ATS 2019 Virtual Final Program

BASIC • CLINICAL • TRANSLATIONAL RAPID: RAPID ABSTRACT POSTER DISCUSSION SESSION B28 HOW AIRWAYS MALFUNCTION: NEW CONCEPTS 9:15 a.m. - 11:15 a.m. KBHCCD Ballroom A Four (Level 2) Abstract Summaries 9:15-9:45 Viewing/Discussion 9:45-11:15 Chairing: S.H. Randell, PhD, Chapel Hill, NC V.K. Sidhaye, MD, Baltimore, MD F. Polverino, MD, PhD, Tucson, AZ 301 Association of Small Airway Epithelium Expression of Keratin 6A in COPD Smokers with SNPs in Regions Linked to Lung Cancer/ J. Salit, W.-L. Zuo, Y. Strulovici-Barel, M.J. Thomas, J. Schymeinsky, K. Quast, S. Visvanathan, J.S. Fine, R.G. Crystal, New York, NY, p.A2820 302 IL-36 g is Released from Small Airway Epithelial Cells and Drives Macrophage Inflammation in COPD/ J. Baker, P.S. Fenwick, J. Tilman, P.J. Barnes, L.E. Donnelly, London, United Kingdom, p.A2821 303 Regulation of Connective Tissue Growth Factor (CTGF) Expression Via EGFR-Dependent and Independent Pathways in Small Airway Basal Stem/Progenitor Cells/ H. Zhang, J. Salit, M. Rostami, W.-L. Zuo, M.J. Thomas, J. Schymeinsky, K. Quast, S. Visvanathan, J.S. Fine, J.G. Mezey, R. Crystal, New York, NY, p.A2822 304 High Resolution Evaluation of Human Airway Cell Diversity Towards Understanding the Cellular Composition and Function of the Distal Human Airways/ M.C. Basil, W. Zacharias, J. Katzen, J. Carl, S. Li, M. Morley, J.F. Engelhardt, C. Edward, E.E. Morrisey, Philadelphia, PA, p.A2823 305 Regulation of Protease Activity in Distal Airway Is Critical for Ciliated Cell Regeneration During Chronic Cigarette Smoke Exposure/ K. Uemasu, A. Sato, N. Tanabe, K. Tanimura, K. Hasegawa, Y. Hamakawa, T. Mizutani, S. Sato, S. Muro, T. Hirai, Kyoto, Japan, p.A2824 306 More than a Tight Junction: Crucial Role of Claudin-18 in the Response to Airway Injury/ A. Castaldi, P. Zamani, M. Xie, P. Flodby, A. Allen, W. Pinson-Rose, M. Horie, C. Li, P. Minoo, P. Hor, Y. Ji, H. Shen, B.R. Stripp, B. Zhou, A.L. Ryan, Z. Borok, Los Angeles, CA, p.A2825 307 Arginine Methylation Epigenetically Regulates Airway Epithelial Cell Injury In COPD Pathogenesis/ T.M. Conlon, G. Günes, R.S.J. Sarker, H. Fehrenbach, A.O. Yildirim, Munich, Germany, p.A2826 308 Pou2af1 Is a Novel Regulator of Airway EpithelialCells Differentiation and Response to Fibrotic Injury/ Q. Li, N. Omote, T. Adams, M. Chioccioli, A. Shakya, G. DeIuliis, E. Herzog, D. Tantin, J.D. Herazo-Maya, N. Kaminski, New Haven, CT, p.A2827 309 CRISPR Knockdown of JAG1 in hTERT-Immortalized Normal Human Bronchial Epithelial Cells Decreases Production of MUC5B from Airway Epithelial Organoids/ J.E. Phillips, K.A. Henckels, J. Whoriskey, T. Buber, B.D. Bennett, Thousand Oaks, CA, p.A2828 310 DUOX1-Dependent IL-33 Secretion from the Airway Epithelium Involves Positive Feedback Signaling Through Activation of IL-33R/ST2/ C. Dustin, C. Schiffers, D.E. Heppner, M. Hristova, A. Habibovic, A. Van Der Vliet, Burlington, VT, p.A2829 311 ORMDL3 and Autophagy of the Airway Epithelium: An Important Mechanism Underlying Asthma Pathogenesis?/ Y. Hao, F. Guo, P. Kothari, B.D. Levy, A.X. Zhou, B.A. Raby, Boston, MA, p.A2830 312 An Immortalized Small Airway Basal Cell Line with Airway Region-Associated Diverse Differentiation Capacity/ G. Wang, H. Lou, J. Salit, P.L. Leopold, M.J. Thomas, J. Schymeinsky, K. Quast, S. Visvanathan, J.S. Fine, R.G. Crystal, New York, NY, p.A2831 313 Autophagy Augmentation Alleviates Cigarette Smoke Induced CFTR Dysfunction, Ceramide Accumulation and COPD-Emphysema Pathogenesis/ N. Vij, M. Bodas, G. Pehote, D. Silverberg, E. Gulbins, Baltimore, MD, p.A2832 314 Lef-1 and Sox2 Are Required for Glandular Myoepithelial Stem Cell Expansion After Airway Injury/ C. Jensen-Cody, A. Crooke, T.J. Lynch, P.J. Anderson, J.F. Engelhardt, Iowa City, IA, p.A2833 315 Senescence and Fibrotic Markers Are Induced by Oxidative Stress in Small Airway Fibroblasts from COPD Patients/ C.L. Wrench, J.R. Baker, P.S. Fenwick, L.E. Donnelly, P.J. Barnes, London, United Kingdom, p.A2834 316 Reconstruction of Patient-Specific Distal Airway Regeneration Patterns in COPD/ S.B. Mahjour, K. Gomi, S. Rustam, P. Dolma, J. Krishnan, R. Bareja, Y. Hu, O. Elemento, T. Zhang, J. Xiang, A. Urso, F. D’Ovidio, S.H. Randell, B.W. Richmond, V.V. Polosukhin, T.S. Blackwell, R. Shaykhiev, New York, NY, p.A2835 317 Murine Modeling of Deployment-Related Chronic Bronchiolitis by Conditional Depletion of Airway Club Cells/ J.J. Osterholzer, S. Teitz-Tennenbaum, S.P. Viglianti, A.M. Jomaa, A.-K.T. Perl, Ann Arbor, MI, p.A2836 318 Early Death in SLC26A9-Deficient Mice Is Due to Airway Mucus Obstruction Associated with Epithelial Necrosis and Neutrophilic Inflammation/ J.J. Salomon, P. Millar Buechner, S. Spahn, W. Wagner, M.A. Mall, Heidelberg, Germany, p.A2837 319 Estrogen Receptor ß Knock Out Exacerbates Airway Hyperresponsiveness and Remodeling in a Murine Model of Asthma/ R.S.R. Kalidhindi, N.S. Ambhore, J. Loganathan, C.M. Pabelick, Y.S. Prakash, V. Sathish, Fargo, ND, p.A2838 320 Tet1 Contributes to Allergic Airway Inflammation Through Regulation of Type I Interferon Signaling/ H. Ji, J. Burleson, D. Siniard, X. Chen, M.T. Weirauch, B.P. Ruff, B.B. Eric, G.K. Khurana Hershey, Davis, CA, p.A7366 321 Resistin Pathway as Novel Mechanism of Post-Lung Transplantation Bronchial Stenosis/ D.H. Yu, C. Fan, Q. Lin, L.B. Yarmus, R.A. Johns, Stanford, CA, p.A7367 ATS 2019 • Dallas, TX MONDAY • MAY 20 141 MONDAY MORNING