ATS 2019 Virtual Final Program

Oral Presentations 2:15 DNMT3A and TET2 Mutations: Linking Genetics and Epigenetics in Pulmonary Arterial Hypertension/ F. Potus, E.K. Cook, A. Hsieh, M. Pauciulo, C. Welch, N. Zhu, L. Tian, P. Lima, C. D’Arsigny, Y. Shen, P.M. Hassoun, W.C. Nichols, W.K. Chung, M.J. Rauh, S.L. Archer, Kingston, Canada, p.A2397 2:30 Pericytes Differentiate into Smooth Muscle Cells Through CXCL12 Activation in Hypoxia Induced PH/ K. Yuan, W. Zhang, E. Shamskhou, M. Orcholski, A. Nathan, V. De Jesus Perez, Palo Alto, CA, p.A2398 2:45 Stiffness-Induced TSC2 Deficiency Promotes Vascular Smooth Muscle Remodeling and Pulmonary Hypertension Via Yap/mTOR Axis/ Y. Shen, A. Pena, T.V. Kudryashova, D.A. Goncharov, B. Chang, A.L. Mora, J. Baust, A. Chavez Barragan, A. Ray, A. Rode, E.A. Goncharova, Pittsburgh, PA, p.A2399 3:00 Homeostatic Role for the P53-Dependent Toll-Like Receptor 3 Expression in the Pulmonary Endothelium/ A.R. Bhagwani, D. Farkas, E.A. Goncharova, A.A.R. Thompson, L. Farkas, Richmond, VA, p.A2400 3:15 Engineering of Endothelium-Derived Extracellular Vesicles with Altered miRNA Cargo to Treat Severe Pulmonary Hypertension/ T. Chen, Q. Zhou, M. Sun, R. Ramchandran, J.U. Raj, Chicago, IL, p.A2401 3:30 Loss of Wnt7a Reduces Tip Cell Driven Angiogenesis and Contributes to Small Vessel Loss in Pulmonary Arterial Hypertension/ A. Chakraborty, M. Orcholski, K. Yuan, E. Shamskhou, J.T. Crossno, T. Spencer, R.A. Winn, V. De Jesus Perez, Palo Alto, CA, p.A2402 3:45 Long Non-Coding RNA H19 in the Pathogenesis of Right Ventricular Failure Associated with Pulmonary Arterial Hypertension -A Putative Novel Biomarker and Therapeutic Target-/ J. Omura, K. Habbout, S. Martineau, S. Breuils-Bonnet, V. Nadeau, F. Potus, S.L. Archer, R. Paulin, S. Provencher, O. Boucherat, S. Bonnet, Quebec City, Canada, p.A2403 4:00 Platelet aIIbß3 Promotes Acute Pulmonary Thromboembolism/ T. Brzoska, R. Vats, M.F. Bennewitz, E. Tutuncuoglu, S.C. Watkins, M.V. Ragni, M.D. Neal, M.T. Gladwin, P. Sundd, Pittsburgh, PA, p.A2404 BASIC • CLINICAL • TRANSLATIONAL MINI SYMPOSIUM A98 PHENOTYPING COPD AND PREDICTING THE DISEASE PROGRESSION 2:15 p.m. - 4:15 p.m. KBHCCD Room C155-C156 (Level 1) Chairing: Y. Nakano, MD, PhD, Otsu Shiga, Japan S.R. Hopkins, MD, PhD, La Jolla, CA D.G. Chapman, BSc, PhD, Glebe, Australia Oral Presentations 2:15 Novel Multi-Parametric Response Map COPD Phenotypes/ J. MacNeil, D.P.I. Capaldi, A. Westcott, D.G. McCormack, G. Parraga, London, Canada, p.A2405 2:30 Identification of Gas Exchange Phenotypes Using Hyperpolarized 129 Xe MRI in Patients with Chronic Obstructive Pulmonary Disease (COPD)/ J. Mammarappallil, E. Coleman, M. He, Z. Wang, E. Bier, J. Nouls, S. Womack, Y. Lee, H.P. McAdams, B. Driehuys, Y.-C.T. Huang, Durham, NC, p.A2406 2:45 Beyond Chronic Bronchitis and Emphysema: Characterization of a Transcriptomically Unique COPD Phenotype with Hyperpolarized 129 Xe MRI/ L.A. Myc, J. Mata, Y. Huang, S. Callahan, G.W. Miller, T. Altes, M. Bergman, J. Mugler, Y.M. Shim, Charlottesville, VA, p.A2407 3:00 Transcriptomic Pattern of COPD Frequent Exacerbators/ J.G. Gea, S. Pascual-Guardia, A. Castro-Acosta, F. Casals, L. Seijo, G. Peces-Barba, J.L. Lopez-Campos, B.G. Cosio, R. Fane, A. Agustí, E. Monsó, R. Castelo, Barcelona, Spain, p.A2408 3:15 COPD Phenotyping and Differential Therapy Can Be Improved Using Impulse Oscillometry and Multiple Breath Washout Testing/ F. Trinkmann, J. Schaefer, J. Gawlitza, J. Drayss, M. Schroeter, J.D. Michels, I. Akin, M. Borggrefe, J. Saur, Mannheim, Germany, p.A2409 3:30 Radiographic Lung Volumes Predict Progression to COPD in Smokers with Preserved Spirometry in SPIROMICS/ M. Arjomandi, S. Zeng, I. Barjaktarevic, R.G. Barr, E.R. Bleecker, R.P. Bowler, R.G. Buhr, A.P. Comellas, C.B. Cooper, D. Couper, J.L. Curtis, M.T. Dransfield, M.K. Han, N.N. Hansel, E.A. Hoffman, R.J. R.E. Kanner, J.A. Krishnan, R. Paine, S.P Peters, S.I. Rennard, P. Woodruff, San Francisco, CA, p.A2410 3:45 CT-Based Airway Surface Area to Volume Ratio Is Associated with Lung Function Decline in Chronic Obstructive Pulmonary Disease (COPD)/ S. Bodduluri, A. Nakhmani, P. Kandhare, T.R. Patel, J.M. Reinhardt, C. Wilson, H.P. Nath, M.T. Dransfield, S.P. Bhatt, Birmingham, AL, p.A2411 4:00 Longitudinal Changes of Respiratory Impedance-Based Phenotyping and Disease Probability Measure in COPD/ Y. Matsuo, E. Ogawa, R. Yukimura, A. Yamazaki, S. Kawashima, D. Kinose, M. Yamaguchi, T. Nagao, Y. Nakano, Otsu, Japan, p.A2412 BASIC • CLINICAL • TRANSLATIONAL RAPID: RAPID ABSTRACT POSTER DISCUSSION SESSION A101 TRANSLATIONAL STUDIES IN ILD, IPF, AND SARCOIDOSIS 2:15 p.m. - 4:15 p.m. KBHCCD Room D222-D224 (Level 2) Abstract Summaries 2:15-2:45 Viewing/Discussion 2:45-4:15 ATS 2019 • Dallas, TX SUNDAY • MAY 19 107 SUNDAY AFTERNOON