ATS 2019 Virtual Final Program

Facilitator : B.W. Richmond, MD, PhD, Nashville, TN P889 5’-Aminolevulinate Synthase 2 (ALAS2) Expression Is a Potential Biomarker of Chronic Obstructive Pulmonary Disease (COPD) Cachexia/ A.C. Wilson, P.L. Kumar, M.M. Parker, I. Arora, J.D. Morrow, E.F.M. Wouters, R. Casaburi, S.I. Rennard, D.A. Lomas, A. Agusti, R.M. Tal-Singer, M.T. Dransfield, S.P. Bhatt, V.J. Thannickal, H.K. Tiwari, C.P. Hersh, P.J. Castaldi, E.K. Silverman, M.N. McDonald, Birmingham, AL, p.A5354 P890 Decreased Surfactant Phospholipids in COPD Patients Correlate with Pulmonary Function/ B. Kumley, E. Area-Gomez, Y. Xu, M.A. Campos, R.F. Foronjy, I. Garcia-Arcos, Brooklyn, NY, p.A5355 P891 Cigarette Smoke Exposure Enhances TACC2 Degradation That Leads to Emphysema/ X. Li, M. Rojas, C. Zou, R.A. Lafyatis, R.K. Mallampalli, T. Nyunoya, Pittsburgh, PA, p.A5356 P892 Adaptive NKG2C+ Natural Killer Cells Increase in COPD Patients with Frequent Exacerbations/ S. Pascual-Guardia, I. Ramirez-Martinez, J. Yelamos, M. Lopez-Botet, J. Gea, Barcelona, Spain, p.A5357 P893 Role of Lysocardiolipin Acyltransferase in Lung Epithelial Cell Apoptosis Induced by Cigarette Smoke Extract/ M. Bandela, R.K. Bikkavilli, P. Fu, V. Suryadevara, S. Dhavamani, S. Papasani, S. Singla, S.P. Reddy, S.M. Dudek, V. Natarajan, Chicago, IL, p.A5358 P894 Characterization of Immune Cell Subsets in Blood and Sputum from COPD Patients/ S. Ingersoll, W. LeMaster, R. McGill, L. Daugherty, J. Castaneda, R. Kern, K. Miner, R. Elliot, P. Naman, J.A. Johnston, J.A. Belperio, C.B. Cooper, I. Barjaktarevic, H. Phee, South San Francisco, CA, p.A5359 P895 Systemic Inflammation Is Key to Understanding the Link Between Concomitant Chronic Obstructive Pulmonary Disease and Cardiovascular Disease/ M. Abou Rjeili, R. Farias, C. Baglole, J. Bourbeau, Montreal, Canada, p.A5360 P896 Iron-Responsive Element-Binding Protein 2 (IRP2) Mediates Resistive Breathing-Induced Pulmonary Inflammation/ T. Vassilakopoulos, D. Toumpanakis, V. Vassilakopoulou, E. Mizi, A. Chatzianastasiou, K. Pantopoulos, Athens, Greece, p.A5361 P897 Effects of Long-Acting Bronchodilators on Airway Mucus Quantity and Quality/ H. Aritake, T. Tamada, K. Murakami, S. Gamo, M. Nara, H. Sugiura, M. Ichinose, Sendai, Japan, p.A5362 P898 Expression of Receptor Interacting Protein Kinase-3 and Mixed Lineage Kinase Domain-Like Protein in Patients with COPD/ F. Verhamme, H.P. Van Eeckhoutte, T. Buyle-Huybrecht, G.G. Brusselle, P. Vandenabeele, T. Vanden Berghe, K.R. Bracke, Ghent, Belgium, p.A5363 P899 Telomere Length in COPD: Relationships with Physical Activity, Exercise Capacity and Acute Exacerbations/ E.S. Wan, R. Goldstein, V.S. Fan, H.Q. Nguyen, I. DeVivo, J.E. Hart, E. Garshick, M. Moy, Boston, MA, p.A5364 P900 Chymotrypsin-Like Elastase 1 Is Required for Late Lung Remodeling in Mouse Porcine Pancreatic Elastase Model of Emphysema/ M. Ojha, R. Joshi, J. Lewis, F. Qiang, B.M. Varisco, Cincinnati, OH, p.A5365 P901 The Regulation of NADPH Oxidase Activity by the Protease Inhibitor Alpha-1 Antitrypsin, a Novel Mechanism/ P. Hawkins, D.A. Bergin, T. McEnery, N.G. McElvaney, E.P. Reeves, Dublin, Ireland, p.A5366 P902 Expression of Different VEGF Isoforms and Receptors in Primary Distal Lung Fibroblasts and Lung Explants from Patients with COPD/ M. Boger, C. Müller, S.S. Sohal, E. Tufvesson, O. Hallgren, X.-H. Zhou, L. Bjermer, G. Westergren-Thorsson, M. Schmidt, A.-K. Larsson Callerfelt, Lund, Sweden, p.A5367 P903 CSP7 Mitigates TSE Induced Airway Injury and Susceptibility to Develop Emphysema/ D.N. Das, L. Fan, V. Radhakrishnan, A.S. Marudamuthu, S. Park, R. Shetty, S. Idell, G. Criner, N. Marchetti, S. Bolla, S. Shetty, Tyler, TX, p.A5368 P904 Extracellular Bronchoalveolar Lavage Fluid Ferritin and Risk for Exacerbation in COPD: An Analysis from the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)/ W. Zhang, C. Oromendia, S.A. Kikkers, K. Kim, W.K. O’Neal, C.M. Freeman, S. Christenson, S.P. Peters, J.M. Wells, C.M. Doerschuk, N. Putcha, P. Woodruff, C.B. Cooper, A.P. Comellas, G.J. Criner, R. Paine, N.N. Hansel, M.K. Han, M.K. Han, J.L. Curtis, R.J. Kaner, K.V. Ballman, F.J. Martinez, S.M. Cloonan, New York, NY, p.A5369 Facilitator : Z. Zhu, MD, PhD, Providence, RI P905 Prostaglandin A 2 -Mediated Activation of the Nuclear Receptor Nur77 in Lung Diseases/ A. Reddy, S. Lakshmi, A. Banno, R.C. Reddy, Pittsburgh, PA, p.A5370 P906 Serum Levels of the COPD-Biomarker sRAGE Strongly Correlate with Specific Phenotypes and the Progression of Emphysema/ S.D. Pouwels, F. Klont, M.D. Kwiatkowski, J.-P. Charbonnier, E. van Rikxoort, R.P. Bowler, R. Bischoff, N.H.T. ten Hacken, Groningen, Netherlands, p.A5371 P907 Role of Human SP-D Genetic Variants in the Pathogenesis of Chronic Lung Injury/ L. Ni, Syracuse, NY, p.A5372 P908 Glucosylceramide Regulates Autophagic Flux and Protects Against Cigarette Smoke Induced Cell Death in Lung Endothelial Cells/ K. Koike, E.V. Berdyshev, A.M. Mikosz, I.A. Bronova, E.L. Beatman, J.P. Jung, K. Ni, D. Cao, A.K. Scruggs, I. Petrache, Denver, CO, p.A5373 P909 Protective Role of D-Dopachrome Tautomerase (MIF2) in Chronic Obstructive Pulmonary Disease/ T. Ardito, J. Nouws, S.-J. Kim, Y. Zhang, R. Bucala, P. Lee, M. Sauler, New Haven, CT, p.A5374 P910 MicroRNA Regulation of Cell Fate in the Pathogenesis of COPD/ M. Sauler, J. Nouws, W. Feng, P. Lee, New Haven, CT, p.A5375 P911 Nontypeable Haemophilus Influenzae (NTHi) Exploits Disease-Related Defects in Xenophagy to Persist and Traffic Within the Epithelial Compartment During COPD/ E. Roscioli, M. Poh, A. Kicic, S.E. Lester, P. Nguyen, H.P.A. Jersmann, P.N. Reynolds, S. Hodge, Adelaide, Australia, p.A5376 ATS 2019 • Dallas, TX 278 TUESDAY • MAY 21