ATS 2019 Virtual Final Program

BASIC • CLINICAL • TRANSLATIONAL MINI SYMPOSIUM A95 CRITICAL CARE: ALICE IN WONDERLAND - BIOMARKERS IN CRITICAL ILLNESS: CLUES TO BE UNRAVELLED 2:15 p.m. - 4:15 p.m. OMNI DALLAS DOWNTOWN Trinity Ballroom 4/8 (Level 3) Chairing: C.S. Calfee, MD, San Francisco, CA E.P. Schmidt, MD, Aurora, CO Oral Presentations 2:15 A Multicenter Parsimonious Biomarker Mortality Prediction Model for Sepsis-Induced ARDS/ M.G. Kashiouris, X. Qiao, B.J. Fisher, J.D. Truwit, R.D. Hite, P.E. Morris, G.S. Martin, A.A. Fowler, Richmond, VA, p.A2381 2:30 Serum Biomarkers of Mitochondrial Myopathy, Strength, and Recovery in Older Survivors of Acute Respiratory Failure/ B.J. Rosenberg, W.C. Gonzalez, M. Hirano, C. Quinzii, D.J. Lederer, M.R. Baldwin, New York, NY, p.A2382 2:45 Genome-Wide Association Study Implicates a Vascular Endothelial Grown Factor Receptor in Sepsis-Induced Acute Respiratory Distress Syndrome/ B. Guillen-Guio, J.M. Lorenzo-Salazar, T. Hernandez-Beeftink, A. Corrales, S.F. Ma, E. Espinosa, A. Muriel, D. Domínguez, L. Lorente, M.M. Martín, C. Rodríguez-Gallego, J. Solé-Violán, A. Ambrós, D. Carriedo, J. Blanco, J.M. Añón, J.P. Reilly, T.K. Jones, C.A.G. Ittner, R. Feng, F. Schoneweck, M. Kiehntopf, M. Sholz, F.M Brunkhorst, A. Sherag, N.J. Meyer, J. Villar, C. Flores, Santa Cruz de Tenerife, Spain, p.A2383 3:00 Haptoglobin Genotype Modifies Risk of ARDS During Clinical and Experimental Sepsis/ V.E. Kerchberger, C.M. Shaver, J.B. McNeil, N.D. Putz, S.R. Landstreet, N.E. Wickersham, J.A. Bastarache, L.B. Ware, Nashville, TN, p.A2384 3:15 Novel Approach to Identifying Leukocyte Functional Heterogeneity in Patients with Early Sepsis Based on Endotoxin Tolerance/ A. Leligdowicz, A. Jauregui, K. Vessel, J. Abbott, X. Tian, A. Prakash, K. Liu, C.S. Calfee, M.A. Matthay, Toronto, Canada, p.A2385 3:30 Impact of Bilateral Infiltrates on the Inflammatory Biomarker Profile and Clinical Outcomes of Children with Oxygenation Defect/ J. Kohne, M.K. Dahmer, H.M. Weeks, N. Kaciroti, M.W. Quasney, A. Sapru, M.A.Q. Curley, M.A. Matthay, H.R. Flori, Ann Arbor, MI, p.A2386 3:45 Transcriptomic Profiles of Sepsis in the Human Brain/ A.C. Bustamante, K. Opron, T.J. Standiford, B. Singer, Ann Arbor, MI, p.A2387 4:00 Validation of a 12-mRNA Score for Mortality Risk Stratification in Critically Ill Patients/ A. Moore, J. Roque, B.D. Shaller, T. Asuni, J.E. Levitt, J.G. Wilson, P. Khatri, M. Remmel, D. Rawling, M. Eshoo, T.E. Sweeney, A.J. Rogers, Stanford, CA, p.A2388 BASIC • CLINICAL • TRANSLATIONAL MINI SYMPOSIUM A96 NEW MECHANISMS OF OZONE TOXICITY 2:15 p.m. - 4:15 p.m. OMNI DALLAS DOWNTOWN Dallas BallroomG (Level 3) Chairing: J.G. Wagner, MBA, PhD, East Lansing, MI P. Silveyra, PhD, MSc, Chapel Hill, NC R.M. Tighe, MD, Durham, NC Oral Presentations 2:15 Fecal Transplant with an Obese Microbiome Augments Pulmonary Responses to Ozone in Mice/ H. Tashiro, V.Y. Yeliseyev, A.P. Cardoso, R. Osgood, L. Bry, S.A. Shore, D.I. Kasahara, Boston, MA, p.A2389 2:30 Androgens Alter the Pulmonary Response to Ozone in Mice/ R.S. Osgood, D.I. Kasahara, H. Tashiro, Y. Cho, A.P. Cardoso, S.A. Shore, Boston, MA, p.A2390 2:45 Accumulations of Innate Lymphoid Cells and Eosinophils in the Nasal Mucosa of Mice Repeatedly Exposed and Re-Exposed to the Gaseous Air Pollutant Ozone/ J.R. Harkema, E. Eldridge, R. Lewandowski, P. Akbari, J.G. Wagner, East Lansing, MI, p.A2391 3:00 The Microbiome but Not IL-33 Contributes to Ozone-Induced Airway Hyperresponsiveness in Male Mice with Diet Induced Obesity/ D.I. Kasahara, Y. Cho, A.P. Cardoso, S.A. Shore, Boston, MA, p.A2392 3:15 Investigating Susceptibility to Ozone-Induced Lung Inflammation and Injury Using the Collaborative Cross Mouse Genetic Reference Population/ A.E. Tovar, G.J. Smith, J. Thomas, K. McFadden, S.N. Kelada, Chapel Hill, NC, p.A2393 3:30 Ozone-Derived Oxysterols Modulate Epithelial Cell and Macrophage Function in the Lung/ P. Duffney, A.M. Speen, H.-Y.H. Kim, N.A. Porter, I. Jaspers, Chapel Hill, NC, p.A2394 3:45 Early Life Ozone Exposure Results in Dysregulation of Wnt11 Expression in the Respiratory Tract of Nonhuman Primates/ T. Burgess, M.G. dela Pena-Ponce, L.A. Miller, Davis, CA, p.A2395 4:00 Long-Term Ozone and PM 2.5 Exposure Is Positively Associated with Telomere Length in Critically Ill Patients/ C. Wang, P.J. Wolters, C.S. Calfee, S. Liu, J.R. Balmes, T. Koyama, Z. Zhao, L.B. Ware, Nashville, TN, p.A2396 BASIC • TRANSLATIONAL MINI SYMPOSIUM A97 STATION TO STATION: UNRAVELING THE MOLECULAR PATHOGENESIS OF PAH 2:15 p.m. - 4:15 p.m. KBHCCD Room C147/C148/C154 (Level 1) Chairing: S. Bonnet, PhD, MSc, Quebec City, Canada E.A. Goncharova, PhD, Pittsburgh, PA K.R. Stenmark, MD, Aurora, CO ATS 2019 • Dallas, TX 106 SUNDAY • MAY 19