ATS 2019 Virtual Final Program

Facilitator : F.J. Hawkins, MBBCh, Boston, MA P780 Neutrophil-Derived Microvesicles as a Novel Biomarker in Hyperoxic Bronchopulmonary Dysplasia in Mice/ S. Matsumoto, Y. Iki, M. Abe, K.P. O’Dea, H. Shigemitsu, M. Takata, K. Wakabayashi, Tokyo, Japan, p.A5317 P781 A Novel Examination of a Preterm Lung: Unexpected Predominance of Man9 N-glycan/ J.E. Baatz, R.M. Ryan, H. Kelley, P. Ward, D. Spyropoulos, R. Drake, P. Angel, Charleston, SC, p.A5318 P782 Updates on Lung Gene Expression Analysis (LGEA Web Portal)/ Y. Du, W. Ouyang, J. Kitzmiller, J.A. Whitsett, Y. Xu, Cincinnati, OH, p.A7417 P783 Generation of Phenotype-Stable Alveolar Epithelial Type II Cell from Human Induced Pluripotent Stem Cells/ R. Kim, R. Petrut, H. Zhang, Toronto, Canada, p.A7418 P784 Blockade of Gastrin-Releasing Peptide in Newborn Mice Exposed to 75% O2 for 18 Days Alters Gene Expression Associated with Pulmonary Fibrosis/ C. Cambey, M.E. Sunday, Poughkeepsie, NY, p.A7419 P785 Comparing Myosin Light Chain Kinase Levels in the Tracheal Aspirates of ELBW Infants with and Without BPD/ S. Rajbhandari, S. Amatya, M. Salton, V. Trinh, L.A. Parton, Valhalla, NY, p.A7420 P786 All Trans-Retinoic Acid Modifies the Response of A549 Alveolar Epithelial Cells to Hyperoxia/ I. Ahmed, P. Silveyra, Z.C. Chroneos, T. Umstead, S. DiAngelo, Y. Imamura, Hershey, PA, p.A7421 BASIC • TRANSLATIONAL THEMATIC POSTER SESSION C62 FIBROBLAST BIOLOGY 9:15 a.m. - 4:15 p.m. KBHCCD Area C (Hall F, Level 2) Viewing: Posters will be on display for entire session. Discussion: 11:15-12:00: authors will be present for individual discussion 12:00-1:00: authors will be present for discussion with assigned facilitators. Facilitator : R. Guzy, MD, PhD, Chicago, IL P359 Inhibition of Myofibroblast Differentiation Targeting Multiple Pathways with Pirfenidone and Ogerin/ T. Bell, D. Nagel, R. Clough, P.J. Sime, R.M. Kottmann, Rochester, NY, p.A5319 P360 Integrin A5 (ITGA5) Promotes Cellular Responses Facilitating Idiopathic Pulmonary Fibrosis (IPF) Progression/ G. Epstein Shochet, E. Brook, E. Edelstein, O. Wand, D.A. King, D. Shitrit, Kfar Saba, Israel, p.A5320 P361 Nintedanib Blocks the IPF-Fibroblast Paracrine Induction of Epidermal Growth Factor Receptor/ G. Epstein Shochet, E. Brook, E. Edelstein, O. Wand, D.A. King, S.L. Wollin, D. Shitrit, Kfar Saba, Israel, p.A5321 P362 Members of the Microrna Cluster 17-92 Are Disease Specifically Regulated in Fibroblasts of Idiopathic Pulmonary Fibrosis/ C. Lambers, S. Blumer, F. Lei, P. Jaksch, W. Klepetko, M. Tamm, M. Roth, Vienna, Austria, p.A5322 P363 Cigarette Smoke Extract Promotes Human Lung Myofibroblast Differentiation by the Induction of Endoplasmic Reticulum Stress/ M. Song, H. Peng, W. Guo, M. Luo, W. Duan, P. Chen, Y. Zhou, Changsha, China, p.A5323 P364 Homer1 Is Increased in Idiopathic Pulmonary Fibrosis and Affects Fibroblasts Behavior/ M. Negreros, M. Maldonado, Y.I. Balderas-Martinez, J. Cisneros, C. Mendoza-Milla, M. Selman, A. Pardo, Mexico, Mexico, p.A5324 P365 The Large Conductance Potassium (BK) Channel Increases Calcium Signaling, Fibroblast Proliferation and Mitochondrial Dysfunction in Normal and IPF Fibroblasts/ A. Scruggs, D. Beard, J. Anumonwo, S.K. Huang, Ann Arbor, MI, p.A5325 P366 Wnt1-Inducible Signaling Protein 1 (WISP1) Augments Nuclear Factor (NF)-kB Signaling in Primary Human Lung Fibroblasts/ M. Lehmann, S. Klee, D.E. Wagner, M. Koenigshoff, Munich, Germany, p.A5326 P367 VEGF Down-Regulates OGR1 in Pulmonary Fibrosis and Induces Myofibroblast Differentiation/ S. Baah, D. Nagel, R. Clough, A.R. Rackow, R.M. Kottmann, Rochester, NY, p.A5327 Facilitator : Y. Sanders, MD, Birmingham, AL P368 Role of Galectin-3 in Idiopathic Pulmonary Fibrosis Development/ N.R. Parmar, A.C. Mackinnon, F. Zetterberg, P. Ford, R.G. Jenkins, Nottingham, United Kingdom, p.A5328 P369 Alteration of CK2/XRCC1-Dependent DNA Repair Activity in Apoptosis-Resistant Lung Fibroblasts Could Be a Risk Factor for IPF/ R. Nho, J. Im, Minneapolis, MN, p.A5329 P370 Nintedanib: A Potent Inhibitor of Invadosome Formation by Lung Fibroblasts Derived from Patients with Idiopathic Pulmonary Fibrosis/ M. Lebel, D. Cliche, M. Charbonneau, G. Bilodeau, A.M. Cantin, C.M. Dubois, Sherbrooke, Canada, p.A5330 P371 Overexpression of Twist1 in COL1A2+ Cells Leads to Increased Bleomycin-Induced Pulmonary Fibrosis/ J. Tan, J. Dutta, H. Bahudhanapati, D. Kass, Pittsburgh, PA, p.A5331 P372 Blockade of MicroRNA 144-3p in IPF Lung Fibroblasts Increases Expression of the Relaxin Receptor, RXFP1/ H. Bahudhanapati, J. Tan, J. Dutta, S. Strock, J. Sembrat, D.M. Alvarez, M. Rojas, Y. Zhang, D. Kass, Pittsburgh, PA, p.A5332 P373 Elastin Degradation Products Induce Myofibroblast Differentiation/ D. Nagel, R. Clough, P.J. Sime, R.M. Kottmann, Rochester, NY, p.A5333 P374 Mechanisms of the Anti-Fibrotic Effects of Pirfenidone/ K.G. Dsouza, N.J. Logsdon, D. Chanda, D. Kurundkar, V.J. Thannickal, Birmingham, AL, p.A5334 P375 Lung Resident Mesenchymal Stem Cells Give Rise to Lung Epithelial Progenitor-Like Cells In Vitro/ P. Khan, M. Boesch, L. Fang, M. Tamm, M. Brutsche, F. Baty, K.E. Hostettler, Basel, Switzerland, p.A5335 ATS 2019 • Dallas, TX 276 TUESDAY • MAY 21