ATS 2019 Virtual Final Program

707 Comparative Effects of JUUL, eCig, and Cigarette Smoke on Wound Repair in Alcohol-Exposed Bronchial Epithelial Cells/ T.A. Wyatt, J.M. DeVasure, C. Ochoa, J.C. Woodard, D.L. Knoell, K.L. Bailey, Omaha, NE, p.A4175 708 What’s Your Flavour? Effects of E-cigarette Coil Temperature on Flavour Dependent Reductions of Phagocytosis of Bacteria and Apoptotic Airway Cells/ M. Ween, R. Hamon, H. Jersmann, P.N. Reynolds, S. Hodge, Adelaide, Australia, p.A4176 709 Airway Epithelial Progenitor Cell Dysfunction After Flavoring-Induced Vapor Exposure/ M.D. McGraw, S.-Y. Kim, C. Reed, E. Hernady, I. Rahman, T.J. Mariani, J.N. Finkelstein, Rochester, NY, p.A4177 710 Does Dual Use of Electronic Cigarettes and Conventional Cigarettes Confer a Pulmonary Health Advantage? A Baseline and 12 Month Prospective Cohort Analysis/ W. Bringgold, K. Berg, S. Smith, M. Piper, D. Jorenby, Madison, WI, p.A4178 711 E-Cigarette Use Protects Against Sterile Inflammation in a Mouse Model of Ventilator-Induced Lung Injury/ A. Moshensky, J. Shin, J. Olay, A. Jahan, C.M. Bojanowski, M. Hepokoski, L.E. Crotty Alexander, La Jolla, CA, p.A4179 712 E-Cigarette Vaping/Aerosols: Safe Go-To Alternative to Cigarettes?/ G. Grunig, N. Durmus, S. Pehlivan, J. Zelikoff, New York, NY, p.A4180 713 E-cigarettes Rapidly and Profoundly Affect the Transcriptome of Primary Human Bronchial Epithelial Cells/ A. Altraja, K. Kilk, M. Mitt, S. Altraja, Tartu, Estonia, p.A4181 714 Inhalation of JUUL Aerosols and Flavor Choice Adversely Affects Inflammatory and Metabolic States/ L.E. Crotty Alexander, S.A. Vitorino, A. Moshensky, J. Shin, J. Chien, J. Olay, S. Nilaad, A. Jahan, Y. Chen, I. Advani, C.M. Bojanowski, E.C. Breen, San Diego, CA, p.A4182 715 Nasal Inflammation Is Maintained in Cigarette Smokers Who Switch to E-cigarettes/ M. Kim, N. Baumlin, J.S. Dennis, P. Whitney, A.M. Guerrero-Cignarella, M. Campos, C. Aguiar, S. Paredes-Aller, A. Schmid, E.S. Mendes, M.A. Salathe, Kansas City, KS, p.A4183 716 E-Cigarette Exposed Female Mice Exhibit a Greater Decrement in Exercise Tolerance than Male Mice/ S. Vitorino, A. Lucas, T. Taka, L.E. Crotty Alexander, E.C. Breen, La Jolla, CA, p.A4184 717 Electronic Cigarettes Increase Intracellular Replication of Mycobacterium Abscessus in an In Vitro Lung Model/ A. Korukonda, C. Zhang, L. Rodriguez, A.M. Guerrero, M.A. Campos, G.E. Holt, N. Fregien, G.E. Conner, M. Mirsaeidi, Miami, FL, p.A4185 718 JUUL e-Cigarette and Vape Pen Flavors Impose Oxidative Stress and Inflammatory Responses in Lung Epithelial Cells and Macrophages/ I. Rahman, T. Lamb, T. Muthumalage, Rochester, NY, p.A4186 719 Harm Perceptions of Tobacco/Nicotine Products and Child Exposure: Differences Between Non-Users, Cigarette-Exclusive, and Electronic Cigarette-Exclusive Users/ A.P. Tackett, E.M. Stevens, J.J. Hale, E. Turner, D.A. Fedele, T.L. Wagener, Oklahoma City, OK, p.A4187 720 E-Liquid with Nicotine Causes Mucociliary Dysfunction Via TRPA1 Receptors in a Novel Large Animal Model of Exposure/ N. Baumlin, M. Kim, S. Chung, P. Whitney, J.R. Sabater, W.M. Abraham, M. Salathe, Kansas City, KS, p.A4188 721 E-cigarette Aerosol Stimulates Changes in Structural Proteins of the Lung/ J.E. Bozier, D. Xenaki, B. Oliver, Glebe, Australia, p.A4189 BASIC • TRANSLATIONAL POSTER DISCUSSION SESSION B108 UNDER PRESSURE: THE ROLE OF CELLULAR STRESS IN PULMONARY VASCULAR REMODELING 2:15 p.m. - 4:15 p.m. KBHCCD Ballroom D Three (Level 3) Poster Viewing 2:15-3:00 Discussion 3:00-4:15 Chairing: R. Paulin, PhD, Quebec, Canada M.R. MacLean, PhD, Glasgow, United Kingdom R. Rafikov, PhD, Tucson, AZ 601 High Resolution Microscopy Reveals That Transcription-Associated Oxidative Base Damage Partitions into Active Chromatin Domains in Hypoxic Endothelial Cells/ J. Knighten, R.C. Dolcelli, M. Patel, C.M. Francis, J. Andrews, G. Daly, V.M. Pastukh, R.J. Langley, M.N. Gillespie, Mobile, AL, p.A4190 602 Rapid Redistribution of Oxidative Base Damage in DNA Regulatory Sequences Accompanies Transcriptional Modulation by Hypoxia in the Human Endothelial Cell Genome/ G. Daly, C.M. Francis, V.M. Pastukh, D. Absher, R.J. Langley, M.N. Gillespie, Mobile, AL, p.A4191 603 Inducing Oxidative DNA Damage Overload by Inhibiting the 8oxoguanine Hydrolase MTH1 to Kill Pulmonary Artery Smooth Muscle Cells: A New Therapeutic Strategy in Pulmonary Arterial Hypertension/ G. Vitry, R. Paradis, V. Nadeau, E. Tremblay, S. Provencher, O. Boucherat, S. Bonnet, R. Paulin, Quebec, Canada, p.A4192 604 Transcriptional and Posttranscriptional Mechanisms Contribute to Hypoxia-Induced PINK1 Loss and Mitophagy Derangements in Proliferating Pulmonary Artery Smooth Muscle Cells/ D.E. Green, T. Murphy, C.M. Hart, Atlanta, GA, p.A4193 605 Mitochondrial ROS-Induced Ca2+ Influx Via TRPV4 and Mitochondrial Structure/Function in Microvascular Endothelial Cells Isolated from the Sugen/Hypoxia Model of Pulmonary Arterial Hypertension (PAH)/ K. Suresh, L. Servinsky, H. Jiang, Z. Bigham, J. Zaldumbide, J. Huetsch, C.R. Kliment, M. Acoba, S. Claypool, M. Damarla, L.A. Shimoda, Baltimore, MD, p.A4194 ATS 2019 • Dallas, TX 214 MONDAY • MAY 20