ATS 2019 Virtual Final Program

Chairing: M.T. Gladwin, MD, Pittsburgh, PA Y.-C.C. Lai, PhD, Indianapolis, IN F. Potus, PhD, Kingston, Canada F. De Man, PhD, Amsterdam, Netherlands 201 Two Single-Beat Estimates of the Right Ventricular Maximum Isovolumic Pressure Compared to the Gold-Standard Multi-Beat Approach in Human Subjects/ A. Muralidhar, S. Hsu, S.C. Mathai, T.M. Bull, R.J. Tedford, K.S. Hunter, Aurora, CO, p.A2795 202 A Novel Comparison of a Multi-Harmonic Approach to Estimate the Ventricular Vascular Coupling Ratio in Human Subjects/ A. Muralidhar, S. Hsu, S.C. Mathai, T.M. Bull, R.J. Tedford, K.S. Hunter, Aurora, CO, p.A2796 203 Interleukin-6 as a Potential Modulator of Right Ventricular Function Via the Microtubule-Junctophilin-2-T-Tubule Pathway/ K. Prins, L. Rose, L. Tian, D. Wu, T. Thenappan, S.L. Archer, Minneapolis, MN, p.A2797 204 Leptin Modulates Insulin Signaling Protein Intermediates Involved in Fatty Acid Metabolism in Cultured Cardiomyocytes with BMPR2 Mutation/ M. Talati, N. Fortune, E. Hornsby, J.D. West, A. Hemnes, Nashville, TN, p.A2798 205 Novel Dynamin-Related Protein 1 GTPase Inhibitor Prevents Myocardial Ischemia-Reperfusion Injury/ D. Wu, A. Dasgupta, K.-H. Chen, T. Hurst, M. Neuber-Hess, A. Martin, J. Mewburn, P.D.A. Lima, M. Wells, V. Snieckus, S.L. Archer, Kingston, Canada, p.A2799 206 FHL-1 Is Dispensable for Pressure Overload-Induced Maladaptive Right Ventricular Remodeling and Dysfunction/ C. Veith, D. Neghabian, H. Luitel, J. Wilhelm, B. Egemnazarov, C. Muntanjohl, J.-H. Fischer, B.K. Dahal, R.T. Schermuly, H.A. Ghofrani, F. Grimminger, L. Fink, G. Kwapiszewska, N. Weissmann, A. Sydykov, Giessen, Germany, p.A2800 207 A Novel Transcriptomic Signature Distinguishes Right Ventricular Adaptation at the Outset of Hypoxia-Induced Pulmonary Hypertension/ R.D. Brown, S.R. Riddle, N. Campbell, A.L. Frump, T. Lahm, B.B. Graham, K.R. Stenmark, Aurora, CO, p.A2801 208 Novel Rodent Model of Exercise-Induced Pulmonary Hypertension (EIPH) in Heart Failure with Preserved Ejection Fraction/ T. Satoh, L. Wang, A. Levine, Y.C. Lai, M.T. Gladwin, Pittsburgh, PA, p.A2802 209 Mechanisms of Hyperventilation in Heart Failure with Preserved Ejection Fraction/ M. Faria Urbina, R. Oliveira, A.B. Waxman, D.M. Systrom, Boston, MA, p.A2803 210 Looking Outside of the Lung to Treat Pulmonary Hypertension Due to Left Heart Disease; Lessons from a Novel Humanized Model of HFpEF-PH/ M. Fini, M. Li, V. Karoor, T. Sullivan, K.R. Stenmark, Aurora, CO, p.A2804 211 Examination of the Interventricular Septum to Discriminate Group 2 from Non Group 2 Pulmonary Hypertension/ N.V. Turlapati, A. Jakkoju, A. Vaidya, B.P. deBoisblanc, M.R. Lammi, New Orleans, LA, p.A2805 212 Urine and Plasma Nitrate After Oral Nitrate Administration in Patients with PH-HFpEF Compared to Healthy Controls/ N. Britton, C. Koch, A. Levine, N. Helbling, S. Shiva, M. Simon, M.T. Gladwin, A.M. Morris, Pittsburgh, PA, p.A2806 213 Right Atrial to Pulmonary Artery Wedge Pressure (RA/PAWP) Ratio Across the Hemodynamic Spectrum in Pulmonary Hypertension/ A. Van, N. Turlapati, A. Jakkoju, B.P. deBoisblanc, M.R. Lammi, New Orleans, LA, p.A2807 214 NEBI as a Potential Means of Differentiating PAH and HFpEF Independent of PCWP/ M. Passineau, P. Gallo, R. Perez, C. Horn, A. Chaturvedi, R.L. Benza, Pittsburgh, PA, p.A2808 215 Cardiac MRI: Identifying Thresholds to Predict Mortality in Pulmonary Arterial Hypertension/ R. Lewis, M. Cogliano, C.S. Johns, C.G. Billings, N. Hamilton, C.A. Elliot, A. Charalampopoulos, I. Sabroe, R. Thompson, R. Condliffe, J.M. Wild, A.J. Swift, D.G. Kiely, Sheffield, United Kingdom, p.A2809 216 Early Maladaptive Right Ventricular Remodeling in an Animal Model of Western Diet Induced Pulmonary Hypertension and Heart Failure/ V. Agrawal, N. Fortune, L. Gleaves, E. Hornsby, E. Brittain, J.D. West, A. Hemnes, Nashville, TN, p.A2810 217 Searching for a Novel Pharmacologic Treatment for PH-HFpEF: From HTS to Animal Models/ A. Levine, T. Lear, B. Xie, B. Chen, M. Jurczak, M.T. Gladwin, Pittsburgh, PA, p.A2811 218 Acute Hemodynamic Effects of Oral Nitrite in PH-HFpEF/ A. Levine, N. Helbling, N. Chien, M. Simon, M.T. Gladwin, Pittsburgh, PA, p.A2812 219 Accumulation of Ceramide in Cardiomyocytes with BMPR2 Mutation Decreases Apoptosis by Disrupting Akt/GSK-3b Signaling Pathway/ X. Zeng, M. Talati, W. Huang, N. Fortune, E. Hornsby, T. Blackwell, A. Rathinasabapathy, X. Chen, J. West, A. Hemnes, Nashville, TN, p.A2813 220 Intracoronary CDCs: Rescue of Right Ventricular Dysfunction Complicating Pulmonary Hypertension in the Sugen-Hypoxia Rat Model/ R.C. Middleton, M. Fournier, N.F. Voelkel, E. Marban, M.I. Lewis, Los Angeles, CA, p.A2814 221 Right Ventricular Fibrosis in Pulmonary Hypertension Is Mediated by ACh/nAChR Signaling/ A. Vang, J.H. Siamwala, R.T. Clements, N.R. Kue, T.J. Mancini, D.J. McCullough, A. Allawzi, G. Choudhary, Providence, RI, p.A2815 222 Pulmonary Arterial Stiffening in Pulmonary Hypertension Due to Left Heart Disease/ M.M. Kucherenko, P. Sang, D. Wulsten, G. Duda, W.M. Kuebler, C. Knosalla, Berlin, Germany, p.A2816 223 Group-Based Trajectory Modeling of Diastolic Function in Healthy Subjects and Patients with Pulmonary Arterial Hypertension/ Y. Han, J. Han, S. Altmayer, K. Addetia, A. Patel, Philadelphia, PA, p.A2817 224 Treatment with Treprostinil and Metformin Normalizes Hyperglycemia and Improves Cardiac Function in Pre-Clinical Model of Pulmonary Hypertension Associated with Heart Failure with Preserved Ejection Fraction (PH-HFpEF)/ L. Wang, T. Satoh, J. Baust, J. Hu, A.L. Mora, M.T. Gladwin, Y.C. Lai, Pittsburgh, PA, p.A2818 225 Ratio of Stroke Volume to End-Systolic Volume Predicts Change in Right Ventricular Ejection Fraction in Patients with Pulmonary Arterial Hypertension/ R.R. Vanderpool, J. Holmathchi, R. Puri, S. Airhart, H. Erickson, A. Lizarraga, L. Hansen, S. Kubba, R. Janardhanan, R. Naeije, J.G.N. Garcia, J.X.J. Yuan, F.P. Rischard, Tucson, AZ, p.A2819 ATS 2019 • Dallas, TX 140 MONDAY • MAY 20