ATS 2019 Virtual Final Program

P577 The Pharmacogenomics of Inhaled Corticosteroids and Lung Function Decline in COPD Patients/ M. Obeidat, A. Faiz, X. Li, M. Van Den Berge, N.N. Hansel, P. Joubert, K. Hao, C.-A. Brandsma, N. Rafaels, R. Mathias, I. Ruczinski, T. Beaty, K. Barnes, P. Man, P.D. Pare, D.D. Sin, Vancouver, Canada, p.A3786 P578 RNA-Sequencing Analysis of Human Plasma-Derived Extracellular Vesicles as Potential Circulating Biomarkers in Chronic Obstructive Pulmonary Disease/ I.K. Sundar, D. Li, I. Rahman, Rochester, NY, p.A3787 P579 The Impact of Corticosteroids on Chronic Obstructive Pulmonary Disease Lung Macrophage Phenotype and Function/ A.J. Higham, A. Baba Dikwa, T. Scott, J. Li, S. Lea, D. Singh, Manchester, United Kingdom, p.A3788 P580 TNF- a Reduced C/EBP-a Expression by Up-Regulating Microrna101 in Airway Smooth Muscle Cells of COPD Patients/ L. Fang, X. Wang, Q. Sun, P. Khan, M. Tamm, D. Stolz, M. Roth, Basel, Switzerland, p.A3789 P581 The Tyrosine Kinase c-Src Down Regulates Glutathione Peroxidase-1 Levels in the Airway Epithelium by Dysregulating Its mRNA/ A.J. Dabo, W. Ezegbunam, A. Wyman, I. Garcia-Arcos, P. Geraghty, R.F. Foronjy, Brooklyn, NY, p.A3790 BASIC • TRANSLATIONAL THEMATIC POSTER SESSION B62 ASTHMA MECHANISMS 9:15 a.m. - 4:15 p.m. KBHCCD Area E (Hall F, Level 2) Viewing: Posters will be on display for entire session. Discussion: 11:15-12:00: authors will be present for individual discussion 12:00-1:00: authors will be present for discussion with assigned facilitators. Facilitator : G.L. Chupp, MD, New Haven, CT P759 A Novel Mechanism of Gasdermin-Dependent IL-33 Secretion Links the Most Replicated Asthma Associated Genetic Loci: IL33, GSDMB, and IL1RL1/ O. Bernard, M.E. Lachowicz-Scroggins, L. Sharp, S.P. Sajuthi, M. Seibold, E.D. Gordon, San Francisco, CA, p.A3791 P760 Apolipoprotein E Induces CXCL5 Secretion by Asthmatic Airway Epithelial Cells via TLR4-Dependent Activation of TAK1/NF-kB/MAP3K8/JNK Signaling Pathways/ O. Kalchiem-Dekel, X. Yao, D.M. Figueroa, E.M. Gordon, M. Kaler, A.V. Barochia, L. Poching, Y. Li, F. Seifuddin, M. Pirooznia, S.J. Levine, Bethesda, MD, p.A3792 P761 Associations Between Arginine Metabolism Related Metabolites and Clinical Outcomes-A Longitudinal Metabolomic Study/ S.-Y. Liao, A. Linderholm, M. Showalter, L. Franzi, O. Fiehn, A.A. Zeki, N.J. Kenyon, Sacramento, CA, p.A3793 P762 Development of an Epithelial-Derived Airflow Obstruction Gene Expression Signature Using Systems Approaches/ S. Roberts, M. Richardson, T.S.C. Hinks, P. Howarth, P. Bradding, S.E. Wenzel, S. Siddiqui, Leicester, United Kingdom, p.A3794 P763 Genomic Regulation of Cell-Type Specification in the Airway Epithelium/ W. Eckalbar, L.R. Bonser, K.D. Koh, L. Zlock, J. Pollack, S. Bolourchi, C. Nguyen, N.R. Bhakta, W. Finkbeiner, P. Woodruff, N. Ahituv, D.J. Erle, San Francisco, CA, p.A3795 P764 Genomic Interrogation of Asthma and Asthma-Drug Response in Bronchial Smooth Muscle Cells/ W. Eckalbar, O. Elor, M.A. Seibold, E.G. Burchard, N. Ahituv, San Francisco, CA, p.A3796 P765 Exposure to Ambient Particles Amplifies the Eotaxin-1 Release from Alternatively Activated Macrophages in Allergen-Sensitized Mice/ M. Huang, J. Zhang, Z. Chen, Nanjing, China, p.A3797 P766 The Receptor for Advanced Glycation Endproducts Is a Critical Mediator of Type 2 Cytokine Signal Transduction in the Lungs/ T.N. Perkins, E. Oczypok, R. Dutz, M. Myerburg, T.D. Oury, Pittsburgh, PA, p.A3798 P767 Identification of Sub-Sets of Viral Bronchiolitis Based on Clinical Phenotyping, Quantitative Lung Imaging, Respiratory Outcomes and Airway Immune Responses/ M.A. Arroyo Morr, K. Salka, G.F. Perez, C.E. Rodriguez-Martinez, J.A. Castro-Rodriguez, G.R. Nino, Washington, DC, p.A3799 Facilitator : N.K. Sandbo, MD, Madison, WI P768 Functional Translation of IL33 Locus Polymorphisms Into Altered Epithelial Cell Function Underlying Asthma/ M. Ketelaar, M.A. Portelli, F.N. Dijk, A. Faiz, N. Shrine, J. Hankinson, S. Bhaker, A.P. Henry, C.K. Billington, D. Shaw, S.R. Johnson, A.V. Benest, Z.E.K. Pogson, A. Fogarty, T.M. McKeever, A. Singapuri, L. Heaney, A. Mansur, R. Gaudhuri, N.C. Thomson, J.W. Holloway, G.A. Lockett, P.H. Howarth, R. Niven, A. Simpson, M.D. Tobin, D.S. Postma, I.P. Hall, L.V. Wain, C.E. Brightling, M. Obeidat, D.D. Sin, M. van den Berge, G.H. Koppelman, I. Sayers, M.C. Nawijn, Groningen, Netherlands, p.A3800 P769 Glucocorticoids Repress Genes Induced by TNF-Alpha and IL-13 by Reducing Chromatin Accessibility at Enhancers/ A. Gupta, V. Kadiyala, T. Song, F.S. Gally, S. Sasse, A.N. Gerber, Aurora, CO, p.A3801 P770 Systemic Immunometabolism in Asthmatics and Biomass or Tobacco Smoke Exposed Chronic Obstructive Pulmonary Disease (COPD) Patients/ A. Agarwal, S. Kadam, A. Brahme, M. Agrawal, K. Apte, G. Narke, S. Madas, S.S. Salvi, Pune, India, p.A3802 P771 The Decrease of Mitochondrial Biogenesis Contributes Airway Epithelial Barrier Dysfunction in Asthma/ T. Saito, T. Ichikawa, N. Fujino, T. Numakura, Y. Sasaki, K. Itakura, M. Yamada, H. Sugiura, M. Ichinose, Sendai City, Japan, p.A3803 P772 Free Fatty Acid Receptor 1 (FFAR1) Agonist GW9508 Attenuates Excitation-Contraction Coupling in Human Airway Smooth Muscle (HASM) Cells/ J. Jude, S. Xu, A. Schwab, N. Karmacharya, G. Cao, W. Jester, R. Panettieri, Jr., New Brunswick, NJ, p.A3804 P773 Genetic Regulation of Airway Remodeling Following Chronic Allergen Exposure in Mice/ L. Donoghue, M. Patterson, K. McFadden, J. Thomas, A. Tovar, S.N. Kelada, Chapel Hill, NC, p.A3805 ATS 2019 • Dallas, TX MONDAY • MAY 20 181 MONDAY MORNING