ATS 2019 Virtual Final Program

P657 Ambient PM 2.5 Enhances the Pulmonary Allergic Immune Response via DUOX1 to Activate Allergen-Induced IL-33 Secretion and Type 2 Immune Effects/ J. Zhang, C.B. Fulgar, X. Sun, W. Li, L. Cui, A. Castaneda, K. Bein, Q. Zhang, S. Xu, K.E. Pinkerton, Hubei, China, p.A2895 P658 Suppressive Effect of a TLR7 Agonist in IL-33-induced Eosinophilic Airway Inflammation/ S. Okuzumi, J. Miyata, T. Mochimaru, S. Kagawa, M. Matsusaka, T. Tanosaki, R. Watanabe, M. Kuwae, M. Nishiura, S. Ueda, K. Fukunaga, Tokyo, Japan, p.A2896 P659 Effective Treatment of Experimental Asthma by Lung Restricted Inhibition of Janus Kinase 1/ H. Rardin, X. Wu, I. Peng, C. Rinderknecht Eller, Y. Kwon, E. Suto, P. Bir Kohli, G. Cain, M. Briggs, S. Addo, G. Salmon, S. Ubhayakar, G. Deshmukh, S. Shahidi-Latham, C. Quiason-Huynh, J. Liu, N. Ray, S. Goodacre, A. Johnson, B. McKenzie, W. Lee, M. Zak, J. Kenny, N. Ghilardi, South San Francisco, CA, p.A2897 P660 Hyaluronan Synthase 2 (HAS2) Mediates Airway Inflammation and Remodeling in Chronic Ovalbumin Model of Asthma/ M. Sherpa, T. Kiwamoto, Y. Tsunoda, K. Yoshida, H. Osawa, M. Nakajima, M. Matsuyama, Y. Matsuno, Y. Morishima, Y. Ishii, N. Hizawa, Tsukuba, Japan, p.A2898 P661 The Effect of Weight Loss on Bronchial Asthma Model/ N. Yuki, K. Toshiyuki, H. Takashi, U. Hiroshi, K. Yoshizawa, S. Akira, N. Syun, Y. Kimura, H. Masachika, T. Kikuchi, Niigata, Japan, p.A2899 P662 Bone Marrow Derived Dendritic Cell (BMDC) Adoptive Transfer Alleviate Ova-Induced Allergic Airway Inflammation in Asthma Mice/ Z. Chen, K. Xu, N. Wu, Z. Min, Z. Jiang, Shanghai, China, p.A2900 P663 Inhalation Delivery of Type III Interferons Restricts Epithelial-Derived Th2 Inflammation and Pathologic Responses in Allergic Asthma/ H.J. Kim, J.-Y. Ji, Y. Song, J. Won, A. Jo, C.-S. Rhee, Seoul, Korea, Republic of, p.A2901 P664 A Humanized Mouse Model to Study Asthmatic Airway Inflammation Via Human IL-33/IL-13 Axis/ S. Maruoka, S. Yamada, R. Ito, S. Nunomura, S. Toyoshima, Y. Okayama, K. Izuhara, S. Hashimoto, Y. Gon, Tokyo, Japan, p.A2902 Facilitator : J.L. Sturgill, PhD, Lexington, KY P665 Role of Apoptosis Inhibitor of Macrophage (AIM) in Mouse Asthma Model/ M. Matsumoto, H. Kimura, M. Suzuki, S. Konno, Sapporo, Japan, p.A2903 P666 Bronchial Epithelial Cells of Different Ages Regulate Th2 and Th17 Cell Differentiation Through MBD2 Mediating the Level of sICOSL/ Y. Yuan, Q. Zen, X. Xiang, Changsha, China, p.A2904 P667 The Role of Innate Lymphoid Cells (ILCs) in Mice Model of Irritant Induced Asthma/ U. Fujii, Y. Ishii, E. Nakada, N. Khazaei, S. Farahnak, T. McGovern, J.G. Martin, Montreal, Canada, p.A2905 P668 Roles for IRE1 Paralogs and the Unfolded Protein Response in Asthma/ V. Auyeung, N.R. Bhakta, B. Backes, D. Maly, P. Woodruff, D. Sheppard, F. Papa, San Francisco, CA, p.A2906 P669 Pharmacological Characterization of T Cell-Induce Broncho-Constriction/ A. Mori, S. Kouyama, M. Yamaguchi, C. Kumitani, A. Ohtomo-Abe, N. Fujita, M. Iwata, K. Nagayama, K. Ryu, Y. Nakamura, Y. Tomita, Y. Hamada, H. Hayashi1, K. Watai, Y. Kamide, K. Sekiya, Y. Fukutomi, M. Taniguchi, T. Ohtomo, O. Kaminuma, Sagamihara, Japan, p.A2907 P670 A New Compound, Cyn-1324, for Treating with Asthma/ H.-M. Chen, W.-H. Huang, M.-L. Kuo, C.-Y. Kuo, HsinChu, Taiwan, p.A2908 P671 Immunometabolism of Alveolar Macrophages Is Modulated by Beta Agonist Exposure/ N.M. Weathington, H. Wong, K. Chen, S. Shiva, E. Valenzi, M. Camiolo, R.A. Lafyatis, B. Modena, Pittsburgh, PA, p.A2909 P672 Acidic pH-Induced CXCL8 Secretion Through Proton-Sensing Receptor OGR1 in Human Airway Smooth Muscle Cells/ T. Ishizuka, M. Kadowaki, H. Yamada, K. Sato, H. Shigemi, Y. Umeda, M. Morikawa, Y. Waseda, M. Anzai, Y. Kamide, H. Aoki-Saito, T. Hisada, F. Okajima, Eiheiji, Japan, p.A2910 P673 Surfactant Protein A Modulates IL-13 and IL-6 Phosphorylation of STAT3/ M. Conway, D. Francisco, A. Hurbon, J. Gozdz, H.W. Chu, J.G. Ledford, M. Kraft, Tucson, AZ, p.A2911 P674 Soluble 15-Lipoxygenase Type 1 from Rhinovirus-Infected Epithelial Cells Causes Airway Epithelial Injury/ L. Shi, A. Guadarrama, N. Lane, L.C. Denlinger, Madison, WI, p.A2912 Facilitator : J. Griffith, MD, PhD, Boston, MA P675 Expression of Remodeling-Associated Genes by LAD2 Mast Cells Cultured with Uninfected and Rhinovirus-Infected Asthmatic Bronchial Epithelial Cells/ L.M. Rich, K.A. Barrow, M.P. White, S.R. Reeves, T.S. Hallstrand, A.M. Piliponsky, J.S. Debley, Seattle, WA, p.A2913 P676 Effect of Rhinovirus Infection of Asthmatic Bronchial Epithelial Cells on Expression of Airway Remodeling Associated Genes/ L.M. Rich, K.A. Barrow, M.P. White, S.R. Reeves, J.S. Debley, Seattle, WA, p.A2914 P677 Increased B-Cells in the Airways of Patients with Severe Eosinophilic Asthma: A Local Auto-Inflammatory Process/ H.F. Lim, N.S. Tan, M. Mukherjee, S.Y. Lim, C.H. Thiam, W.S.D. Tan, W.S.F. Wong, K. Fink, A. Rouers, P.K. Nair, V. Angeli, Singapore, Singapore, p.A2915 P678 Analysis of Sputum Immune Cell Populations and Their Functional Status in Asthmatics/ E. Stewart, G.L. Chupp, R.R. Montgomery, Q. Liu, J. Estrom, New Haven, CT, p.A2916 P679 A Novel In-Vitro Model to Study Endothelial Dysfunction in Asthma/ P. Rajasekar, A. Knox, R.L. Clifford, Nottingham, United Kingdom, p.A2917 P680 Mechanisms Underlying Corticosteroid Insensitivity Induction by Interleukin-17A in Bronchial Epithelial Cells/ W. Akik, N. Dauletbaev, L.C. Lands, Montreal, Canada, p.A2918 P681 High Expression of NLRP2 in Bronchial Epithelial Cells May Implicate Unique Role in Lung Inflammation/ A. Perryman, W. Rivera-Martin, A.M. Speen, I. Jaspers, Chapel Hill, NC, p.A2919 ATS 2019 • Dallas, TX MONDAY • MAY 20 145 MONDAY MORNING