ATS 2019 Virtual Final Program

P598 Nrf2 Polymorphisms Contributes to Emphysema in Healthy Smokers/ A. Sugitani, K. Asai, A. Miyamoto, K. Kojima, H. Kubo, Y. Kyoumoto, T. Kawamoto, S. Yoshida, A. Okamoto, K. Satou, K. Yamada, N. Ijiri, T. Watanabe, Y. Tochino, H. Kanazawa, T. Kimura, S. Fukumoto, K. Hirata, T. Kawaguchi, Osaka, Japan, p.A3848 P599 The Rare PI Z Variant Associates with Bronchiectasis in Non-Hispanic White At-Risk Current and Ex-Smokers and COPD Subjects from SPIROMICS/ F. Genese, J.D. Newell, W.K. O’Neal, C.R. Marion, X. Li, G.A. Hawkins, C.E. Brehm, I. Barjaktarevic, R.G. Barr, C.B. Cooper, D. Couper, M.K. Han, N.N. Hansel, R.E. Kanner, E.C. Kleerup, F.J. Martinez, R. Paine, P. Woodruff, E.A. Hoffman, S.P. Peters, D.A. Meyers, E.R. Bleecker, V.E. Ortega, Winston-Salem, NC, p.A3849 P600 Quantitative Ultra-High Resolution CT Assessment of Airway Morphology in Smokers with and Without Chronic Obstructive Pulmonary Disease/ H. Shima, N. Tanabe, T. Oguma, T. Kubo, A. Sato, S. Sato, T. Hirai, Kyoto, Japan, p.A3850 P601 Strain Measurement on 4-Dimensional Dynamic-Ventilation CT: Quantitative Analysis of Pulmonary Motion Heterogeneity in COPD/ T. Yamashiro, Y. Xu, H. Moriya, M. Tsubakimoto, Y. Nagatani, S. Murayama, Okinawa, Japan, p.A3851 P602 Automatically Measuring Airway Inner Volume Assessed by Computed Tomography Imaging in Patients with COPD: Relationships Between Airway Inner Volume and Airflow Limitation/ A. Oguma, K. Shimizu, M. Suzuki, S. Konno, H. Makita, M. Nishimura, Sapporo, Japan, p.A3852 Facilitator : B.M. Smith, MD, MS, Montreal, Canada P603 Role of Sildenafil in Lowering Lung Inflammation During Smoking Cessation: A Multispectral CT Assessment of Lung Anatomy and Perfused Blood Volume/ Y. Liu, A. Motahari, A.P. Comellas, D.W. Kaczka, A.K. Gerke, J. Wilson, E.A. Hoffman, Iowa City, IA, p.A3853 P604 Sildenafil-Based Reduction in Sub-Acinar Pulmonary Perfusion Heterogeneity Does Not Alter Acinar-Scale Histograms of V/Q Matching Derived from Dual Energy CT/ A. Motahari, Y. Liu, A.P. Comellas, D.W. Kaczka, A.K. Gerke, J.S. Wilson, E.A. Hoffman, Iowa City, IA, p.A3854 P605 Correlation of SPECT-Based Ventilation Patterns with CT Image-Derived COPD Clusters/ F. Li, B. Haghighi, J. Choi, S. Choi, E.A. Hoffman, A.P. Comellas, M.M. Graham, C.-L. Lin, Iowa City, IA, p.A3855 P606 The Relationship Between the Modified Medical Research Council (mMRC) Dyspnea Scale and Airway Structure Assessed by Three-Dimensional CT in Patients with Chronic Obstructive Pulmonary Disease/ H. Yasui, N. Inui, M. Karayama, K. Mori, H. Hozumi, Y. Suzuki, K. Furuhashi, N. Enomoto, T. Fujisawa, Y. Nakamura, T. Suda, Hamamatsu, Japan, p.A3856 P607 A Case of Vanishing Lung Syndrome: A Rare Form of Bullous Emphysema/ M. Yasin, V. van Berkel, Louisville, KY, p.A3857 P608 Assessment of Health Status of COPD Patient Using Dynamic Digital Radiography(DDR): Correlation Between COPD Assessment Test (CAT) Score and Change Ratio of Lung Area During Deep Breathing/ N. Ohkura, K. Kasahara, M. Tamura, I. Matsumoto, J. Hara, S. Sanada, R. Tanaka, Kanazawa, Japan, p.A3858 P609 The Effect of Pulmonary Function, Power and Maximum Power Output on Dyspnoea in a Real-World Cohort/ I. Satia, R.P. Cusack, M. Matsuoka, X. Yanquing, P. O’Byrne, K.J. Killian, Hamilton, Canada, p.A3859 P610 The Effects of Intermittent Breathing of 100% Oxygen on Ventilation- Perfusion Heterogeneity as Measured by Multiple Inert Gas Elimination Technique in Subjects with Chronic Obstructive Pulmonary Disease/ A.R. Elliott, V. Tedjasaputra, A.S. Kizhakke Puliyakote, B. Pazar, H. Wagner, R.C. Sa, J.E. Orr, G.K. Prisk, P.D. Wagner, S.R. Hopkins, La Jolla, CA, p.A3860 Facilitator : P. Chitano, PhD, Vancouver, Canada P611 Usefulness of Correlation in Peak Flow and Forced Expiratory Volume in One Second in the Diagnosis and Severity Assessment in Patients with Chronic Obstructive Pulmonary Disease/ N. Mesiha, K. Nangrani, A. Patel, M. Alipour, V. Vasudevan, Brooklyn, NY, p.A3861 P612 Forced Vital Capacity Reversibility Post-Bronchodilator Is Associated with Dynamic Hyperinflation on Stage 1 Cardiopulmonary Exercise Testing in Patients with COPD/ A. Kouri, M.B. Stanbrook, Toronto, Canada, p.A3862 P613 Evaluation of DLCO, FEV1 and Hematocrit as Possible Predictors for Home Oxygen Therapy/ A.H. Almadani, M. Abduljalil, R. O’Donnell, Dublin, Ireland, p.A3863 P614 Characterization of Lung Function in Coronary Heart Disease and Chronic Obstructive Pulmonary Disease - Going Beyond Spirometry/ F. Trinkmann, J. Schaefer, J. Gawlitza, J.D. Michels, T. Sieburg, K. Stach, C. Doesch, M. Borggrefe, I. Akin, Mannheim, Germany, p.A3864 P615 Discovery of Subclinical Airflow Limitation Detectable by Hyperpolarized Xenon-129 MRI Imaging in Healthy Subjects with Normal Spirometry/ C.Y. Tan, L.A. Myc, K. Qing, N.J. Tustison, J.F. Horta Coelho Mata, Z. Lin, Y. Huang, J.Y. Shin, T.A. Altes, J. Mugler, Y.M. Shim, Charlottesville, VA, p.A3865 P616 D of Inner Cross-Sectional Area of Airway Branches in COPD Patients/ D. Kinose, E. Ogawa, Y. Matsuo, W. Shigemori, Y. Uchida, K. Fukunaga, H. Nakagawa, M. Yamaguchi, T. Nagao, Y. Nakano, Otsu, Japan, p.A3866 P617 Characteristics of Airflow and Particle Deposition in Airway Variants Among Smokers and Non-Smokers/ C. Zou, J. Choi, B. Haghighi, S. Choi, E.A. Hoffman, A.P. Comellas, R.G. Barr, B.M. Smith, C.-L. Lin, Iowa City, IA, p.A3867 P618 Dose-Ranging Effects of Glycopyrronium Bromide (GB) Delivered Via a Pressurized Metered Dose-Inhaler (pMDI) on Lung Function in Subjects with Chronic Obstructive Pulmonary Disease (COPD): The GLIMMER Study/ J. Pearle, E.M. Kerwin, L. Delacruz, C. Beaudot, M. Edwards, G. Georges, Fullerton, CA, p.A3868 ATS 2019 • Dallas, TX 184 MONDAY • MAY 20