ATS 2019 Virtual Final Program

P682 Common MicroRNA-mediated Pathobiological Changes in Bronchial Epithelial Cells of Both Asthma and Chronic Obstructive Pulmonary Diseases/ M.-J. Tsai, W.-A. Chang, Y.-C. Tsai, Y.-L. Hsu, P.-L. Kuo, C.-C. Sheu, Kaohsiung, Taiwan, p.A2920 P683 Genome Wide Interaction Study of Bronchodilator Response in Individuals with Asthma Shows Potential Effect Modification of CDH22 Genetic Variants by Age/ J. Sordillo, S.M. Lutz, M. McGeachie, R.S. Kelly, A. Dahlin, K.G. Tantisira, J.A. Lasky-Su, A.C. Wu, Boston, MA, p.A2921 P684 Gene Expression Analysis of Activated Human ILC2s Based on “Single Cell Secretion Activity Analysis System (LCI-S)”/ M. Kuwae, M. Matsusaka, M. Yamagishi, S. Koga, K. Miyata, T. Kamatani, Y. Tanaka, Y. Araki, T. Kikawada, K. Moro, S. Moro, Y. Shirasaki, K. Fukunaga, Tokyo, Japan, p.A2922 Facilitator : J.G. Ledford, PhD, Tucson, AZ P685 Genetic Effects of ORMDL3/GSDMB on Asthma Are Modified by the GSDMC Genotype at Chromosome 8/ H. Kitazawa, H. Masuko, J. Kanazawa, R. Shigemasa, K. Hyodo, Y. Yatagai, H. Iijima, T. Naito, T. Saito, T. Hirota, M. Tamari, T. Sakamoto, N. Hizawa, Tsukuba, Japan, p.A2923 P686 Relationship Between Mitochondrial Copy Number and Asthma Status/ S. Xiao, M. Cocco, E. White, M. Yang, H. Gui, A. Levin, A. Mak, P. Sleiman, S. Hochstadt, K. Whitehouse, D. Rynkowski, F.D. Gilliland, W.J. Gauderman, R. Kumar, F.D. Martinez, D.E. Lanfear, H. Hakonarson, E.G. Burchard, L.K. Williams, Detroit, MI, p.A2924 P687 Genome-Wide Interaction Study Reveals Age-Dependent Determinants of Response to Inhaled Corticosteroids in Asthma Patients/ A. Dahlin, J. Sordillo, M. McGeachie, R.S. Kelly, K.G. Tantisira, J.A. Lasky-Su, A.C. Wu, Boston, MA, p.A2925 P688 Fine-Mapping of Bronchodilator Response Admixture Mapping Peak to Identify Causal Drug Response Genetic Variants/ M. Daya, E. Ampleford, J.G. Zein, M. Castro, S.C. Erzurum, J.V. Fahy, E. Israel, N.N. Jarjour, B.D. Levy, S.E. Wenzel, G.A. Hawkins, X. Li, K. Barnes, S.P. Peters, W.C. Moore, E.R. Bleecker, D.A. Meyers, V.E. Ortega, Aurora, CO, p.A2926 P689 Blood RNA Profiling with a Portable Sequencer to Identity Asthma Endotypes/ P. Michel, X. Yan, G.L. Chupp, J.L. Gomez, New Haven, CT, p.A2927 P690 CASTER: Cross-Sectional Asthma STEroid Response Measurement/ M. McGeachie, A. Kho, S.T. Weiss, K.G. Tantisira, Boston, MA, p.A2928 P691 MicroRNA miR-223 Is Associated with Lung Function Impairment and TH17 Inflammation in Asthma/ J.L. Gomez, A. Chen, X. Yan, L.E. Cohn, G.L. Chupp, New Haven, CT, p.A2929 P692 A cis-eQTL Allele Lowering Gene Expression of CHL3L1 Is Associated with Late-Onset Adult Asthma in Japanese/ R. Shigemasa, J. Kanazawa, H. Kitazawa, H. Masuko, K. Hyodo, Y. Yatagai, T. Sakamoto, Y. Kaneko, H. Iijima, T. Naito, T. Saito, E. Noguchi, S. Konno, M. Nishimura, T. Hirota, M. Tamari, N. Hizawa, Tsukuba, Japan, p.A2930 P693 Human Lung MicroRNA-1 Is Regulated by IL-13 and Correlates with Tissue Eosinophilia in Airway Inflammation/ B. Hu, A. Korde, L.E. Cohn, J.-H. Chu, S. Takyar, New Haven, CT, p.A2931 BASIC • CLINICAL • TRANSLATIONAL THEMATIC POSTER SESSION B33 ASTHMA: MECHANISMS OF DISEASE II 9:15 a.m. - 4:15 p.m. KBHCCD Area E (Hall F, Level 2) Viewing: Posters will be on display for entire session. Discussion: 11:15-12:00: authors will be present for individual discussion 12:00-1:00: authors will be present for discussion with assigned facilitators. Facilitator : C. Lloyd, PhD, London, United Kingdom P695 Adverse Effects on Bone in Rats Exposed to Chronic Intermittent Hypoxia and Allergen-Induced Asthma/ G. Wojdyla, T. Crenshaw, K. Hansen, O. Broytman, M. Teodorescu, Madison, WI, p.A2932 P696 Tiotropium Bromide Suppresses Airway Inflammation in Mouse Model of Asthma/ T. Matsuyama, K. Machida, K. Sakaue, A. Tanoue, K. Takagi, I. Higashimoto, H. Inoue, Kagoshima, Japan, p.A2933 P697 TRPA1-Deficient Mice Were Suppressed Airway Inflammation in a Papain Induced Model/ T. Matsuyama, K. Machida, K. Sakaue, K. Takagi, H. Inoue, Kagoshima, Japan, p.A2934 P698 Cavin-1 Regulated IL-33 Release by Living Cells in Mouse Asthma/ Y. Ni, J. Hao, W. Du, Y. Yu, T. Chen, G. Shi, B. Li, Shanghai, China, p.A2935 P699 Early and Intermittent IL-4Ra Blockade Prevents H1N1-Mediated Weight Loss in a Mouse Model of Allergic Asthma/ K. Shahangian, R. Chen, D.A. Ngan, Y. Oh, D.A. Knight, D.R. Dorscheid, T.-L. Hackett, K.M. McNagny, M. Niikura, P. Man, J.A. Hirota, D.D. Sin, Vancouver, Canada, p.A2936 P700 IL-4Ra Blockade as a Treatment in Established H1N1 Infection in a Mouse Model of Allergic Asthma/ K. Shahangian, R. Chen, D.A. Ngan, Y. Oh, D.A. Knight, D.R. Dorscheid, T.-L. Hackett, K.M. McNagny, M. Niikura, P. Man, J.A. Hirota, D.D. Sin, Vancouver, Canada, p.A2937 P701 Effect of Aminophylline on Mouse Bone Marrow-Derived Eosinophils In Vitro/ F.-P. Wang, Y.-Q. Fan, T. Liu, G. Wang, Y. Pu, S.-Y. Li, H. Mao, Chengdu, China, p.A2938 P702 Angiotensin-Converting Enzyme 2 (ACE2) Activator Attenuates House Dust Mite-Induced Allergic Airway Inflammation in Mice/ A. Fukuda, S. Maruoka, S. Yamada, Y. Kurosawa, Y. Kozu, Y. Gon, Tokyo, Japan, p.A2939 P703 Preventative Administration of Interleukin-27 (IL-27) Via Tracheal Attenuates Allergic Asthma by Promoting Th1 Differentiation and the Positive Feedback of IL-27 in the Local Microenvironment/ X. Liu, S. Li, J. Jin, T. Zhu, K. Xu, Y. Zeng, R. Mao, X. Wang, Z. Chen, Qingdao, China, p.A2940 P704 Classic Interleukin-6 Signaling Qualitatively Regulates Airway Inflammation but Not Methacholine Hyperresponsiveness in a Model of Neutrophilic Severe Allergic Asthma/ K. Menson, M.M. Mank, L.F. Reed, J.L. Ather, M.E. Poynter, Burlington, VT, p.A2941 ATS 2019 • Dallas, TX 146 MONDAY • MAY 20