ATS 2019 Virtual Final Program

BASIC • TRANSLATIONAL THEMATIC POSTER SESSION C60 VASCULAR BIOLOGY IN LUNG DISEASE 9:15 a.m. - 4:15 p.m. KBHCCD Area C (Hall F, Level 2) Viewing: Posters will be on display for entire session. Discussion: 11:15-12:00: authors will be present for individual discussion 12:00-1:00: authors will be present for discussion with assigned facilitators. Facilitator : K. Suresh, MD, Baltimore, MD P327 Role of Pyruvate Kinase 2 Muscle (PKM2) Oligomerization in Pulmonary Arterial Hypertension/ N. Rai, T. Novoyatleva, N. Weissmann, H.-A. Ghofrani, R.T. Schermuly, W. Seeger, Giessen, Germany, p.A5278 P328 Gremlin-1 Modulates Macrophage Polarization/ L. Mthunzi, S.C. Rowan, L. Piouceau, S. Devlin, U. Knaus, P. McLoughlin, Dublin, Ireland, p.A5279 P329 New Insights into Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension: Potential Role for EBP50/ A. Gorelova, V. Negi, A. Alsuraimi, Y. Tang, S.Y. Chan, I. Al Ghouleh, Pittsburgh, PA, p.A5280 P330 Senescent Cells Protect Against Pulmonary Hypertension Development in Mice/ E. Born, M. Breau, S. Abid, A. Houssaini, D. Beaulieu, E. Marcos, R. Pierre, M. Do Cruzeiro, S. Adnot, Creteil, France, p.A5281 P331 Endothelial Inflammatory Signaling Suppresses MDSC-Mediated Pulmonary Vascular Remodeling/ A.J. Bryant, C. Fu, Y. Lu, M. Williams, M. Brantly, E. Scott, Gainesville, FL, p.A5282 P332 Inhibition of Janus Kinase 2 -Signal Transducer and Activator of Transcription 3 (JAK2-STAT3) Pathway as a Therapeutic Option for Pulmonary Hypertension/ N.D.R. Yerabolu, A. Weiss, N. Weissmann, H.A. Ghofrani, F. Grimminger, W. Seeger, R.T. Schermuly, Giessen, Germany, p.A5283 P333 The Emerging Role of Gas6/Axl Axis in Pulmonary Arterial Hypertension/ T. Novoyatleva, N. Rai, B. Kojonazarov, F. Grimminger, H.-A. Ghofrani, N. Weissmann, W. Seeger, R.T. Schermuly, Giessen, Germany, p.A5284 P334 N-Lysine Methyltransferase SMYD2-Mediated Methylation Enhances HIF-1 a Stability and Pro-Angiogenic Signaling/ S. Veeroju, A. Ashir, A. Mamazhakypov, B. Kojonazarov, J. Wilhelm, H.A. Ghofrani, N. Weissmann, W. Seeger, R.T. Schermuly, T. Novoyatleva, Giessen, Germany, p.A5285 P335 Balance Between Lung Endothelial Cell Injury and Repair Defines the Pulmonary Hypertension Phenotype in a Targeted Transgenic Model of Diptheria Toxin-Induced Apoptosis/ R. Soares Godoy, M. Taha, Y. Deng, K. Rowe, D.J. Stewart, Ottawa, Canada, p.A5286 P336 Emerging Role of Adenylate Kinase 4 as a Metabolic Player Regulating Cellular Hypoxic Responses in Pulmonary Cells/ M. Wujak, M. Brosien, C.Y. Wu, R.T. Schermuly, H.A. Ghofrani, W. Seeger, F. Grimminger, O. Pak, N. Weissmann, Giessen, Germany, p.A5287 Facilitator: R.F. Hough, MD, PhD, New York, NY P337 Overexpression of Hypoxia Inducible Factors in Pulmonary Artery Smooth Muscle Cells Mitigates Hypoxia-Induced Pulmonary Hypertension/ E.A. Barnes, X. Che, R. Ito, S. Reddy, D.N. Cornfield, Stanford, CA, p.A5288 P338 Role of Interstitial Macrophages in Hypoxia-Induced Pulmonary Hypertension/ R. Kumar, C. Mickael, B. Kassa, L. Sanders, S. Kumar, W.J. Janssen, K.R. Stenmark, R.M. Tuder, B.B. Graham, Aurora, CO, p.A5289 P339 The EH-Induced Mouse Model of Pulmonary Arterial Hypertension Recapitulates Gender Differences of Human Disease/ S.A. Predescu, B. Carman, S. Qin, D.N. Predescu, Chicago, IL, p.A5290 P340 Single Cell Sequencing and Lineage Tracing of Pulmonary Vasculature Development/ S. Hon, A.E. Engler, H.M.K. Richardson, J.R. Rock, Boston, MA, p.A5291 P341 BMPR2 Alternative Splicing in Pulmonary Endothelial Cells Is Involved in the Pathobiology of Heritable PAH/ G. Manaud, Le Plessis-Robinson, France, p.A5292 P342 Smooth Muscle Enriched Long Noncoding RNA (SMILR) Is Implicated in the Progression of Pulmonary Hypertension/ T. Mertens, S. Collum, C. Wilson, B. Weizhen, R. Thandavarayan, A. Guha, M.R. Blackburn, H. Karmouty-Quintana, Houston, TX, p.A5293 P343 Alternative Polyadenylation of TGF-ß Pathway Components Modulates Pulmonary Hypertension/ S. Collum, T. Mertens, C. Wilson, L. Zhu, T.W. Mills, R.T. Thandavarayan, A. Guha, W. Zheng, M.R. Blackburn, H. Karmouty-Quintana, Houston, TX, p.A5294 P344 The Enah/ VASP Like Protein Is Involved in Vascular Remodeling at the Lamellipodia in Endothelial Cells/ J.B. Mascarenhas, S.M. Novak, R.M. Mayfield, K.A. Zarate, T.R. Mendoza, C.C. Gregorio, J.G.N. Garcia, Tucson, AZ, p.A5295 P345 Molecular Mechanism by Which RHAMM Activates Src Kinase and the Signaling Pathway for Nitric Oxide Production in the Endothelium/ N. Cheong, I. Yuhanna, Q. Wu, V. Ulrich, J. Liao, C. Longoria, P.W. Shaul, R.C. Savani, Dallas, TX, p.A5296 P346 Adenosine Improves Pulmonary Artery Vasa Vasorum Barrier Function in Ph Via Atypical A1 Receptor-Mediated Signaling Mechanisms/ A.D. Verin, R. Batori, A. Kovacs-Kasa, M. Cherian-Shaw, S. Kumar, V. Karoor, D. Strassheim, K.R. Stenmark, E.V. Gerasimovskaya, Augusta, GA, p.A5297 Facilitator : A. Sarkar, PhD, Columbus, OH P347 Transfusion of Red Blood Cells in Mice with Endothelial Deletion of the S-Nitrosothiol Transporter LAT1/ H. Zhu, I. Akosman, T.J. McMahon, Durham, NC, p.A5298 P348 Independent and Interactive Effects of Early Lipopolysaccharide and Hyperoxia Exposure on Pulmonary Vasculature and Right Ventricle of Neonatal Mice/ B. Shivanna, R. Menon, A. Shrestha, C. Reynolds, Houston, TX, p.A5299 P349 Multi-Transcriptome-Based Network Analysis to Identify Novel Genes and Candidate Small Molecules for Pulmonary Arterial Hypertension/ S. Ghandikota, M. Lape, A. Jegga, Cincinnati, OH, p.A5300 ATS 2019 • Dallas, TX 274 TUESDAY • MAY 21