ATS 2019 Virtual Final Program

P799 Glutathione-s-Transferase p Promotes Interleukin-1ß Induced Pulmonary Inflammation in Association with S-Glutathionylation of the Glycolysis Regulator, Pyruvate Kinase M2/ C. van de Wetering, A. Manuel, X. Qian, R. Aboushousha, S.B. Chia, C. Erickson, J. Bates, C. Irvin, A. Van Der Velden, A. Van Der Vliet, N. Reynaert, E. Wouters, Y. Janssen-Heininger, Burlington, VT, p.A3831 P800 Transcriptional Clustering of Asthmatics Identifies IL18R1 Expression as a Risk Factor for Severe Disease/ M. Camiolo, H. Trejo Bittar, A. Ray, S.E. Wenzel, Pittsburgh, PA, p.A3832 P801 Obesity Enhances DUOX1-Mediated Innate Allergen Responses and Type 2 Inflammation in Allergic Asthma/ A. Van Der Vliet, M. Hristova, A. Habibovic, Y.M.W. Janssen-Heininger, C.G. Irvin, M. Geiszt, V. Anathy, M.E. Poynter, A.E. Dixon, Burlington, VT, p.A3833 BASIC • CLINICAL • TRANSLATIONAL THEMATIC POSTER SESSION B63 ANIMAL MODELS OF COPD 9:15 a.m. - 4:15 p.m. KBHCCD Area D (Hall F, Level 2) Viewing: Posters will be on display for entire session. Discussion: 11:15-12:00: authors will be present for individual discussion 12:00-1:00: authors will be present for discussion with assigned facilitators. Facilitator : D.A. Deshpande, PhD, Philadelphia, PA P583 Establishment of a New Model of Chronic Obstructive Pulmonary Disease/ Z. Wang, J. Shu, J.X.J. Yuan, J. Wang, Tucson, AZ, p.A3834 P584 The Role of Cholinergic Anti-Inflammatory System on the Effects of Exercise Training in an Experimental Murine Model of Pulmonary Emphysema/ N. Souza, F. Santana, E. Batista, R. de Laia, T. Escrobat, T. Castro, F. Lopes, M.A. Prado, A.C. Toledo, I. Tibério, V. Prado, C. Prado, C.R. Olivo, Santos, Brazil, p.A3835 P585 Roles of Reactive Persulfide Species in the Lung of Elastase-Induced Emphysema Model/ H. Sano, H. Sugiura, T. Numakura, S. Yamanaka, M. Yamada, N. Fujino, T. Ichikawa, R. Tanaka, Y. Kyogoku, T. Akaike, M. Ichinose, Sendai, Japan, p.A3836 P586 The Role of Myeloid Cell Type-Specific Inducible Nitric Oxide Synthase in Chronic Obstructive Pulmonary Disease/ M. Gredic, S. Kraut, C.Y. Wu, S. Hadzic, O. Pak, M. Brosien, W. Seeger, M. Seimetz, N. Weissmann, Giessen, Germany, p.A3837 P587 Roles of Bronchoconstriction in Progression of Emphysema in Murine Models/ Y. Hamakawa, A. Sato, A. Watanabe, T. Mizutani, K. Uemasu, N. Tanabe, S. Sato, T. Hirai, Kyoto, Japan, p.A3838 P588 Anti-Jagged1 Antibody AMG 430 Reduces Airway Mucus in Mouse Models of Obstructive Pulmonary Disease/ J.E. Phillips, S. Davis, J. Werner, T. Buber, L. Feng, B.D. Bennett, X. Zhang, Thousand Oaks, CA, p.A3839 Facilitator : P. Kohli, MD, Boston, MA P589 Th17/Treg Imbalance in Chronic Obstructive Pulmonary Disease (COPD) Development: The Role of Suppressors of Cytokine Signaling (SOCS) and Signal Transducers and Activators of Transcription (STAT) Proteins/ L.E.D.F. Silva, J.D. Lourenço, K.R. Silva, J.B. Kohler, F.P.R. Santana, A.R. Moreira, D.A.B. Cervilha, C.M. Prado, A.P.P. Velosa, R.P. Vieira, J.T. Ito, F.D.Q.S. Lopes, Sao Paulo, Brazil, p.A3840 P590 Ion Transport and Mucus Transport Defects Are Improved by a Novel CFTR Potentiator in the COPD Ferret/ N. Kaza, V. Lin, D. Stanford, S. Byzek, L. Tang, S.V. Raju, S.M. Rowe, Birmingham, AL, p.A3841 P591 Inhalational Delivery of Induced Pluripotent Stem Cell (iPSC) Secretome on Canine Post-Pneumonectomy Compensation/ D.M. Dane, K. Cao, K.H. Kernstine, A. Gazdhar, T.K. Geiser, C.C. Hsia, Dallas, TX, p.A3842 P592 In Search of Alpha-Klotho Protein Expression in the Lung/ K. Cao, J. Zhang, P. Johanne, O. Moe, C.C. Hsia, Dallas, TX, p.A3843 P593 Imaging Airway Disease in a Ferret Model of COPD/ D. Stanford, J. LaFontaine, S. Byzek, H. Nath, S. Bodduluri, S.P. Bhatt, S.V. Raju, S.M. Rowe, Birmingham, AL, p.A3844 BASIC • CLINICAL • TRANSLATIONAL THEMATIC POSTER SESSION B64 COPD: MECHANISM AND TREATMENT 9:15 a.m. - 4:15 p.m. KBHCCD Area D (Hall F, Level 2) Viewing: Posters will be on display for entire session. Discussion: 11:15-12:00: authors will be present for individual discussion 12:00-1:00: authors will be present for discussion with assigned facilitators. Facilitator : A. Tam, PhD, Vancouver, Canada P595 Cholinergic Receptor Nicotinic Alpha 5 Expression in the Airways of Patients with Chronic Obstructive Pulmonary Disease/ A. Tam, M. Obeidat, T.-L. Hackett, D.R. Dorscheid, G. Singhera, J.C. Hogg, D.D. Sin, Vancouver, Canada, p.A3845 P596 RPL554 (Dual PDE3/4 Enzyme Inhibitor): Baseline Airway Reversibility Impacts Immediate Bronchodilation, in Contrast to Progressive Symptom Improvement/ D. Singh, B.T. Maurer, F.J. Martinez, T. Bengtsson, Manchester, United Kingdom, p.A3846 P597 Accelerated ATP Hydrolysis in Airway Surface Liquid (ASL) Provides a Mechanism for Mucus Dehydration in Chronic Bronchitis/ W.H. Anderson, M. Quibrera, W.K. O’Neal, M.B. Drummond, N.E. Alexis, I. Barjaktarevic, D. Couper, L. Bateman, R. Paine, R.J. Kaner, J.L. Curtis, P. Woodruff, M.K. Han, F.J. Martinez, R.G. Barr, N.N. Hansel, E.R. Bleecker, E.A. Hoffman, V.E. Ortega, C.M. Doerschuk, V. Kim, M.T. Dransfield, S.P. Bhatt, R.P. Bowler, G. Criner, C.B. Cooper, R.E. Kanner, R.C. Boucher, E. Lazarowski, Chapel Hill, NC, p.A3847 ATS 2019 • Dallas, TX MONDAY • MAY 20 183 MONDAY MORNING