways to Inhibit MERS-CoV Replication and Prevent Lung Injury/ C. Peteranderl, L. Sauerhering, L. Meier, B. Nganko, A. Kupke, B. Selvakumar, S. Becker, S. Herold, Giessen, Germany, p.A5759 519 Mapping IFITM3 in the Lung at Homeostasis and During Viral Assault/ E.K. Allen, D.F. Boyd, L.-A. Van de Velde, J.C. Crawford, P.G. Thomas, Memphis, TN, p.A5760 520 Deep Learning in Computer Vision Provides Valuable Insights and Improved Efficiency for Lung Cytology and Histopathology/ R. Xiao, M.P. Goldklang, K.N. Stearns, J.M. D’Armiento, New York, NY, p.A5761 BASIC • CLINICAL • TRANSLATIONAL POSTER DISCUSSION SESSION C108 COPD: PHENOTYPE, MECHANISM, AND TREATMENT 2:15 p.m. - 4:15 p.m. KBHCCD Ballroom D Three (Level 3) Poster Viewing 2:15-3:00 Discussion 3:00-4:15 Chairing: J.K. Burgess, PhD, Groningen, Netherlands A.L. James, MD, MBBS, PhD, Nedlands, Australia J. Leung, MD, Vancouver, Canada 601 A Machine Learning Approach to Identify Clinical Phenotypes Within Non-Distinct Obstructive Airway Diseases/ N. Das, S. Everaerts, M. Topalovic, N. Lorent, P. Van Bleyenbergh, L.J. Dupont, J.-M. Aerts, W. Janssens, Leuven, Belgium, p.A5762 602 Can Machine Learning and MRI Identify COPD Patients at Risk of Accelerated Progression?/ C. Ong Ly, A. Westcott, I. Dhaliwal, A. Fenster, M. Kirby, G. Parraga, London, Canada, p.A5763 603 The Value of Maximal Expiratory Flow-Volume Curve in Estimating the Presence and Severity of Emphysema as Assessed on CT/ M. Occhipinti, M. Paoletti, E.A. Regan, D.A. Lynch, J.D. Crapo, S. Colagrande, E.K. Silverman, M. Pistolesi, Firenze, Italy, p.A5764 604 Association Between CT-Derived Emphysema and MRI-Derived Fractional Ventilation in Advanced COPD Subjects/ R. Baron, H. Hamedani, F. Amzajerdian, S. Kadlecek, I. Duncan, Y. Xin, S. Siddiqui, M. Cereda, R. Rizi, Philadellphia, PA, p.A5765 605 Mucus Plugs on CT and Lung Function, Respiratory Symptoms, and Quality of Life in COPD/ Y. Okajima, C.E. Come, P. Nardelli, S.K. Sonavane, H.P. Nath, N. Terry, S.A. Grumley, D.A. Lynch, B.J. Make, E.K. Silverman, G.R. Washko, R. San José Estépar, A. Diaz, Boston, MA, p.A5766 606 Associations Between Lung Function Trajectories and Quantitative Computed Tomography Measures of Pectoralis Measures/ J. Ross, A. Diaz, G. Vegas-Sanchez-Ferrero, G.R. Washko, R. San Jose Estepar, Boston, MA, p.A5767 607 Associations Between Lung Function Trajectories and Emphysema Type/ J. Ross, A. Diaz, G. Vegas-Sanchez-Ferrero, D.A. Lynch, G.R. Washko, R. San Jose Estepar, Boston, MA, p.A5768 608 CT Airway Count as a Biomarker of Asthma Pathogenesis: Severe Asthma and ACOS in Never-Smokers/ R. Eddy, D.G. McCormack, M. Kirby, G. Parraga, London, Canada, p.A5769 609 Normal Thoracic CT in Ex-Smokers Without COPD: Can Machine Learning Reveal Subclinical Disease?/ A.R. Westcott, M. Kirby, D.G. McCormack, G. Parraga, London, Canada, p.A5770 610 A Multibreath Wash-in 129Xe MR Imaging Scheme to Measure Regional Fractional Ventilation in Human Subjects/ H. Hamedani, R. Baron, S. Kadlecek, K. Ruppert, F. Bermudez, S. Siddiqui, Y. Xin, M. Pourfathi, F. Amzajerdian, L. Loza, T. Achekzai, I. Duncan, M. Cereda, F. Sertic, R.R. Rizi, Philadelphia, PA, p.A5771 611 A Comparison of Hyperpolarized Gas Imaging of Aeration and Fractional Ventilation/ H. Hamedani, F. Bermudez, R. Baron, S. Kadlecek, K. Ruppert, Y. Xin, S. Siddiqui, M. Pourfathi, F. Amzajerdian, L. Loza, T. Achekzai, I. Duncan, M. Cereda, F. Sertic, R.R. Rizi, Philadelphia, PA, p.A5772 612 Bronchiectasis, Vascular Pruning and Ventilation Defects in COPD and Bronchiectatic Patients: Are They Related?/ A.L. Barker, R.L. Eddy, A.M. Matheson, A.R. Westcott, G.R. Washko, G. Parraga, London, Canada, p.A5773 613 Effect of Family with Sequence Similarity 13 Member A( FAM13A) on the Risk of Chronic Obstructive Pulmonary Disease and Its Role in Small Airway Disease/ J. Zhu, Yinchuan, China, p.A5774 ATS 2019 • Dallas, TX TUESDAY • MAY 21 307 TUESDAY AFTERNOON