ATS 2019 Virtual Final Program

606 Carbonic Anhydrase IX Has a Critical Role in Lung Endothelium Metabolism and Migration/ M. Onanyan, I. Garrison, R. White, M. Crook, E.R. Swenson, T. Stevens, J.Y. Lee, Mobile, AL, p.A4195 607 Genetic Variants in Xanthine Dehydrogenase in Systemic Sclerosis-Related Pulmonary Arterial Hypertension/ C. Simpson, S.C. Mathai, T.M. Kolb, L. Gao, P.M. Hassoun, R.L. Damico, Baltimore, MD, p.A4196 608 Purine Nucleoside Phosphorylase Inhibition Attenuates the Metabolic Syndrome and Associated Pulmonary Hypertension and Right Ventricular Dysfunction/ S.P. Tofovic, J. Hu, E. Jackson, Pittsburgh, PA, p.A4197 609 Metabolomic Signatures of Exercise-Induced Pulmonary Hypertension Suggest It Physiologically Precedes Overt Pulmonary Hypertension/ J. Sanders, Y. Han, D.M. Systrom, A.B. Waxman, Boston, MA, p.A4198 610 Estrogen Imbalance in Patients with Pulmonary Arterial Hypertension: Profiling Metabolites Using LC-MS/MS/ N. Denver, N.Z.M. Homer, N.W. Morrell, R. Andrew, M.R. MacLean, Glasgow, United Kingdom, p.A4199 611 Obesity Modifies Pulmonary Hypertension and Heart Disease in a Large Animal Model/ G.M. Krafsur, K. Jennings, R.D. Brown, T. Holt, D. Gould, S. Riddle, F. Garry, R.M. Enns, M. Thomas, K.R. Stenmark, Aurora, CO, p.A4200 612 Fibroblast Generated Extracellular Vesicles Induces Metabolic Reprogramming in Bone Marrow Derived Macrophages/ S. Kumar, R. Balalsubramaniyan, M. Floren, S. Riddle, H. Zhang, M. Li, M. Frid, K. Hansen, K.R. Stenmark, Aurora, CO, p.A4201 613 Multi-Modal Short Chain Fatty Acid, Butyrate, Is Therapeutic in Hypoxic Pulmonary Hypertension/ E.V. Gerasimovskaya, D. Strassheim, V. Karoor, T. Sullivan, P. Paucek, A. Kovacs-Kasa, A.D. Verin, K.R. Stenmark, Aurora, CO, p.A4202 614 Role of Paxillin and Paxillin Tyrosine Phosphorylation in LPS-Induced Mitochondrial Reactive Oxygen Species Generation and Mitochondrial Dynamics in Lung Endothelial Cells/ P. Fu, J.R. Jacobson, A. Crews, J.G.N. Garcia, V. Natarajan, Chicago, IL, p.A4203 615 Effects of Schistosoma Mansoni and HIV-1 Co-Exposure on Pulmonary Vascular Pathology/ D. Morales Cano, G. Mondejar Parreño, S. Medrano Garcia, B. Barreira, M. Callejo, S. Esquivel Ruiz, R. Kumar, D. Kosanovic, A. Mathie, E. Fernández Malavé, B.B. Graham, R.T. Schermuly, L. Moreno, F. Pérez Vizcaíno, A. Cogolludo, G.S. Butrous, Madrid, Spain, p.A4204 616 Inhibition of Monoamine Oxidase-A Reduces Pulmonary Vascular Remodeling in Experimentally Induced Pulmonary Arterial Hypertension/ X. Sun, E. Peters, I. Schalij, S. Andersen, D. da Silva Goncalves Bos, A. Vonk Noordegraaf, F. De Man, W. van der Laarse, H.J. Bogaard, Amsterdam, Netherlands, p.A4205 617 HIV-Tat and Methamphetamine (METH) Promote Pulmonary Endothelial Cell Apoptosis Through Synergistic Induction of Oxidative Stress: Implications in HIV and METH Induced PAH/ E. Shamskhou, L. Varghese, M. Orcholski, K. Yuan, J. Fessel, N. Dhillon, V. De Jesus Perez, Palo Alto, CA, p.A4206 618 New Insights on Macrophage Function in Pulmonary Hypertension Gained from Comparative Transcriptomics and Metabolomics/ M. Li, S. Riddle, S. Kumar, A. D’Alessandro, D. Champagne, H. Zhang, A. Laux, B.A. McKeon, M. Frid, R.D. Brown, C.-J. Hu, K.R. Stenmark, Aurora, CO, p.A4207 619 Utilizing Precision-Cut Lung Slices to Study the Pulmonary Arterial Smooth Muscle Contractility in a Mouse Model of Pulmonary Vascular Disease/ Y. Bai, G. Li, L.M. Yung, J. Cohen, P.B. Yu, X. Ai, Boston, MA, p.A4208 620 Spermine Promotes Pulmonary Vascular Remodeling and Its Inhibition Ameliorates Pulmonary Arterial Hypertension/ Y.-Y. He, Y. Yan, J.-H. Zhao, Z. Wang, H.-D. Zhang, J.-W. Chen, S.-S. Guo, J. Ye, Y. Yan, J.-L. Zhang, Y. Wang, S.-Y. Zhang, X. Zhang, Z.-C. Jing, Beijing, China, p.A7380 CLINICAL RAPID: RAPID ABSTRACT POSTER DISCUSSION SESSION B109 WHAT’S NEW WITH CLINICAL LUNG INFECTIONS AND PNEUMONIA? 2:15 p.m. - 4:15 p.m. KBHCCD Arena (Level 2) Abstract Summaries 2:15-2:45 Viewing/Discussion 2:45-4:15 Chairing: B.E. Jones, MD, MSc, Salt Lake City, UT G.W. Waterer, MBBS, MBA, PhD, Perth, Australia M.I. Restrepo, MD, MSc, PhD, San Antonio, TX 401 The Clinical Value of a New Molecular Point-of-Care Testing in Hospitalized Lower Respiratory Tract Infection Patients: A Randomized Controlled Study/ S. Duan, X. Gu, G. Fan, Y. Wang, D. Yu, H. Li, F. Zhou, Z. Xiong, B. Lu, G.F. Zhu, B. Cao, Beijing, China, p.A4209 402 Refinement of Estimates of Mortality Risk Using the Radiologic Severity Index in Hematologic Malignancy Patients with Respiratory Syncytial Virus Infection/ A. Sheshadri, M. Karimipour, E. Vakil, L. Bashoura, M. Godoy, D. Shah, D.E. Ost, R.F. Chemaly, S.A. Faiz, Houston, TX, p.A4210 403 Severe and Prolonged Lymphopenia Are Associated with Poor Outcome in Patients with Postoperative Pneumonia/ Y. Murakami, Y. Shindo, M. Sano, J. Okumura, T. Sakakibara, H. Kobayashi, N. Thabet, T. Yagi, Y. Hasegawa, Nagoya, Japan, p.A4211 404 Disease Severity and Clinical Outcomes of Community Acquired Pneumonia Caused by Non-Influenza Respiratory Viruses: A Multicenter Prospective Registry Study from CAP-China Network/ F. Zhou, Y. Wang, Y. Liu, X. Liu, L. Gu, X. Zhang, Z. Pu, G. Yang, B. Liu, Q. Mie, B. Xue, J. Feng, Q. Guo, C. Wang, B. Cao, Beijing, China, p.A4212 405 Viral Pneumonia Is an Independent Risk Factor for Pulmonary Fibrosis: Results of Large-Scale Longitudinal Population-Level Data/ A. Shojaee, N. Kaminski, J.M. Siner, Y. Aryan, X. Yan, C. Dela Cruz, New Haven, CT, p.A4213 ATS 2019 • Dallas, TX MONDAY • MAY 20 215 MONDAY AFTERNOON