ATS 2019 Virtual Final Program

P350 a 1G T-Type Calcium Channel Determines the Angiogenic Potential of Pulmonary Microvascular Endothelial Cells/ Z. Zheng, H. Chen, P. Xie, C.A. Dickerson, J. King, M.F. Alexeyev, S. Wu, Birmingham, AL, p.A5301 P351 Vascular Rarefaction and Loss of Endothelial Identity Accompanies Persistent Fibrosis in Bleomycin-injured Aged Mice/ N. Caporarello, A. Aravamudhan, J.A. Meridew, T. Qi, D.J. Tschumperlin, G. Ligresti, Rochester, MN, p.A5302 P352 Single Cell Metabolism with Deep Learning Reveals That a RhoA-Mediated Glycolytic Burst Drives Endothelial Cell Contractions/ D. Wu, D. Harrison, G.M. Mutlu, J. Huang, Y. Fang, Chicago, IL, p.A7411 P353 Dissecting the Targeted Shp2 Phosphatase in Endothelium During Radiation-Induced Pulmonary Fibrosis/ P. Liu, M. Li, Z. Zhou, H. Cheng, X. Zhang, Y. Ke, HangZhou, China, p.A7412 P354 Delta Like 4 (DLL4), an Endothelial Specific Notch Ligand Is Critical for Lung Vascular Arborization and Alveolarization/ V. Sampath, H. Menden, N. Townley, S. Mabry, M. Nyp, D. Thibeault, S. Xia, Kansas City, MO, p.A7413 P355 Single Cell RNA Sequencing to Characterize Murine Alveolar Macrophages in Control, Schistosomiasis, and Hypoxia Exposures/ N. Campbell, C. Mickael, R. Kumar, M. Frid, K. Stenmark, B. Graham, Aurora, CO, p.A7414 P356 Sphingosine-1-Phosphate Lyase Inhibition Improves Pulmonary Endothelial Cell Survival/ E.L. Beatman, A. Scruggs, K. Koike, K. Schweitzer, E. Berdyshev, I. Petrache, Denver, CO, p.A7415 P357 Sodium Tanshinone IIA Sulfonate Inhibits the Protein Degradation, Promotes the Cell Surface Localization of BMPRII and Restores BMP9 Signaling Transduction in Pulmonary Arterial Endothelial Cells/ K. Yang, W. Liu, W. Lu, J. Wang, Guangzhou, China, p.A7416 BASIC • TRANSLATIONAL THEMATIC POSTER SESSION C61 LUNG DEVELOPMENT, BPD, AND STEM CELLS 9:15 a.m. - 4:15 p.m. KBHCCD Area E (Hall F, Level 2) Viewing: Posters will be on display for entire session. Discussion: 11:15-12:00: authors will be present for individual discussion 12:00-1:00: authors will be present for discussion with assigned facilitators. Facilitator : D. Al Alam, PhD, MS, Los Angeles, CA P766 Isolation and Identification of Epithelial and Endothelial Cells During Mouse Lung Development/ C. Barazzone Argiroffo, S. Blaskovic, I. Ruchonnet-Métrailler, J. Lascano Maillard, Y.R. Donati, Geneva, Switzerland, p.A5303 P767 Human Mesenchymal Stem Cells Phenotype to Define Clinical Potency/ M.Y. Prero, T.M. Raffay, P. MacFarlane, R.A. Somoza, A.I. Caplan, T.L. Bonfield, Cleveland, OH, p.A5304 P768 Amniotic Fluids as a Source of Lung Progenitors for Lung Regeneration/ C. Tiozzo, P. Aguiari, X. Lin, N. Hanna, L. Perin, New York, NY, p.A5305 P769 Multipotent Cell Populaton in the Mouse Placenta: Potential for Lung Epithelial, Cardiomyocyte, and Neuronal Cell Differentiation/ J. Han, M. Hou, S. Emani, J.-A. Park, S.M. Emani, I.O. Rosas, M.A. Perrella, X. Liu, Boston, MA, p.A5306 P770 Mesenchymal Stem Cell Anti-Microbial and Anti-Inflammatory Therapeutic Optimization Through Effector Manipulation/ T.L. Bonfield, M.T. Sutton, M. Majumder, J. Jensen, M. Folz, R. Somoza, A.I. Caplan, Cleveland, OH, p.A5307 P771 The Functional Role of Brain-Derived Neurotrophic Factor (BDNF)-Pathway in the Homeostasis of Alveolar Epithelial Cells and in the Pathogenesis of Bronchopulmonary Dysplasia/ L. Fahle, C. Vohlen, D. Hirani, J. Dötsch, M.A. Alejandre Alcazar, Cologne, Germany, p.A5308 P772 Hydroxymethylation and Ten-Eleven Translocation Levels in a Mouse Model of Bronchopulmonary Dysplasia/ J.L. Davies, H. Li, M. Lee, Y. Huang, Houston, TX, p.A5309 Facilitator: D.T. Swarr, MD, Cincinnati, OH P773 The Role of Hyperoxic Tracheobronchial Ciliary Dysfunction in the Pathogenesis of Bronchopulmonary Dysplasia/ D. Teape, D. Bhaskar, P.A. Dennery, Providence, RI, p.A5310 P774 Hyperoxia Leads to Early Senescence in Neonatal Lungs and Lung Epithelial Cells: Consequences for Alveolar Simplification/ P.A. Dennery, A. Peterson, S. Bullock, A. Scaffa, Providence, RI, p.A5311 P775 Extracellular Superoxide Dismutase (EC-SOD) Knockout Mice Have Worse Alveolarization, Inflammation and Cytokine Elaboration After Neonatal Hyperoxia Exposure/ C. Longoria, J. Ibrahim, J. Liao, N. Cheong, E.N. Grayck, R.C. Savani, Dallas, TX, p.A5312 P776 Oral Maternal Administration of the Cytochrome P450 (CYP)1A/1B Inducer, Beta-Napthoflavone (BNF), Attenuates Oxygen-Mediated Lung Injury in Newborn Mice: Implications for Bronchopulmonary Dysplasia (BPD)/ X. Couroucli, Y.W. Liang, K. Lingappan, P. Maturu, W. Jiang, B. Moorthy, Houston, TX, p.A5313 P777 Adrenomedullin Deficiency Potentiates Lipopolysaccharide-Induced Experimental Bronchopulmonary Dysplasia in Neonatal Mice/ B. Shivanna, A. Shrestha, R. Menon, Houston, TX, p.A5314 P778 Integrative Epigenomic/Transcriptomic Analysis of Sex-Biased Differences in in a Murine Model of Neonatal Hyperoxic Lung Injury/ K. Lingappan, T. Katz, R. Kumar, C. Walker, B. Moorthy, C. Coarfa, Houston, TX, p.A5315 P779 The Receptor for Hyaluronan-Mediated Motility (RHAMM, CD168) Contributes to the Development of Bronchopulmonary Dysplasia/ I.-C. Chen, J. Liao, N. Cheong, C.L. Longoria, R.C. Savani, Kaohsiung, Taiwan, p.A5316 ATS 2019 • Dallas, TX TUESDAY • MAY 21 275 TUESDAY MORNING