ATS 2019 Virtual Final Program

Featured Speaker 2:15 Featured Speaker/ S.M. Dubinett, Los Angeles, CA Oral Presentations 2:30 Eosinophils Promote Metastasis of Circulating Cancer Cells to Inflammatory Sites Through Ccl6 Secretion in Mice/ F. Li, X. Du, C. Zhang, C. Zhu, W. Li, Z. Chen, S. Ying, H. Shen, Hangzhou, China, p.A4032 2:45 Immune Alterations Associated with DiseaseProgression in Bronchial Premalignant Lesions/ C. Merenstein, S. Mazzilli, J.D. Campbell, K. Krysan, C. Moy, C. Perdomo, M. Schaffer, G. Liu, S. Zhang, H. Liu, J. Vick, S.S. Dhillon, S. Platero, S.M. Dubinett, C.S. Stevenson, M. Reid, M.E. Lenburg, A. Spira, J. Beane, Boston, MA, p.A4033 3:00 Intratumoral CCL21-Gene Modified Dendritic Cells (CCL21-DC) Combined with Checkpoint Blockade in Murine Models of Non-Small Cell Lung Cancer (NSCLC) with Varying Mutational Load/ R. Salehi-Rad, R. Li, B. Liu, R. Lim, L. Tran, S. Ong, Z.L. Huang, M. Paul, K. Krysan, D. Shackelford, S.M. Dubinett, Los Angeles, CA, p.A4034 3:15 Axl Receptor Tyrosine Kinase Up-Regulates Ligands for Programmed Cell Death 1 in Lung Adenocarcinoma/ Y. Tsukita, N. Fujino, E. Miyauchi, K. Itakura, Y. Kyogoku, M. Yamada, T. Okazaki, H. Sugiura, M. Ichinose, Sendai, Japan, p.A4035 3:30 Use of SPD-CD40L to Recruit Immune Cells to the Tumor Microenvironment/ G.E. Holt, G.W. Stone, Miami, FL, p.A4036 3:45 Microenvironmental Th9- and Th17- Lymphocytes Induce Epithelial Mesenchymal Transition and Metastatic Spreading in Lung Cancer/ R. Savai, Y. Salazar, X. Zheng, D. Brunn, H. Raifer, V. Dennis, H. Winter, A. Weigert, F. Grimminger, W. Seeger, S.S. Pullamsetti, M. Huber, Bad Nauheim, Germany, p.A4037 4:00 Lower Airway Dysbiosis Leads to A Pro-Tumor Inflammatory State and Worsens Non-Small Cell Lung Cancer Prognosis in a Preclinical Model/ J. Tsay, B. Wu, I. Sulaiman, P. Meyn, Y. Li, T.-A. Yie, K. Yie, E. Olsen, M. El-Ashmawy, S. Ma, L. Perez, A. Gonzalez, B. Franca, A. Heguy, H. Pass, K.-K. Wong, T. Papagiannakopoulos, D.H. Sterman, L.N. Segal, New York, NY, p.A4038 BASIC • TRANSLATIONAL RAPID: RAPID ABSTRACT POSTER DISCUSSION SESSION B101 ADVANCES IN COPD PATHOGENESIS 2:15 p.m. - 4:15 p.m. KBHCCD Room C141/C143/C149 (Level 1) Abstract Summaries 2:15-2:45 Viewing/Discussion 2:45-4:15 Chairing: S. Christenson, MD, MS, San Francisco, CA I.D. Pavord, MD, Oxford, United Kingdom M.H. Cho, MPH, MD, Boston, MA 201 Antagonism of Sphingosine-1-Phosphate Receptors Improves Macrophage Phagocytosis of Bacteria in COPD Patients/ P. Fenwick, A. Taylor, J. Ujetz, P.J. Barnes, L. Donnelly, London, United Kingdom, p.A4039 202 Altered Alveolar Macrophage Expression of Axl and Mertk in COPD: SPIROMICS Immunophenotyping Sub-Study/ M. Bates, J.P. Brown, C.M. Freeman, V.R. Stolberg, M. Kady, Y. Wang, S. Murray, N.E. Alexis, I. Barjaktarevic, R.G. Barr, E.R. Bleecker, R.P. Bowler, S. Christenson, A.P. Comellas, C.B. Cooper, D. Couper, G.J. Criner, C.M. Doerschuk, M.K. Han, N.N. Hansel, A.T. Hastie, E.A. Hoffman, Y.J. Huang, R.J. Kaner, J.A. Krishnan, F.J. Martinez, D.A. Meyers, W.K. O’Neal, R. Paine, S.P. Peters, N. Putcha, J.M. Wells, N. Wilson, P. Woodruff, J.L. Curtis, Ann Arbor, MI, p.A4040 203 Chronic Obstructive Pulmonary Disease (COPD) Shifts Alveolar Macrophage Polarization Towards Senescence Phenotype/ K. Akata, K. Yamasaki, F.S. Leitao Filho, H. Takiguchi, Y. Sun, J.M. Leung, P.S.F. Man, D.D. Sin, S.F. Van Eeden, Vancouver, Canada, p.A4041 204 Upregulation of Leukocyte Immunoglobulin-Like Receptor B4 on Interstitial Macrophages in COPD/ A. Mitsune, M. Yamada, N. Fujino, M. Yoshiya, K. Itakura, H. Sugiura, S. Endo, T. Takai, M. Ichinose, Sendai, Japan, p.A4042 205 The Impact of Different Inhaled Corticosteroids, Bronchodilators and Azithromycin on Lung Microbiota in the Murine Model of Emphysema/ Y.-F. Chen, H.-H. Hou, S.-L. Cheng, H.-C. Wang, C.-J. Yu, Yun-Lin, Taiwan, p.A4043 206 Association of Platelet Count with All-Cause Mortality and Risk of Cardiovascular and Respiratory Morbidity in Stable COPD/ A. Fawzy, J.A. Anderson, N. Cowans, C. Crim, R.A. Wise, J.C. Yates, N.N. Hansel, Baltimore, MD, p.A4044 207 Upregulation of Antiviral Biomarkers in Sputum Cells Following Administration of Inhaled Interferon Beta to Patients with COPD/ P. Monk, S. Reynolds, K. Lunn, R. Beegan, J. Roberts, V. Tear, Southampton, United Kingdom, p.A4045 208 Association Between Inflammation Pathways and Phenotypes of Pulmonary Dysfunction Using Cluster Analysis in HIV-Infected and Uninfected Individuals/ S. Qin, L. Vodovotz, S.M. Nouraie, M. Fitzpatrick, C.J. Kessinger, L. Kingsley, K.A. Crothers, L. Huang, A.M. Morris, Pittsburgh, PA, p.A4046 209 Immunoglobulin E as a Biomarker of Asthma-COPD Overlap/ C.P. Hersh, A. Mirtar, N. Putcha, S. Zarei, Boston, MA, p.A4047 210 Sputum IgA Autoantibodies Predict the Chronic Obstructive Pulmonary Disease Exacerbations/ F. Wang, Z. Liang, Y. Yang, M. Jiang, W. Shi, Y. Li, R. Chen, Guangzhou, China, p.A4048 211 Aberrant Complement Activation In Alpha-1 Antitrypsin Deficiency/ L. Fee, M.E. O’Brien, T.P. Carroll, D.M. Dunlea, K. McQuillan, M. Molloy, O.J. McElvaney, E.P. Reeves, N.G. McElvaney, Dublin, Ireland, p.A4049 212 Ultrafine Particles in Airways: A Novel Marker of Inflammation and Chronic Obstructive Pulmonary Disease (COPD) Exacerbation Risk/ E. Fireman Klein, Y. Adir, A. Krencel, E.M. Fireman, R. Peri, A. Kessel, Haifa, Israel, p.A4050 ATS 2019 • Dallas, TX MONDAY • MAY 20 207 MONDAY AFTERNOON