ATS 2019 Virtual Final Program

BASIC • TRANSLATIONAL MINI SYMPOSIUM B96 COMPLEX CELL BEHAVIORS IN PULMONARY FIBROSIS 2:15 p.m. - 4:15 p.m. KBHCCD Room D220/D227 (Level 2) Chairing: D.W.H. Riches, PhD, Denver, CO K.E. Black, MD, Boston, MA C.E. Barkauskas, MD, Durham, NC Oral Presentations 2:15 Whole Lung Single Cell RNAseq Reveals a Unique IPF-Specific Epithelial Cell Population/ J.C. Schupp, T. Adams, N. Neumark, S. Poli De Frias, F. Ahangari, N. Omote, M. Chioccioli, N. Xylourgidis, G. DeIuliis, S. Chu, X. Yan, I.O. Rosas, N. Kaminski, New Haven, CT, p.A4017 2:30 Archetype Analysis Reveals Distinct Disease-Specific Archetypes of Fibroblast and Myofibroblast Co-Occurring Within the IPF Lung/ T. Adams, J. Schupp, N. Neumark, S. Poli De Frias, F. Ahangari, G. DeIuliis, S. Chu, M.S.B. Raredon, X. Yan, I.O. Rosas, N. Kaminski, New Haven, CT, p.A4018 2:45 Beneficial Interstitial Matrix Fibroblasts Are Lost with Age, a New Perspective on Idiopathic Pulmonary Fibrosis/ A.-K.T. Perl, J. Gokey, J. Snowball, J. Green, Y. Xu, Cincinnati, OH, p.A4019 3:00 The Pulmonary Endothelium Plays a Critical Role in the Fibrotic Response to Lung Injury Through S1PR1 and ROCK Mediated Cytoskeletal Rearrangements/ R.S. Knipe, J.J. Spinney, E. Abe, C.K. Probst, A. Franklin, J.W. Griffith, J.K. Liao, J.R. McCarthy, B.S. Shea, B.D. Medoff, Boston, MA, p.A4020 3:15 The Resolution of Pulmonary Fibrosis Is Dependent Upon Matrix Metalloproteinase-9 Expression/ E.F. Redente, B.P. Black, B.L. Edelman, D.W.H. Riches, Denver, CO, p.A4021 3:30 Pluripotent Stem Cells to Unravel the Role of Alveolar Type 2 Epithelial Cells in the Pathogenesis of Pulmonary Fibrosis/ K.-D. Alysandratos, J.-C. Jean, S.J. Russo, S. Mulugeta, K. Wynne, S. Phanse, A. Emili, M.F. Beers, D.N. Kotton, Boston, MA, p.A4022 3:45 Quantification of Integrin avb6in Fibrotic Interstitial Lung Disease with a Cystine Knot PET Tracer. A First in Human Study/ J.J. Mooney, R. Kimura, H.H. Guo, T. Desai, A. Otte, S. Turner, G. Jacobson, S. Srinivas, S. Gambhir, Stanford, CA, p.A4023 4:00 Bcl-2 Overexpression in Fibroblasts Promotes Persistent Fibrosis in a Normally Resolving Model of Pulmonary Fibrosis/ R. Gaurav, B.P. Black, B.L. Edelman, E.F. Redente, D.W.H. Riches, Denver, CO, p.A4024 BASIC • BEHAVIORAL MINI SYMPOS I UM B97 SRN: UPPER AIRWAY PATHOPHYSIOLOGY AND TREATMENT IN SLEEP DISORDERED BREATHING 2:15 p.m. - 4:15 p.m. KBHCCD Room C147/C148/C154 (Level 1) Chairing: A. Malhotra, MD, ATSF, La Jolla, CA B.J. Petrof, MD, Montreal, Canada M. Teodorescu, MD, MS, Madison, WI Oral Presentations 2:15 Phenotypic Predictors of Long-Term Upper Airway Neurostimulation Responsiveness in the ADHERE International Cohort/ R. Mehra, K. Doghramji, R.J. Schwab, P.J. Strollo, K.P. Strohl, Cleveland, OH, p.A4025 2:30 Effects of Natural Rostral Fluid Redistributions Induced by Gravity on the Severity of Obstructive Sleep Apnea/ Y. Huang, S. Wang, H. Zhang, X. Huang, C. Wang, H. Lin, H. Xu, C. Ji, Beijing, China, p.A4026 2:45 Lower Loop Gain and Reduced Ventilatory Response to Arousal Are Associated with Mandibular Advancement Device Treatment Efficacy/ S. Op de Beeck, S.A. Sands, A. Azarbarzin, M. Willemen, J. Verbraecken, M. Braem, D.A. Wellman, O.M. Vanderveken, Wilrijk (Antwerpen), Belgium, p.A4027 3:00 Effects of the Combination of Atomoxetine and Oxybutynin on Obstructive Sleep Apnea Phenotypic Traits/ L. Taranto Montemurro, L. Messineo, A. Azarbarzin, D. Vena, L. Hess, N. Calianese, R. Salant, D.P. White, D.A. Wellman, S.A. Sands, Boston, MA, p.A4028 3:15 Effect of Fluticasone Propionate on Tongue Muscles Properties/ C. Setzke, O. Broytman, J. Russell, N. Connor, M. Teodorescu, Madison, WI, p.A4029 3:30 Mechanisms to Restore Airway Patency Post Collapse in Obstructive Sleep Apnoea/ L. Gell, K. Reynolds, Y.-M. Luo, D. McEvoy, P. Catcheside, Adelaide, Australia, p.A4030 3:45 Effect of Sleep on Upper Airway Dynamics in Obese Children with Obstructive Sleep Apnea/ S. Agrawal, S. Sin, S. Lee, J. Udupa, D. Wootton, M. Wagshul, R. Arens, Bronx, NY, p.A4031 BEHAVIORAL MINI SYMPOSIUM B98 TARGETING THE IMMUNE SYSTEM IN LUNG CANCER PROGRESSION 2:15 p.m. - 4:15 p.m. KBHCCD Ballroom A One (Level 2) Chairing: A.M. Houghton, MD, Seattle, WA V. Keshamouni, PhD, Ann Arbor, MI ATS 2019 • Dallas, TX 206 MONDAY • MAY 20