ATS 2019 Virtual Final Program

P936 Extracellular Matrix (ECM) Proteins in Airway and in COPD Mice: Regional Expression Difference and Potential Mechanism Mediated by Transforming Growth Factor-ß1 (TGF-ß1)/ Y. Zeng, W. Hu, Y. Zuo, J. Zhang, Shanghai, China, p.A7437 BASIC • TRANSLATIONAL THEMATIC POSTER SESSION C64 PULMONARY FIBROSIS MODELS AND MECHANISTIC INSIGHTS 9:15 a.m. - 4:15 p.m. KBHCCD Area C (Hall F, Level 2) Viewing: Posters will be on display for entire session. Discussion: 11:15-12:00: authors will be present for individual discussion 12:00-1:00: authors will be present for discussion with assigned facilitators. Facilitator : C.M. Hogaboam, PhD, Los Angeles, CA P399 Collagen Prolyl 4-Hydroxylase as a Therapeutic Target in Idiopathic Pulmonary Fibrosis/ B. Gary, A.R. Savage, B. Summers, R.B. Silver, New York, NY, p.A5390 P400 A Novel siRNA-Based Oligonucleotide, TRK-250, and Its Efficacy for Treatment of Idiopathic Pulmonary Fibrosis (IPF)/ A. Shibata, T. Matsumoto, M. Uchida, M. Yamada, Y. Miyamoto, H. Inada, Y. Eguchi, W. Toriumi, Kurume, Japan, p.A5391 P401 Caveolin-1-Scaffolding Peptide Attenuates Pulmonary Fibrosis/ V. Radhakrishnan, L. Fan, A.S. Marudamuthu, V. Gopu, N. Tiwari, S.K. Shetty, M. Nagaraja, N. Marchetti, S. Bolla, R.O. Williams, III, G.J. Criner, S. Idell, S. Shetty, Tyler, TX, p.A5392 P402 Interleukin-9 Blockade Suppresses Silica-Induced Lung Inflammation and Fibrosis in Mice/ N. Sugimoto, M. Suzukawa, H. Nagase, Y. Koizumi, S. Miyoshi, K. Kobayashi, H. Yoshihara, Y. Kojima, A. Kamiyama, A. Hebisawa, K. Ohta, Tokyo, Japan, p.A5393 P403 Single Cell Transcriptome Sequencing Identifies Pathogenic IPF Mesenchymal Progenitor Cells/ D. Beisang, K. Smith, A. Gilbertsen, A. Bunyemov, J. Herrera, C.A. Henke, P.B. Bitterman, Minneapolis, MN, p.A5394 P404 Inhalation Toxicity of a Novel siRNA-Based Oligonucleotide, TRK-250 in Cynomolgus Monkeys/ W. Toriumi, M. Uchida, A. Maeda, C. Sakai, T. Yamada, T. Hamasaki, H. Inada, Y. Miyamoto, Kurume, Japan, p.A5395 P405 Comprehensive Metabolome Analysis Reveals New Mechanism of Anti-Fibrotic Factor Stanniocalcin-1 (STC1) Which Modulate Epigenetic Regulation and Oxidative Stress/ S. Ohkouchi, M. Kanehira, D. Saigusa, T. Tamai, M. Tabata, T. Irokawa, H. Ogawa, Y. Okada, H. Kurosawa, Sendai, Japan, p.A5396 Facilitator : M.N. Ballinger, PhD, Columbus, OH P406 CCL2/12 from Injured Alveolar Epithelial Cells Initiated and Promoted Progressive Pulmonary Fibrosis/ J. Yang, M. Agarwal, K.K. Kim, Ann Arbor, MI, p.A5397 P407 Efficacy of MePEG PCL Diblock Copolymeric Nanoparticles and PCL Nanoparticles for Drug Delivery in Lung Fibrosis/ A. Singh, R. Kulshrestha, A. Pandey, M. Kaushik, A.K. Dinda, New Delhi, India, p.A5398 P408 Time-Resolved Proteome and Transcriptome Landscape of Paraquat-Induced Pulmonary Fibrosis/ L. Fan, H. Sun, Y. Wu, F. Zhang, J. Zhang, Nanjing, China, p.A5399 P409 Deletion of Alveolar Epithelial Type II Sine Oculis Homeobox Homolog 1 (Six1) Attenuates Established Pulmonary Fibrosis/ C. Wilson, T. Mertens, S. Collum, W. Bi, A. Guha, R. Thandavarayan, K. Rajagopal, S.S. Jyothula, H. Karmouty-Quintana, Houston, TX, p.A5400 P410 Epithelial Cell Transforming Sequence 2 Contributes to Alveolar Epithelial Cell Reprogramming in Idiopathic Pulmonary Fibrosis/ K. Heinzelmann, H.M. Ulke, K.I.A. Mutze, D.E. Wagner, W. Ren, A. Guenther, O. Eickelberg, M. Koenigshoff, Munich, Germany, p.A5401 P411 DNA-PKcs Modulates Progenitor Cell Proliferation and Fibroblast Senescence in Idiopathic Pulmonary Fibrosis/ M. Hohmann, D.M. Habiel, M.S. Espindola, A.L. Coelho, I.C. Jones, H.D. Jones, R. Carnibella, I. Pinar, F. Werdiger, C.M. Hogaboam, Los Angeles, CA, p.A5402 P412 Dectin-1 Is a Marker of Alternatively Activated Macrophages and a Therapeutic Target in Interstitial Fibrotic Lung Diseases/ M. El Taweel, H. Walker, O. Mekhael, M. Vierhout, M. Padwal, S. Naiel, H. Patel, P. Parthasarathy, J. Imani, E. Ayaub, A. Naqvi, J.A. Hirota, N. Hambly, M.R.J. Kolb, K. Ask, Hamilton, Canada, p.A5403 Facilitator : Y.T. Ghebre, PhD, ATSF, Houston, TX P413 The Neuraminidase 1 (NEU1) - Epidermal Growth Factor Receptor (EGFR) Axis in Pulmonary Fibrosis/ S.P. Atamas, S.W. Hyun, N.W. Todd, S.E. Goldblum, I.G. Luzina, Baltimore, MD, p.A5404 P414 The IRE/XBP1 Pathway Is Activated in Alternatively Activated Macrophages in Interstitial Fibrotic Lung Disease/ M. Vierhout, A. Ayoub, O. Mekhael, M. El-Taweel, M. Padwal, S. Naiel, A. Dvorkin-Gheva, A. Naqvi, N. Hambly, J.A. Hirota, M.R.J. Kolb, K. Ask, Hamilton, Canada, p.A5405 P415 TINCR, a Long Intergenic Noncoding RNA Decreased in IPF, Is a Novel Regulator of Airway Epithelial Cell Differentiation/ N. Omote, K. Sakamoto, Q. Li, J.C. Schupp, T. Adams, F. Ahangari, M. Chioccioli, N. Xylourgidis, G. DeIuliis, N. Hashimoto, Y. Hasegawa, N. Kaminski, New Haven, CT, p.A5406 P416 Deletion of Pou2af1 in Type II Alveolar Epithelial Cells Augments Bleomycin-Induced Pulmonary Fibrosis/ Q. Li, N. Omote, Z. Chen, G. DeIuliis, Z. Zhu, E. Herzog, A. Shakya, D. Tantin, J.D. Herazo-Maya, N. Kaminski, New Haven, CT, p.A5407 P417 EphA3-Expressing Lung Cells Contribute to Fibrosis in IPF/ C.M. Hogaboam, I. Jones, M. Espindola, A.L. Coelho, D. Habiel, Los Angeles, CA, p.A5408 P418 Myeloid-Derived HB-EGF in Pulmonary Fibrosis/ E. Hult, D.N. O’Dwyer, C.A. Wilke, B.B. Moore, Ann Arbor, MI, p.A5409 ATS 2019 • Dallas, TX 280 TUESDAY • MAY 21