ATS 2019 Virtual Final Program

P376 In Vitro Targeting of Collagen Prolyl-4-Hydroxylase in Human Lung Fibroblasts/ A.R. Savage, B. Summers, B. Gary, R.B. Silver, New York, NY, p.A5336 P377 MARCKS Phosphorylation Modulates Cigarette Smoke-Associated Fibrogenic Activities of Lung Fibroblasts/ D.C. Yang, J. Xu, J. Oldham, R. Wu, C.-H. Chen, Davis, CA, p.A5337 Facilitator: A.E. Samarasinghe, PhD, Memphis, TN P378 Monocarboxylate Transporter (MCT) Proteins as Targets for Radiation-Induced Pulmonary Fibrosis/ M. Palmer, Rochester, NY, p.A5338 P379 Extracellular Heat Shock Protein 90 a Interacts with Endoplasmic Reticulum Stress to Promote Pulmonary Fibrosis Via the Toll-Like 4 Receptor Signaling Pathway/ H. Dong, J. Zhang, X. Wan, W. Zhong, C. Ye, S. Cai, Guangzhou, China, p.A5339 P380 Iron-Responsive Element Regulatory System in Idiopathic Pulmonary Fibrosis/ C. Huang, L. Liu, Stillwater, OK, p.A5340 P381 Direct Reprogramming of Mouse Fibroblasts into Pulmonary Epithelial-Like Cells/ T. Kusumoto, M. Ishii, M. Yotsukura, A.E. Hegab, F. Saito, J. Hamamoto, T. Asakura, H. Kamata, H. Namkoong, S. Suzuki, S. Okamori, T. Ogawa, M. So, H. Asamura, M. Ieda, T. Betsuyaku, Tokyo, Japan, p.A5341 P382 De Novo Proline Synthesis Promotes Collagen Production in Human Lung Fibroblasts/ R.B. Hamanaka, E.M. O’Leary, L.J. Witt, R. Nigdelioglu, Y. Tian, A.Y. Meliton, P.S. Woods, K.A. Sun, L.M. Kimmig, G. Gokalp, D. Wu, N.O. Dulin, G.M. Mutlu, Chicago, IL, p.A5342 P383 Metabolic Regulation of Fibroblast Phenotype During Lung Fibrosis by ATP Citrate Lyase/ S.R. Smith, A. Kurundkar, N.J. Logsdon, M.L. Locy, V.J. Thannickal, Birmingham, AL, p.A5343 P384 Glutamine Metabolism Supports Collagen Protein Synthesis in Human Lung Fibroblasts/ E. O’Leary, R.B. Hamanaka, L.J. Witt, R. Nigdelioglu, Y. Tian, A.Y. Meliton, P.S. Woods, K.A. Sun, L.M. Kimmig, D. Wu, G.A. Gokalp, N.O. Dulin, G.M. Mutlu, Chicago, IL, p.A5344 P385 Antifibrotic Efficacy of Nintedanib in a Cellular Model of Scleroderma Associated Interstitial Lung Disease/ G.S. Bogatkevich, T. Akter, I. Atanelishvili, A. Noguchi, S.L. Wollin, R.M. Silver, Charleston, SC, p.A5345 P386 RNA Sequencing of IPF Fibroblasts Demonstrates the Impact of In-Vitro Isolation Methodology on the Senescent Phenotype/ L. Rodriguez, R. Ammar, B. Sobieski, S. Bui, T. John, G. Trujillo, S.D. Nathan, G. Grant, Fairfax, VA, p.A5346 P387 NOX1 Attenuates Mesothelial-Mesenchymal Transition Through Modulation of ROS Mediated Signaling/ T.A. Tucker, O. Ogunsakin, A. Jeffers, S. Owens, W. Qin, S. Komatsu, M. Ikebe, S. Idell, Tyler, TX, p.A5347 Facilitator: D. Lagares, PhD, MSc, Charlestown, MA P388 Myocardin Is Involved in Mesothelial-Mesenchymal Transition of Human Pleural Mesothelial Cells/ T.A. Tucker, Y. Tsukasaki, T. Sakai, S. Mitsuhashi, A. Jeffers, S. Idell, M. Ikebe, Tyler, TX, p.A5348 P389 Single Cell RNA-seq Reveals the Genetic Programs of Invasive Lung Fibroblasts/ X. Liu, Y. Geng, J. Liang, N. Deng, Y. Wang, G. Huang, F. Taghavifar, T. Xie, N. Liu, K. Vrishika, J. Tang, P.W. Noble, D. Jiang, Los Angeles, CA, p.A5349 P390 Sustained SMAD2 Phosphorylation Is Required for Myofibroblast Transformation in Response to TGF-beta/ N.O. Dulin, S. Ard, E. Reed, L. Smolyaninova, S.N. Orlov, R. Guzy, G.M. Mutlu, Chicago, IL, p.A5350 P391 Targeting TBK1 to Reduce Fibroblast Activation/ A. Aravamudhan, A. Haak, G. Ligresti, J.A. Meridew, N. Caporarello, D. Jones, Q. Tan, D.J. Tschumperlin, Rochester, MN, p.A5351 P392 Inhibition of Profibrotic Signaling in Primary Fibroblasts from Patients with Idiopathic Pulmonary Fibrosis (IPF) by Sirtuin-1/-2-Inhibitor Sirtinol/ M. Korfei, J.V. Zlotkowski, D. Stelmaszek, C. Ruppert, W. Seeger, A. Guenther, Giessen, Germany, p.A5352 P393 Telomerase Reverse Transcriptase Regulates CDKN2A and ACTA2 Expression in Fibroblasts/ M. Harada, T. Liu, B. Hu, Z. Wu, S.H. Phan, Ann Arbor, MI, p.A5353 P394 Glucocorticoid Dependent Mesenchymal Cell Differentiation Is Required for Perinatal Lung Morphogenesis and Lung Function/ P. Sudha, D. Lipps, M. Guo, Y. Du, K. Brown, A. Filuta, C. Stockman, X. Chen, J.A. Whitsett, M.T. Weirauch, J.P. Bridges, Y. Xu, Cincinnati, OH, p.A7422 P395 De-Differentiation of Human Lung Myofibroblasts by FGF2 and PGE2 Involves Accelerated Degradation of a SMA mRNA/ S.M. Fortier, L.R.K. Penke, M. Peters-Golden, Ann Arbor, MI, p.A7423 P396 The Possible Effects of Epigallocatechin Gallate on Pulmonary Fibroblasts of Idiopathic Pulmonary Fibrosis - The MicroRNA-Associated Gene Expression Alterations/ P.-L. Kuo, M.-J. Tsai, W.-A. Chang, L. Ssu-Hui, C.-C. Sheu, Kaohsiung, Taiwan, p.A7424 P397 Differential Expression of MicroRNA in Rat Mesenchymal Stromal Cell Derived Extracellular Vesicles Compare to Rat Lung Fibroblasts Derived Extracellular Vesicles/ C. Chetty, R.K. Braun, T.E. Schmitt, E.M. Pellmann, V. Balasubramaniam, Madison, WI, p.A7425 BASIC • TRANSLATIONAL THEMATIC POSTER SESSION C63 MECHANISTIC STUDIES IN COPD 9:15 a.m. - 4:15 p.m. KBHCCD Area F (Hall F, Level 2) Viewing: Posters will be on display for entire session. Discussion: 11:15-12:00: authors will be present for individual discussion 12:00-1:00: authors will be present for discussion with assigned facilitators. ATS 2019 • Dallas, TX TUESDAY • MAY 21 277 TUESDAY MORNING