ATS 2019 Virtual Final Program

P774 Cell Type-Specific Epigenomic and Transcriptomic Responses to Asthma-Associated Cytokines/ L. Bonser, W. Eckalbar, K.D. Koh, L. Zlock, S. Bolourchi, A. Joo, C.P. Nguyen, B. Antalek, W. Finkbeiner, N.R. Bhakta, P. Woodruff, N. Ahituv, D.J. Erle, San Francisco, CA, p.A3806 P775 sST2/IL-33 Balance Regulates Neutrophil-Related Cytokine Release in the Human Airways/ M. Watanabe, M. Sada, K. Nakamoto, T. Inui, Y. Ogawa, M. Tamura, T. Yokoyama, K. Honda, T. Saraya, D. Kurai, H. Ishii, H. Takizawa, Tokyo, Japan, p.A3807 P776 Il-5R Expression on Airway Neutrophils in Treatment-Refractory Asthma/ C. Welch, M.G. Lawrence, M.S. Spano, J.W. Steinke, T. Braciale, W.G. Teague, L. Borish, Charlottesville, VA, p.A3808 Facilitator : K. Cahill, MD, Nashville, TN P777 Parkin Deficiency Enhances Mitochondrial DNA Release Promotes Airway Inflammation/ K.G. Dimasuay, D.E. Winnica, F. Holguin, R. Gottlieb, H.W. Chu, Denver, CO, p.A3809 P778 Identification and Characterization of an IL-13-Inducible SPDEF Enhancer in Human Airway Secretory Cells/ K.D. Koh, L.R. Bonser, W.L. Eckalbar, X. Zeng, L.T. Zlock, J.L. Pollack, W.E. Finkbeiner, N. Ahituv, D.J. Erle, San Francisco, CA, p.A3810 P779 Novel Adenosinergic Pathway in the Lungs/ M.S. Kannan, A.G.P. Guedes, R.A. Graeff, R. Quintana, E. Wendt-Hornicle, C.F. Baldo, St. Paul, MN, p.A3811 P780 Differential Tumor Necrosis Factor Ligand and Receptor Expression on Monocyte Subsets in Blood and Sputum/ N.M. Niessen, J.L. Simpson, K.J. Baines, P.G. Gibson, M. Fricker, Newcastle, Australia, p.A3812 P781 YKL-40 Facilitates Airway Remodeling in Asthma Via Activating FAK and MAPK Signaling Pathway/ H. Tang, Y. Sun, B. Liu, Shanghai, China, p.A3813 P782 Over Expression of Cathepsin B and Its Induction by Ethanol in Asthmatic Vs Non-Asthmatic Bronchial Epithelial Cells and Related AMPK a and ER Stress Signaling/ L. Kaphalia, M.P. Srinivasan, B.S. Kaphalia, W.J. Calhoun, Galveston, TX, p.A3814 P783 Effect of Corticosteroids on Metabolic Gene Expression in Airway Smooth Muscle Cells/ J. Tsang, B. Xu, J. Xie, K.F. Chung, C. Michaeloudes, P.K. Bhavsar, London, United Kingdom, p.A3815 P784 TSLP Is the Predominant Innate Type 2 Cytokine Produced by the Human Infant Airway Epithelium/ K. Salka, M.A. Arroyo Morr, S. Naime, E. Chorvinsky, D.K. Pillai, G. Perez, G.R. Nino, Washington, DC, p.A3816 P785 Sphingolipid Deficiency Alters Rhinovirus Infection of Airway Epithelial Cells and Macrophages/ E. Wasserman, S. Worgall, New York, NY, p.A3817 Facilitator : C.J. Britto-Leon, MD, ATSF, New Haven, CT P786 Establishing a Model to Study How Usage of Beta-2 Agonists Can Modify Human Airway Epithelial Responses to Asthma Exacerbation Stimuli/ M. Evangelista, B. Saef, S. Sajuthi, C. Rios, J.L. Everman, M.T. Montgomery, M. Cromie, C. Eng, V. Medina, S. Oh, J.R. Rodriguez-Santana, E.G. Burchard, M.A. Seibold, Denver, CO, p.A3818 P787 Tissue Factor Is Increased in a Mouse Model of Allergic Asthma/ T.P. Cremona, J.W.W. Baek, J. Mitchel, N. Mackman, J.-A. Park, Boston, MA, p.A3819 P788 The Role of Secreted Frizzled Related Protein-1 in Alveolar Macrophage Differentiation in Asthma/ N. Rai, E. Arteaga-Solis, J. Sonett, J.M. D’Armiento, New York, NY, p.A3820 P789 Metagenomic Analysis of Sputum in the U-Biopred Cohort Shows Reduced Diversity in Asthmatics/ A. Versi, S. Bates, J.H. Riley, S. Pavlidis, R. Djukanovic, P.J. Sterk, A. Bansal, A.R. Sousa, D. Shaw, S. Fowler, S.S. Wagers, G. Roberts, C. Auffray, S.-E.K. Dahlen, F. Baribaud, K.F. Chung, I.M. Adcock, P. Howarth, London, United Kingdom, p.A3821 P790 Primary Airway Smooth Muscle Cells from Subjects with and Without Asthma Reveal Distinct Differences in Contractile, Epigenetic, and Transcriptional Responses to the Asthma-Promoting Cytokines IL-13 + IL-17/ E. Thompson, Q. Dang, B. Mitchell-Handley, K. Rajendran, S. Ram-Mohan, J. Solway, R. Krishnan, C. Ober, Chicago, IL, p.A3822 P791 Sex-Dependent Effect of TRPM8 rs10166942 Polymorphism on Cold-Induced Airway Hyperresponsiveness in Asthma/ D. Naumov, O. Kotova, D. Gassan, A. Prikhodko, V. Kolosov, Blagoveshchensk, Russian Federation, p.A3823 P792 Mir-375 Attenuated Innate Immune Response in Bronchial Epithelial Cell Through Modulate of Nf- k B Pathway/ K. Takagi, K. Machida, T. Matsuyama, K. Sakaue, K. Kondo, M. Yamakuchi, T. Hashiguchi, H. Inoue, Kagoshima-shi, Japan, p.A3824 P793 Histone Deacetylase Activation in Bronchial Epithelium of Children with Severe Therapy Resistant Asthma/ S. Naime, K. Salka, E. Chorvinsky, M.A. Arroyo Morr, G.R. Nino, D.K. Pillai, Washington, DC, p.A3825 Facilitator : A. Van Der Vliet, PhD, Burlington, VT P794 Fevipiprant, a Selective Prostaglandin D 2 Receptor 2 Antagonist, Potently Inhibits Chemotaxis and Cytokine Production by Tc2 cells (type-2 CD8 + lymphocytes)/ L. Xue, W. Chen, J. Luo, M.M. Chizari, R. Borst, S. Kazani, V.J. Erpenbeck, D. Sandham, Oxford, United Kingdom, p.A3826 P795 Treatment with Liponucleotides Attenuates DRA-Induced Asthma in Mice/ I.C. Davis, A.M. Nelson, L.M. Joseph, L.E. Rosas, Columbus, OH, p.A3827 P796 New Continuous Nebulizer Shortens Treatment Times for Patients Requiring Bronchodilation Therapy/ M. Nagel, J. Suggett, C. Doyle, D.P. Coppolo, London, Canada, p.A3828 P797 Up-Regulation of Paraoxonase 2 in Human Bronchial Epithelial Cells/ D.E. Winnica, S. Sharma, L.G. Que, S. Ye, V.L. Smith, M.H. Cruse, N. Perez, F. Holguin, Aurora, CO, p.A3829 P798 Analysis of the Mechanism of Exercise Induced Bronchoconstriction in Murine Model/ H. Ueno, T. Koya, K. Tsukioka, H. Takeuchi, M. Hayashi, T. Hasegawa, E. Suzuki, T. Kikuchi, Niigata, Japan, p.A3830 ATS 2019 • Dallas, TX 182 MONDAY • MAY 20