ATS 2019 Virtual Final Program

406 The Human Microbiome in Critical-Illness: Longitudinal Evolution of Oral, Lung and Gut Communities in Mechanically-Ventilated Patients and Association with Clinical Outcomes/ G. Kitsios, R. Nettles, L. Yang, K. Fair, S. Qin, A. Fitch, X. Wang, J. Evankovich, W. Bain, D.G. Dunlap, F. Shah, S. Rapport, K. Li, B. Methe, J. Lee, A.M. Morris, B.J. McVerry, Pittsburgh, PA, p.A4214 407 Lower Airway Priming with Human Oral Commensals Alters Immune Response to Streptococcus Pneumoniae/ L. Perez, B. Wu, I. Sulaiman, B. Franca, J. Carpenito, E. Olsen, K. Yie, S. Ma, A. Gonzalez, Y. Li, J.J. Tsay, L.N. Segal, New York, NY, p.A4215 408 COPD Upper Airway Microbiome Is Associated with Age and Obstruction Severity/ A. Pragman, K.A. Knutson, T.J. Gould, S. Hodgson, R.E. Isaacson, C.S. Reilly, C.H. Wendt, Minneapolis, MN, p.A4216 409 Metatranscriptomic Reveals Functional Abnormalities of Lower Airway Dysbiosis Signatures Identified in Humans/ I. Sulaiman, B. Wu, J. Tsay, Y. Li, A.S. Scott, E. Olsen, A. Gonzalez, K. Gershner, J. Clemente, E. Ghedin, L.N. Segal, New York, NY, p.A4217 410 Effects of Nasal Alkalinization on Bacterial Colonization in Healthy Subjects/ Z. Holliday, J.L. Launspach, L. Durairaj, M. Abou Alaiwa, D.A. Stoltz, J. Zabner, Iowa City, IA, p.A4218 411 Bacterial Etiology of Community-Acquired Pneumonia and Appropriateness of Empirical Treatment Recommendations: An International Observational Cohort Study/ M. Carugati, S. Aliberti, F. Blasi, A. Gori, M.I. Restrepo, Milano, Italy, p.A4219 412 Longitudinal Multidimensional Phenotyping of the Alveolar Microenvironment in Critically Ill Patients with Pneumonia: Feasibility of the Successful Clinical Response in Pneumonia Therapy (SCRIPT) Trial/ J.M. Walter, J.M. Kruser, C. Pickens, H. Donnelly, N. Borkowski, B.D. Singer, A. Hauser, D.R. Winter, P. Seed, A. Misharin, G.S. Budinger, R.G. Wunderink, Chicago, IL, p.A4220 413 C-Reactive Protein of 15 mg/dl on Admission Is Associated with Prolonged Length of Stay in Patients Hospitalized with Community-Acquired Pneumonia/ Y. Genchanok, J. Ognibene, W. Southern, S. Arora, Bronx, NY, p.A4221 414 Addition of C-Reactive Protein to Pneumonia Severity Index Better Predicts Length of Stay in Hospitalized Patients with Community-Acquired Pneumonia/ Y. Genchanok, J. Ognibene, W. Southern, S. Arora, Bronx, NY, p.A4222 415 Inaccurate Empiric Antibiotic Selection in Severe Pneumonia in the Intensive Care Unit/ J. Bailey, M.T. Bender, M.S. Niederman, New York, NY, p.A4223 416 Benefit Versus Harm of Empiric Anti-MRSA Therapy in Hospitalized Patients with Pneumonia/ B.E. Jones, J. Ying, V. Stevens, T. He, B. Sauer, A.D. Bostwick, M. Jones, M. Samore, T. Greene, Salt Lake City, UT, p.A4224 417 Where’s the Sweet Spot? Exploring the Impact of Varying Antibiogram Thresholds to Guide Broad-Spectrum Antibiotic Use in Hospital Acquired Pneumonia/ A.D. Bostwick, B.E. Jones, M. Goetz, M. Samore, R. Paine, M. Jones, Salt Lake City, UT, p.A4225 418 A Stepwise Approach Using Nares MRSA PCR Test to Prevent Overuse of Vancomycin in CAP Patients Admitted to ICU/ R. Estrada Anzueto, D. Villafuerte, J. Villalpando, K. Echevarria, K. Morneau, T. Hopkins, E. Walter, A. Anzueto, M.I. Restrepo, San Antonio, TX, p.A4226 419 Plasma Beta-D-Glucan Levels Are Associated with Host Inflammation and Injury and Clinical Outcomes in Mechanically-Ventilated Adult Patients/ D. Kotok, M. Finkelman, Y. Zhang, J. Evankovich, W. Bain, D.G. Dunlap, F. Shah, S.F. Rapport, L. Yang, Z. Yingze, N. Britton, J.S. Lee, B.J. McVerry, A. Morris, G.D. Kitsios, McKeesport, PA, p.A4227 420 Streptococcus Pneumoniae Serotype Determine Cardiac Complications During Invasive Pneumococcal Pneumonia/ F. Sanz, L.A. Ruiz Iturriaga, M.M. García Clemente, P.P. España Yandiola, L. Serrano Fernández, A. Uranga Echeverria, J. Herrero Huertas, E. Fernández Fabrellas, Valencia, Spain, p.A4228 421 Cardiovascular Events and 1-Year Mortality in Pneumococcal Community- Acquired Pneumonia (CAP) Compared to Non-Pneumococcal CAP/ H. Saikumar, A. Anzueto, M.I. Restrepo, San Antonio, TX, p.A4230 422 The 2017 Epidemic Pulmonary Plague in Madagascar/ J. Ratomaharo, R. Andriamihaja, L. Razafindrakoto, R. Rakotoarivelo, M. Randria, Athis-Mons, France, p.A4231 423 Clinical Use of Inhaled Bacteriophages to Treat Multi-Drug Resistant Pseudomonas Aeruginosa/ J.L. Koff, B.K. Chan, G.L. Stanley, J.H. Geer, C. Grun, B. Kazmerciak, P.E. Turner, New Haven, CT, p.A7381 BASIC • CLINICAL RAPID: RAPID ABSTRACT POSTER DISCUSSION SESSION B110 MYCOBACTERIAL HOST DEFENSE AND PATHOGENESIS 2:15 p.m. - 4:15 p.m. KBHCCD Ballroom A Four (Level 2) Abstract Summaries 2:15-2:45 Viewing/Discussion 2:45-4:15 Chairing: M. Divangahi, PhD, Montreal, Canada N.W. Schluger, MD, New York, NY K.N. Olivier, MD, MPH, Bethesda, MD 301 Non-Resident Macrophages Are Recruited into the Airways and Modify Host Defenses in Human Recall Responses to Mycobacterium Tuberculosis/ R.F. Silver, T.L. Bonfield, S. O’Leary, J.M. Keane, C.N. Correia, T.J. Hall, D.E. MacHugh, M. Cartwright, M. Cameron, J.R. Jarvela, Cleveland, OH, p.A4232 302 Mycobacterium Tuberculosis Promotes Autophagy in THP-1 Macrophages via Nrf2/ Y. Zhang, F. Fang, F. Wu, J. Lv, T. Wang, Z. Qian, H. Wang, Bengbu, China, p.A4233 ATS 2019 • Dallas, TX 216 MONDAY • MAY 20