ATS 2019 Virtual Final Program

Chairing: R.S. Knipe, MD, MGH, Boston, MA A. Lam, MD, Chicago, IL D.N. O’Dwyer, MBChB, PhD, Ann Arbor, MI 501 Decay-Accelerating Factor 1 Gene Silencing Exacerbates Alveolar Injury and Fibrotic Responses in Mice/ R. Vittal, M. Agarwal, C. Wilke, E. Cipolla, K.K. Kim, V.N. Lama, B.B. Moore, Ann Arbor, MI, p.A2413 502 Doxycycline Alleviates Paraquat Induced Acute Lung Injury Via Inhibiting Neutrophil-Derived Matrix Metalloproteinase 9/ H. Sun, F. Zhang, Y. Wu, L. Fan, W. Liu, J. Zhang, Nanjing, China, p.A2414 503 Non-Canonical Actions of PI3Kg Drive Plasma Membrane Translocation of TRPV4/PI3K g Complexes and Myofibroblast Differentiation/ M.A. Olman, L. Grove, M.L. Mohan, S. Abraham, R.G. Scheraga, B.D. Southern, J.F. Crish, S.V. Naga Prasad, Cleveland, OH, p.A2415 504 Nailfold Capillaroscopy in a Prospective Interstitial Lung Disease (ILD) Cohort: IPF, CTD-ILD and IPAF/ A.S.-Y. Jee, M. Parker, N. McGill, J. Bleasel, L. Troy, H. Jo, E.M.T. Lau, S. Webster, M. Geis, T.J. Corte, Sydney, Australia, p.A2416 505 Plasma Biomarkers of Survival in Patients with Interstitial Lung Disease/ S. Alqalyoobi, A. Linderholm, C. Mendez, B.M. Morrissey, R.W. Harper, J. Oldham, Sacramento, CA, p.A2417 506 Acute Exacerbation of Chronic Hypersensitivity Pneumonitis: Incidence, Risk Factors and Outcome/ Y.J. Kim, J.W. Song, D.S. Kim, Seoul, Korea, Republic of, p.A2418 507 The Role of B-1 Cells and IgM to Oxidation-Specific Epitopes in Pulmonary Inflammation and Fibrosis/ J.M. Sturek, A.D. Upadhye, A. Kadl, C.A. McNamara, Charlottesville, VA, p.A2419 508 Targeting Glutamine Metabolism as a Novel Means of Arresting and Reversing Pulmonary Fibrosis/ M.R. Horton, S. Collins, C.L. Vigeland, Y. Chan-Li, M. Oh, P. Majer, R. Rais, B. Slusher, J. Powell, Baltimore, MD, p.A2420 509 ATYR1923 Modulates the Inflammatory Response in Experimental Models of Interstitial Lung Disease/ C. Burkart, M. Seikkula, L. Eide, S. Paz, D. Chu, C. Polizzi, D. King, S. Rosengren, K. Ogilvie, San Diego, CA, p.A2421 510 Deletion of Galectin-3 in Myeloid Cells Inhibits Bleomycin-Induced Lung Fibrosis/ A.C. Mackinnon, D. Humphries, R. Mills, N. Hirani, N. Henderson, T. Sethi, A. Rossi, Edinburgh, United Kingdom, p.A2422 511 Role of B7H3/IL-33 Signaling in Pulmonary Fibrosis-induced Alterations in Bone Marrow/ T. Liu, T. Nakashima, F. Gonzalez De Los Santos, B. Hu, Z. Wu, S.H. Phan, Ann Arbor, MI, p.A2423 512 The Role of IRAK-M in Regulating Monocyte Trafficking to the Lung Following Bleomycin Challenge/ M.N. Ballinger, B. Reader, R.V. Thomas Becket, J.W. Christman, Columbus, OH, p.A2424 513 T Cell Phenotype in Peripheral Blood of Patients with Idiopathic Pulmonary Fibrosis/ A. Serezani, B. Pascoalino, K. Vowell, J. Kropski, T.S. Blackwell, Nashville, TN, p.A2425 514 Short-Term Longitudinal Gene Expression Changes Predict Forced Vital Capacity Decline in Idiopathic Pulmonary Fibrosis/ Y. Huang, J. Oldham, S.F. Ma, P.-C. Hou, M.E. Strek, P.L. Molyneaux, T.M. Maher, N. Kaminski, J.D. Herazo-Maya, F.J. Martinez, I. Noth, Charlottesville, VA, p.A2426 515 Mucosal-Associated Invariant T Cells Are Activated in Lungs of Sarcoidosis/ H. Matsuyama, T. Isshiki, A. Chiba, T. Yamaguchi, G. Murayama, Y. Akasaka, Y. Eishi, S. Miyake, S. Homma, Tokyo, Japan, p.A2427 516 Development of a Sarcoidosis-Like Granuloma in Vitro Model Using Peripheral Blood Mononuclear Cells of Patients with Sarcoidosis/ R. Tian, C. Zhang, G.E. Holt, K. Schesser, N. Altman, R.M. Jackson, M. Mirsaeidi, Miami, FL, p.A2428 517 PPAR g Deficiency Exacerbates Fibrotic Response to Mycobacteria Peptide in a Murine Model of Pulmonary Sarcoidosis/ A. Malur, A. Mohan, R.A. Barrington, N. Leffler, G. Murray, K. Kew, B.P. Barna, M.J. Thomassen, Greenville, NC, p.A2429 518 Matrix Metalloproteinase-12 Is Critical for Granuloma Formation in a Murine Model of Sarcoidosis/ A. Mohan, N. Neequaye, A. Malur, W. Knudson, S.A. Gharib, L.M. Schnapp, M.J. Thomassen, Greenville, NC, p.A2430 519 Genetic Architecture of Disease Chronicity in Sarcoidosis/ N.V. Rivera, S. Kullberg, T. Iseda, A.G. Eklund, L. Padyukov, J. Grunewald, Stockholm, Sweden, p.A2431 520 Gender Differences in Sarcoidosis Mediated by PD-1, and T H 17 Pathway/ O.S. Chioma, L.J. Celada, K. Abel, D.C. Newcomb, W.P. Drake, Nashville, TN, p.A2432 521 Inflammatory Biomarkers in Patients with Sarcoidosis Associated Pulmonary Hypertension: The Registry of Sarcoidosis Associated Pulmonary Hypertension (ReSAPH)/ P. Heukels, J. van Hulst, M. van Nimwegen, M. Wijsenbeek, R.P. Baughman, M. Kool, Rotterdam, Netherlands, p.A2433 522 Transcriptomic Profiling Via RNA Sequencing of Peripheral Blood Single Cells and Granulomas Reveals Immunosuppression in Sarcoidosis/ L. Garman, R. Pelikan, C. Lareau, K.A. White, A. Rasmussen, O.S. Chioma, W.P. Drake, C. Montgomery, Oklahoma City, OK, p.A2434 523 The Prognostic Value of Monocyte Count in Idiopathic Pulmonary Fibrosis: A Multi-Omic Cohort Study/ M. Scott, K. Quinn, Q. Li, R. Carroll, S. Chen, M. Carns, K. Aren, J. Sun, K. Koloms, J. Lee, J. Kropski, H. Zhao, E. Herzog, F.J. Martinez, B.B. Moore, M. Hinchcliff, J. Denny, N. Kaminski, J.D. Herazo-Maya, N. Shah, P. Khatri, Stanford, CA, p.A7342 524 Chronic Hypersensitivity Pneumonitis (CHP), an ILD with Distinct Molecular Signatures/ H. Furusawa, J. Cardwell, T. Okamoto, A.D. Walts, M.I. Schwarz, C.D. Cool, P.J. Wolters, J.S. Lee, I.V. Yang, D.A. Schwartz, Aurora, CO, p.A7343 CLINICAL RAPID: RAPID ABSTRACT POSTER DISCUSSION SESSION A102 COPD: THERAPY 2:15 p.m. - 4:15 p.m. KBHCCD Room C141/C143/C149 (Level 1) Abstract Summaries 2:15-2:45 Viewing/Discussion 2:45-4:15 ATS 2019 • Dallas, TX 108 SUNDAY • MAY 19