ATS 2019 Virtual Final Program

BASIC • CLINICAL • TRANSLATIONAL POSTER DISCUSSION SESSION B29 MECHANISMS FOR AIRWAY HYPERRESPONSIVENESS: FROM CELL TO ORGANISM 9:15 a.m. - 11:15 a.m. KBHCCD Ballroom D Four (Level 3) Poster Viewing 9:15-10:00 Discussion 10:00-11:15 Chairing: T. Tran, PhD, Singapore, Singapore C.W. Emala, MD, New York, NY C.A. Singer, PhD, Reno, NV 701 TMEM16A Agonism Contracts Airway Smooth Muscle in In Vivo and Ex Vivo Models/ J. Danielsson, A. Kuforiji, Y. Zhang, C.W. Emala, New York, NY, p.A2839 702 Inhaled Pitavastatin Reduces Airway Smooth Muscle Contraction/ A.A. Zeki, R.A. Lu, X. Ai, K. Chmiel, R. Krishnan, C. Ghosh, Davis, CA, p.A2840 703 Budesonide Augments Receptor-Dependent and -Independent Bronchodilation of Human Small Airways and Localized cAMP Production in Human Airway Smooth Muscle/ C. Koziol-White, T. Johnstone, R. Ostrom, R.A. Panettieri, New Brunswick, NJ, p.A2841 704 Anti-Remodelling and Anti-Airway Hyperresponsiveness Properties of Anti-Malarial Drug, Artesunate, in a House Dust Mites-Induced Chronic Mouse Model of Asthma/ D.H.J. Cheong, A.S.L. Phua, I.R.J. Tan, Y. Qiao, J. Dong, F.W.S. Wong, T. Tran, Singapore, Singapore, p.A2842 705 Modulation of cAMP Levels for Potentiation of Long-Acting Beta-Agonist and Glucocorticoids in Human Airway Epithelial Cells/ Y. Kim, V. Hou, J.P. Nguyen, R.D. Huff, M. Bianca, Y.J. Cheon, N. Tiessen, C. Cao, M. Heller, M.D. Inman, J.A. Hirota, Hamilton, Canada, p.A2843 706 Potential Differences in Calcium Sensitization Driving Human Small Airway Smooth Muscle Contractility in Obstructive Disease/ F. Sanai, A. Cairncross, P.B. Noble, J.G. Elliot, A.L. James, G.G. King, B.E. McParland, Sydney, Australia, p.A2844 707 TRPA1 Agonists Have Opposing Effects on Airway Nerves Versus Airway Smooth Muscle/ B. Marsh, A. Fryer, D.B. Jacoby, M.G. Drake, Portland, OR, p.A2845 708 Is Rho-Kinase Expression Up-Regulated in Asthmatic Airway Smooth Muscle?/ L. Wang, P. Chitano, P.D. Paré, C.Y. Seow, Vancouver, Canada, p.A2846 709 The Proprotein Convertase Furin Suppresses the Inflammatory Responses of Airway Smooth Muscle (ASM) Tissues to IL-13 by Modulating Integrin-Mediated Signaling Pathways/ W. Zhang, Y. Wu, Y. Huang, S.J. Gunst, Indianapolis, IN, p.A2847 710 S100A4 Regulates Airway Smooth Muscle (ASM) Inflammation by Acting on Receptors for Advanced Glycation End Products (RAGE)/ W. Zhang, Y. Wu, S.J. Gunst, Indianapolis, IN, p.A2848 711 Biased Regulation of OGR1 Biased Signaling in Airway Smooth Muscle Cells: GRK2/3 and Arrestin Potluck/ T. Pera, E. Tompkins, D.A. Deshpande, A.P. Nayak, R.B. Penn, Philadelphia, PA, p.A2849 712 IL-17A Reduces the Proliferative Capacity of Asthmatic Airway Smooth Muscle Independent of TGF-~1 Concentration via Altered ERK1/2 Signaling and Modulated miR-106b~25-dependent IP3R1 and TGF?R2 Expression/ J. Evasovic, C. Adajar, M.A. Hernandez, M.A. Ba, C.A. Singer, Reno, NV, p.A2850 713 Human Rhinovirus Infection Induces the Expression and Secretion of Endothelin-1/ M.J. O’Sullivan, J. Mitchel, Y.A. Bochkov, L.H. Tan, T. Kebadze, S.L. Johnston, J.E. Gern, J.-A.A. Park, Boston, MA, p.A2851 714 Dysregulation of microRNA-25 Modulates Airway Smooth Muscle Cell Proliferation via the Mammalian Target of Rapamycin Pathway by Targeting Tuberous Sclerosis Complex 1/ M.A. Hernandez, M.A. Ba, J. Evasovic, C.A. Singer, Reno, NV, p.A2852 715 Modulation of CD4+T Cell Properties by Airway Smooth Muscle Cell Mediated Inflammation/ J. Jang, M. Chen, S. Farahnak, J.G. Martin, Montreal, Canada, p.A2853 716 Allergic Airway Inflammation and Airway Hyperresponsiveness Are Independently Controlled by Diacylglycerol Kinase/ B. Singh, W. Lu, A.M. Schmidt Paustian, A. Haczku, R.A. Panettieri, D.A. Deshpande, T. Kambayashi, Philadelphia, PA, p.A2854 717 Circular RNA Expression in Mild/Moderate Versus Severe House Dust Mite (HDM) Mouse Models of Asthma/ W.T. Gerthoffer, S.C. Ramelli, T. Zhou, Reno, NV, p.A2855 718 Inhibition of Acetylcholine Esterase Attenuates In Vivo Airway Hyperreactivity and Lung Inflammation in a Model of Murine Asthma/ M. Mikami, G.T. Yocum, S. Kahan, C.W. Emala, New York, NY, p.A2856 719 Inflammation Amplifies the Phenomenon of Force Adaptation in a Mouse Model of Allergic Asthma/ M. Gazzola, F. Khadangi, K. Lortie, C. Henry, Y. Bossé, Quebec, Canada, p.A2857 720 Dasatinib and Quercetin Reverse Hyperoxia-Induced Airway Hyperreactivity in a Murine Model of Premature Airways Disease/ P. Parikh, R.D. Britt, S.A. Wicher, A.M. Roesler, B. Roos, L. Manlove, N. Lebrasseur, J. Kirkland, C.M. Pabelick, Y.S. Prakash, Rochester, MN, p.A2858 721 Combining Secreted and Lung Tissue Proteome Reveals Unique Pathobiological Pathways Associated with House Dust Mite Challenge in Mice/ T.H. Mahood, C. Pascoe, A. Jha, S. Basu, P. Ezzati, V. Spicer, N. Mookherjee, A.J. Halayko, Winnipeg, Canada, p.A2859 722 Intranasal Simvastatin Reverses Chronic Allergen Challenge-Induced Lung Inflammation, Remodelling and Dysfunction in a Murine Model of Asthma/ A. Jha, M.H. Ryu, M. Soussi-Ghounni, S. Basu, J. Schwartz, L. Mostaço-Guidolin, T.-L. Hackett, A.J. Halayko, Winnipeg, Canada, p.A2860 ATS 2019 • Dallas, TX 142 MONDAY • MAY 20