ATS 2019 Virtual Final Program

P912 Mechanisms of Acetylcholine-Induced Release of Proinflammatory Extracellular Vesicles by Endothelial Cells and Inhibitory Effects of Tiotropium/ T. Neri, V. Scalise, I. Passalacqua, R. Pedrinelli, P. Paggiaro, A. Celi, Pisa, Italy, p.A5377 P913 Cigarette Smoke Induced Inhibition of Sphingomyelin Synthase 2 Activity Modulates Airway Resistance/ G. Gupta, C.N. Railwah, J. Poon, R. Wadgaonkar, M.A. Salathe, N. Baumlin, C. Huan, R.F. Foronjy, X.-C. Jiang, P. Geraghty, Brooklyn, NY, p.A5378 P914 Inhibition of Nasal and Systemic IgA Responses by Cigarette Smoke Exposure in Mice/ J. McGrath, D. Thayaparan, S. Cass, B. Ly, R. Heo, S. Afkhami, J. Koenig, M. Fantauzzi, L.P. Schenck, M. Stampfli, Hamilton, Canada, p.A5379 P915 PU.1 Mediates Cigarette Smoke Extract Induced Endothelial Progenitor Cell Dysfunction via Stem Cell Antigen-1/ X. He, L. Luo, Y. Chen, Changsha, China, p.A5380 P916 Microarray Analysis of Noncoding RNA in Lung Tissue of COPD Patients/ A. Zhou, Z. Zhou, P. Chen, Changsha, China, p.A5381 P917 NPNT Knock Down Leads to Reveal Function in Human Bronchial Epithelial Cells/ G. Qian, A. Henry, C.K. Billington, B. Liu, B. Kc, I. Sayers, I.P. Hall, Ningbo, China, p.A5382 P918 NEIL2 Activity a Sign of Oxidative Stress in COPD?/ J. Seashore, N. Tapryal, S. Sur, T. Hazra, V.J. Cardenas, Galveston, TX, p.A5383 P919 Elastase Activity as an Indicator of Exacerbation and Disease Severity in COPD/ M. Fischer, A. Kirkman-Thomas, P. Mallia, S.L. Johnston, S. Johnson, Nottingham, United Kingdom, p.A5384 P920 Neutrophil Elastase Activates Macrophages via Integrin-Src Kinase Pathway/ G. Graves, K. Krotova, N. Khodayari, R. Oshins, G. Aslanidi, M. Brantly, Gainesville, FL, p.A5385 Facilitator : S.V. Raju, BPharm, PhD, Birmingham, AL P921 Low Prevalence of Abnormal Alpha-1 Antitrypsin Genotypes in Veterans with COPD/ M.V. Perez, L.V. Luna Diaz, R.A. Calderon Candelario, G.E. Holt, M. Mirsaeidi, M.A. Campos, Miami, FL, p.A5386 P922 The Effects of PDE4 Inhibitors Roflumilast and CHF6001 on Cytokine Production from COPD BAL Lymphocytes/ S. Lea, L. Hodgson, T. Southworth, F. Facchinetti, G. Villetti, M. Civelli, D. Singh, Manchester, United Kingdom, p.A5387 P923 Shared Single Nucleotide Polymorphisms Regulate Gene Expression of Macrophage Migration Inhibitory Factor and D-Dopachrome Tautomerase-Like Protein in Lung Tissue/ L. Florez Sampedro, C.-A.A. Brandsma, M. De Vries, W. Timens, M. Obeidat, P. Joubert, D.C. Nickle, G.J. Poelarends, A. Faiz, B.N. Melgert, Groningen, Netherlands, p.A5388 P924 Single Nucleus Sequencing from Archived Human Lung Tissues/ J.H. Yun, Y. Tang, C. Lee, F. Guo, S.H. Randell, V. Carey, E. Henske, A.X. Zhou, C.P. Hersh, Boston, MA, p.A5389 P925 Functional Characterization of Alveolar Macrophages (AM) Derived from Alpha-1 Antitrypsin (AAT) Deficient (AATD) Human Induced Pluripotent Stem Cells/ A. Mikosz, D. Cao, A.A. Wilson, D.N. Kotton, I. Petrache, K.A. Serban, Denver, CO, p.A7426 P926 Association of Urine Mitochondrial DNA to Outcomes in COPD in the SPIROMICS Cohort/ M.C. Rice, K.T. Schiffer, C. Oromendia, W. Zhang, S.P. Peters, P. Woodruff, C.B. Cooper, R.P. Bowler, A.P. Comellas, G.J. Criner, R. Paine, N.N. Hansel, M.K. Han, R.G. Barr, J.A. Krishnan, M.T. Dransfield, J.L. Curtis, K.V. Ballman, F.J. Martinez, A.M.K. Choi, K. Nakahira, S.M. Cloonan, M.E. Choi,New York, NY, p.A7427 P927 Oral Microbiome Differences Associated with Replacing Tobacco Smoking with Electronic Cigarette Vaping/ M.A. Campos, A.M. Guerrero, R.A. Calderon Candelario, G.E. Holt, M. Mirsaeidi, R. Mendez, M.A. Salathe, V. Perez, S. Benarjee, Miami, FL, p.A7428 P928 Epigenome-Wide Association Study of Exercise Capacity and Physical Activity in COPD/ E.S. Wan, E. Garshick, D.L. DeMeo, M. Moy, Boston, MA, p.A7429 P929 Association of Circulating Cell-Free Mitochondrial DNA to Outcomes in COPD in the SPIROMICS Cohort/ K.T. Schiffer, M.C. Rice, C. Oromendia, W. Zhang, S.P. Peters, P. Woodruff, C.B. Cooper, R.P. Bowler, A.P. Comellas, G.J. Criner, R. Paine, N.N. Hansel, M.K. Han, R.G. Barr, J.A. Krishnan, M.T. Dransfield, J.L. Curtis, K.V. Ballman, F.J. Martinez, K. Naka, A.M.K. Choi, New York, NY, p.A7430 P930 Nicotine Plays a Key Role on Inflammation Driven by Monocyte-Derived-Macrophages of Subjects with Alpha-1 Antitrypsin Deficiency/ L. Benninger, J. Lee, K. Krotova, J. West, J. Lascano, M. Brantly, Gainesville, FL, p.A7431 P931 The Potential Role of Structurally Altered Elastic Fibers in COPD Exacerbation/ S. Mehraban, S. Ma, X. Liu, G. Turino, J. Cantor, Queens, NY, p.A7432 P932 Synthetic Liposome Mimics of Alveolar Macrophage-Derived Vesicles Containing Suppressor of Cytokine Signaling 3: Inhibitors of Lung Tumor Cell Expansion and Potential Therapeutic for Lung Cancer/ J. Speth, L.R.K. Penke, J.D. Bazzill, J.J. Moon, M. Peters-Golden, Ann Arbor, MI, p.A7433 P933 Multiple Single Nucleotide Polymorphisms (SNPs) of the Transient Receptor Potential Vanilloid 1 (TRPV1) Genes Are Associated with Cough Response to Capsaicin in Healthy Subjects/ P. Maestrelli, F. Liviero, M. Campisi, S. Pavanello, Padova, Italy, p.A7434 P934 Prioritizing GWAS SNPs to Guide Functional Genomics of Human Lung Disease/ B. Stubbs, S. Gopaulakrishnan, D.C. Croteau-Chonka, K. Glass, V. Carey, B.A. Raby, Boston, MA, p.A7435 P935 Unsupervised Clustering Reveals Distinct Macrophage Phenotypes Associated with COPD and COPD Exacerbation/ S. Vasudevan, J.J. Vasquez, W.E. Chen, E. Niemi, S. Zeng, M. Arjomandi, San Francisco, CA, p.A7436 ATS 2019 • Dallas, TX TUESDAY • MAY 21 279 TUESDAY MORNING