ATS 2019 Virtual Final Program

P419 Interleukin-8 Release by Endothelial Colony-Forming Cells Isolated from Idiopathic Pulmonary Fibrosis Patients Might Contribute to Their Pathogenicity/ A. Blandinieres, N. Gendron, N. Bacha, I. Bieche, H. Nunes, N. Nevo, E. Rossi, B. Crestani, S. Lecourt, S. Chevret, A. Lokajczyk, A. Kisaoglu, K. Juvin, S. Bertil, D. Valeyre, A. Cras, P. Gaussem, D. Israël-Biet, D.M. Smadja, Paris, France, p.A5410 Facilitator : K. Bernau, DPhil, Madison, WI P420 Therapeutic Anti-Fibrotic Effect of Nintedanib in a Rat Model of Lung Fibrosis Induced by a Double Bleomycin Intratracheal Administration/ V. Pitozzi, P. Caruso, S. Pontis, M.G. Pittelli, M. Bonatti, C. Frati, D. Madeddu, F. Quaini, C. Lagrasta, G. Villetti, M. Civelli, M. Trevisani, Parma, Italy, p.A5411 P421 ATF3 Pleiotropic Functions Over IPF Lung Fibroblast/ T. Cruz, D.M. Alvarez, J. Sembrat, J. Bullock, N. Cardenes, M. Rojas, Pittsburgh, PA, p.A5412 P422 Osteoclast-Like Differentiation in Mouse Model of Silicosis/ Y. Hasegawa, N.M. Nikolaidis, Y. Uehara, L.B. Pitstick, H. Wu, J.C. Gardner, J.G. Noel, E.J.-A. Kopras, J.P. Bridges, F.X. McCormack, Cincinnati, OH, p.A5413 P423 Pirfenidone Therapy Attenuates Lung Function Decline in a Mouse Model of TGF a -Induced Pulmonary Fibrosis/ V. Sontake, D. Soundararajan, J.R. Arron, A. Jegga, S.K. Madala, Cincinnati, OH, p.A5414 P424 Pirfenidone Partially Alleviated Paraquat-Induced Pulmonary Inflammation and Fibrosis in Rats/ Q. Ye, Y. Yan, S. Li, J. Ma, Beijing, China, p.A5415 P425 Pathomechanistic Role of Autophagy in the Development of Lung Fibrosis/ P. Mahavadi, V. Kesireddy, J. Grodtke, J. Knöll, S.P. Chillappagari, M. Korfei, I. Henneke, C. Ruppert, L. Knudsen, A. Guenther, Giessen, Germany, p.A5416 P426 Antisense Oligonucleotide Mediated Reduction of TG2 Attenuates Pulmonary Fibrosis in Mice/ M. Zhang, J.R. Crosby, D. Bai, C. Zhao, A.R. Macleod, S. Guo, Carlsbad, CA, p.A7438 P427 In Vitro Modelling and Characterising of Epithelia-Fibroblast Interactions in Idiopathic Pulmonary Fibrosis/ J.P. Garnett, V. Schroeder, J. Schütt, J. Wirth, M.J. Thomas, F.E. Herrmann, L.H. Quang, Biberach an der Riss, Germany, p.A7439 BASIC • CLINICAL • TRANSLATIONAL THEMATIC POSTER SESSION C65 DIFFUSE PARENCHYMAL LUNG DISEASES: BASIC AND CLINICAL STUDIES 9:15 a.m. - 4:15 p.m. KBHCCD Area G (Hall F, Level 2) Viewing: Posters will be on display for entire session. Discussion: 11:15-12:00: authors will be present for individual discussion 12:00-1:00: authors will be present for discussion with assigned facilitators. Facilitator : J.C. Horowitz, MD, ATSF, Ann Arbor, MI P937 Use of Quantitative CT to Determine Disease Extent and Identify UIP Pattern in Rheumatoid Arthritis ILD/ S.M. Humphries, A.M. Notary, J.P. Centeno, D.A. Lynch, Denver, CO, p.A5417 P938 Micro-Optical Coherence Tomography to Characterize Pharmacologic Induction of Muc5B in WT and Muc5b KO Primary Ferret Bronchial Epithelial Air-Liquid-Interface Cultures/ M. Weupe, J.E. Peabody, S. Phillips, T. Adewale, M. Mazur, S. Moll, N. He, X. Liu, J.F. Engelhardt, B.H. Rosen, S.M. Rowe, Birmingham, AL, p.A5418 P939 Quantitative Image Analysis at the Onset of Chronic Lung Allograft Dysfunction/ S. Weigt, H.D. Jones, G.H. Kim, A.L. Ramsey, B. Villagas, E. Diaz, F. Abtin, M.Y. Shino, A. Derhovanessian, D. Sayah, R. Saggar, J.P. Lynch, J.A. Belperio, D.J. Ross, J. Goldin, Los Angeles, CA, p.A5419 P940 Investigating the Expression of CCL18 in Alternatively Activated Macrophages and in the Progression of Different Fibrotic Lung Diseases/ A. Ayoub, M. Padwal, O. Mekhael, M. Vierhout, M. El-Taweel, S. Naiel, A. Naqvi, J.A. Hirota, N. Hambly, M.R.J. Kolb, K. Ask, Hamilton, Canada, p.A5420 P941 Global Deletion of COMP Does Not Protect from Bleomycin-Induced Pulmonary Fibrosis/ K. Miller, C. Wilson, S. Collum, J. Hecht, H. Karmouty-Quintana, J.L. Alcorn, Houston, TX, p.A5421 P942 Pharmacokinetics and Safety of Pirfenidone Following Inhaled Delivery to Sheep: A Viable Approach to Treating Idiopathic Pulmonary Fibrosis/ M. Surber, L. Kaminskas, C. Landersdorfer, R. Bischof, S. Beck, S. Pham, A. Jain, A. Halvarsson, M. Hug, A.B. Montgomery, San Diego, CA, p.A5422 Facilitator : F. Xu, PhD, Vancouver, Canada P943 Respiratory Assessment Using Intra-Plural Pressure/Head-Out Plethysmography in a Repetitive Bleomycin Challenge Model of Pulmonary Fibrosis in Conscious Rats/ M.C. McElroy, C. Lam, I. Cranston, J. Baily, P. Aston, M. Nandi, A. Milne, Tranent, United Kingdom, p.A5423 P944 Pharmacokinetics and Efficacy of Nintedanib in a Repetitive Bleomycin Challenge Model of Rat Lung Fibrosis/ M.C. McElroy, J. Baily, O. Peris Serrano, A. Marsden, M. Briggs, I. Love, S. Madden, S. Gandi, M. Whitmarsh, A. Young, Tranent, United Kingdom, p.A5424 P945 Pulmonary Function Tests and Connective Tissue Disease Associated with Interstitial Lung Disease: Which Tests Could Better Predict the Extension of Lung Involvement?/ A.M. Lopes, J. Almeida, I. Moreira, T. Sá, S. Rosário, C. Rocha, R.D. Coelho, A. Borba, J. Cardoso, Lisboa, Portugal, p.A5425 P946 Lipid Accumulation Leads to Inhibition of M1 Response in Alveolar Macrophages/ W. Slovinsky, H. Shaghaghi, A. Bhushan, F. Romero, R.S. Summer, Philadelphia, PA, p.A5426 P947 Assessment of Microstructural Changes in Lung Parenchyma of Adolescent Idiopathic Scoliosis Patients Using Proton MRI and Hyperpolarized 3 He MRI/ R.P. Thomen, P. Sturm, V. Jain, L. Walkup, N.S. Higano, J.D. Quirk, J.C. Woods, L. Schultz, L. Benken, K. Krallman, B.M. Varisco, Columbia, MO, p.A5427 ATS 2019 • Dallas, TX TUESDAY • MAY 21 281 TUESDAY MORNING