ATS 2019 Virtual Final Program

P550 The Role of ORMDL3 in Cigarette Smoke-Induced Airway Injury/ R. Chen, S.C. Yeung, M.S. Ip, J.C.W. Mak, Hong Kong, Hong Kong, p.A3759 P551 Modeling PiMZ AATD Hepatocyte Injury Using Patient-Specific Syngeneic iPSCs/ J. Kaserman, C. Villacorta-Martin, D.N. Kotton, A.A. Wilson, Boston, MA, p.A3760 P552 Black Carbon Content in Airway Macrophages Is Associated with Respiratory Symptoms in Former Smokers with COPD/ V. Tejwani, S.-E. Tang, E. Moughames, L. Grammer, K. Romero, H. Woo, N. Putcha, F.R. D’Alessio, N.N. Hansel, Baltimore, MD, p.A3761 P553 Phospholipase A2 Receptor 1 Promotes Lung-Cell Senescence and Emphysema in Obstructive Lung Disease/ D. Beaulieu, A. Attwe, M. Breau, L. Lipskaia, E. Born, E. Marcos, J. Huang, S. Abid, A. Houssaini, B.M. Maitre, N. Vienney, D. Vindrieux, D. Bernard, S. Adnot, Créteil, France, p.A3762 P554 Cellular Senescence in Lung Fibroblasts from COPD Patients Is Associated with Altered Extracellular Matrix Regulation/ R.R. Woldhuis, M. de Vries, W. Timens, M. van den Berge, B. Oliver, I.H. Heijink, C.-A.A. Brandsma, Groningen, Netherlands, p.A3763 Facilitator : I.K. Sundar, BSc, MSc, PhD, Rochester, NY P555 Neutrophil Elastase and Alpha-1-Antitrypsin Binding in Monocyte Derived Microparticles/ P. Consiglio, E. Homsy, S. Das, M.C. Exline, C. McAtee, A. Zachman, M.D. Wewers, A. Sarkar, Columbus, OH, p.A3764 P556 Protein Phosphatase 2A Prevents Cigarette Smoke-Induced Cathepsin S and Loss of Lung Function/ S. Nath, D.F. Doherty, R.F. Foronjy, M. Ohlmeyer, J. Poon, A.J. Dabo, M.A. Salathe, M. Birrell, M. Belvisi, N. Baumlin, M.D. Kim, S. Weldon, C. Taggart, P. Geraghty, Brooklyn, NY, p.A3765 P557 Localization of Interstitial Macrophages in Human Lungs from Cigarette Smokers and Nonsmokers/ P. Hume, S. Gibbings, C.V. Jakubzick, P.M. Henson, W.J. Janssen, Denver, CO, p.A3766 P558 Mechanistic Contribution of Liver Disease Risk Allele Variants to Protein Trafficking in Alpha-1 Antitrypsin Deficiency/ K. Steinberg, P. Akepati, J. Kaserman, A.A. Wilson, Boston, MA, p.A3767 P559 IL-17A-Dependent Lymphoid Neogenesis in COPD Involves RANKL-RANK Expression/ Y. Sun, Beijing, China, p.A3768 P560 Mitochondrial Adenine Nucleotide Translocase Influences Ciliary Function and Airway Homeostasis/ C. Kliment, J. Nguyen, J. Radder, F.C. Sciurba, Y. Zhang, A. Gregory, P.A. Iglesias, V.K. Sidhaye, S.D. Shapiro, D.N. Robinson, Pittsburgh, PA, p.A3769 P561 Chemical Inhibition of S100 Calcium-Binding Protein A9 Signaling Reduces Cigarette Smoke-Induced Loss of Lung Function in Mice/ C.N. Railwah, J. Poon, G. Gupta, S. Nath, A.J. Dabo, R.F. Foronjy, P. Geraghty, Brooklyn, NY, p.A3770 P562 Downregulation of the RNA Binding Protein HuR Correlates with Enhanced Expression of Senescence Markers in COPD Bronchial Epithelial Cells/ A.E. Wyman, A.J. Dabo, W. Ezegbunam, I. Garcia-Arcos, N. Baumlin-Schmid, M.A. Salathe, P. Geraghty, R.F. Foronjy, Brooklyn, NY, p.A3771 P563 Emphysema in Mice Lacking uPARAP/ S. Stephenson, C. Atkinson, C.L. Wilson, L.M. Schnapp, Charleston, SC, p.A3772 Facilitator : A. Noel, PhD, MSc, BSc, Baton Rouge, LA P564 Alpha-1 Antitryspin Inhibition of MMP-13: Implications in Acute Exacerbations of COPD/ M.P. Goldklang, K.N. Stearns, V. Anguiano, R.M. Reed, P.T. Elkington, J.M. D’Armiento, New York, NY, p.A3773 P565 Extracellular Vesicle Pathways Are Required for Airway Epithelial IL-33 Secretion in COPD/ J. Alexander-Brett, E. Katz, D. Steinberg, D.E. Byers, K.L. Bailey, D. Katafiasz, M.J. Holtzman, S.L. Brody, St. Louis, MO, p.A3774 P566 Protective Effect of Neuropeptide Y Against Elastase-Induced Emphysema/ A. Taniguchi, N. Oda, D. Morichika, S. Senoo, U. Fujii, J. Itano, A. Kanehiro, K. Kiura, Y. Maeda, N. Miyahara, Okayama, Japan, p.A3775 P567 Misfolded Alpha-1 Antitrypsin Protein Produced by Alveolar Epithelial Cells Generated from Patient-Derived Induced Pluripotent Stem Cells Is Absent After CRISPR/Cas9 Gene Editing/ K.J. Hurley, A. Jacob, J. Kaserman, F.J. Hawkins, A.A. Wilson, D.N. Kotton, Dublin, Ireland, p.A3776 P568 Developing Oxysterol Inhibitors as a Novel Therapeutic Target for iBALT Driven Chronic Pulmonary Diseases/ B. Srivastava, T.M. Conlon, E. Mitula, R.S.J. Sarker, A.O. Yildirim, Munich, Germany, p.A3777 P569 Mechanisms of Emphysematous Changes in Lung of Mice Deficient in Leukotriene C4 Synthase/ Y. Ishii, T. McGovern, U. Fujii, S. Farahnak, N. Khazaei, J.G. Martin, Montreal, Canada, p.A3778 P570 Dynein Has Defective Activity in COPD Macrophage Phagocytosis/ K.L. Anders, K.B.R. Belchamber, D.C.A. Gaboriau, P.J. Barnes, L.E. Donnelly, London, United Kingdom, p.A3779 P571 Budesonide Suppresses Proinflammatory Responses in Chronic Obstructive Pulmonary Disease by Inhibiting the Expression of MicroRNA-17/ Y. Chen, P.S. Thomas, R.K. Kumar, C. Herbert, Sydney, Australia, p.A3780 P572 Resolvin D1 Blocks the Beneficial Effects of Mesenchymal Stromal Cells in a Murine Model of Emphysema/ F.F. Cruz, L. Costa Agra, N.D.N. Rocha, B. Lourenço Diaz, C. Bandeira de Melo, P.L. Silva, P.R.M. Rocco, Rio de Janeiro, Brazil, p.A3781 Facilitator : N.V. Kolliputi, PhD, Tampa, FL P573 Preclinical Efficacy of a GPR4 Antagonist in a Murine Emphysema-Exacerbation Model/ A. Addante, F. Wunder, L. Dietz, M. Brechmann, M. Koch, J.I. Borissoff, M. Lizé, Wuppertal, Germany, p.A3782 P574 The PD-1 Immune Checkpoint Regulates COPD-Like Inflammation in Mice/ C. Beisswenger, F. Ritzmann, G. Vella, A. Lis, C. Herr, R. Bals, Homburg, Germany, p.A3783 P575 Genome-Wide Association Study of Longitudinal Change in Quantitative Emphysema/ W. Kim, M.H. Cho, D.A. Lynch, E.K. Silverman, T.H. Beaty, Baltimore, MD, p.A3784 P576 Noxa in Airway Epithelia Inhibits NF-?B Activation and the Development of Cigarette Smoke-induced Emphysema/ Y.A. Mebratu, J.T. Jones, D. Tassew, T.J. Mariani, Y. Tesfaigzi, Albuquerque, NM, p.A3785 ATS 2019 • Dallas, TX 180 MONDAY • MAY 20