ATS 2019 Virtual Final Program

BASIC • CLINICAL • TRANSLATIONAL MINI SYMPOSIUM A93 ASTHMA BREAKTHROUGHS: THE ROLE OF THE IMMUNE SYSTEM IN HUMAN ASTHMA 2:15 p.m. - 4:15 p.m. KBHCCD Room D221/D225/D226 (Level 2) Chairing: P. Akuthota, MD, La Jolla, CA G.G. Brusselle, MD, PhD, Ghent, Belgium Oral Presentations 2:15 High Dimensional Immunophenotyping Identifies Diversity Within Severe Asthmatics/ M. Camiolo, X. Zhou, T.B. Oriss, P. Ray, J.K. Kolls, K.C. Nadeau, S.E. Wenzel, A. Ray, Pittsburgh, PA, p.A2366 2:30 Airway Dendritic Cells in Allergic Asthmatics Respond to Allergen via Differential Expression of Tolerogenic and Innate Sensing Genes/ J. Alladina, R.A. Rahimi, J.W. Griffith, K.M. Discipio, D.L. Hamilos, A.D. Luster, B.D. Medoff, J.L. Cho, Boston, MA, p.A2367 2:45 CD103 + Lung Tissue Resident Memory T Cells (TRM) Represent an Airway Centered, Clonally Expanded Subset of TRM with ZNF683 (Hobit) Expression Differentiating CD4+and CD8+CD103+TRM/ M.E. Snyder, F. Cvetkovski, P. Dogra, P. Szabo, M. Miron, D. Carpenter, T. Senda, D. Farber, Pittsburgh, PA, p.A2368 3:00 Human Lung CD4 and CD8 Tissue Resident Memory T Cells Have Distinct Transcriptional Programming from Phenotypically Identical Cells in Lung Draining Lymph Node and Activate Asthma-Related Pathways After T Cell Receptor Stimulation/ N. Schoettler, C.L. Hrusch, A.I. Sperling, C. Ober, Chicago, IL, p.A2369 3:15 Investigation of Basophils in Aspirin Exacerbated Respiratory Disease Pathogenesis/ W. Stevens, A. Staudacher, J. Poposki, A. Kato, K. Hulse, L. Suh, J. Norton, R. Carter, L. Grammer, A. Peters, D. Conley, S. Shintani-Smith, B. Tan, K. Welch, R. Kern, R. Schleimer, Chicago, IL, p.A2370 3:30 A Ferroptosis-Related Gene Signature Predicts Exacerbation-Prone Asthma/ S. Xue, J. Zhao, S.M. Nouraie, S. Christenson, M.C. Peters, J.V. Fahy, P. Woodruff, E.R. Bleecker, D.A. Meyers, L.C. Denlinger, N.N. Jarjour, M. Castro, E. Israel, B.D. Levy, S.C. Erzurum, B.M. Gaston, A. Ray, V.E. Kagan, S.E. Wenzel, Pittsburgh, PA, p.A2371 3:45 Regulation of the Intracellular Glutathione Redox State in Asthma/ T. Nagasaki, Y. Deng, J.B. Trudeau, Y. Minami, N. Bonfiglio, J. Zhao, S.E. Wenzel, Pittsburgh, PA, p.A2372 4:00 Exhaled Volatile Organic Compounds Are Able to Discriminate Between Neutrophilic and Eosinophilic Asthma/ F. Schleich, D. Zanella, P.-H. Stefanuto, J. Dallinga, M. Henket, E.F.M. Wouters, K. Van Steen, F.-J. Van Schooten, J.-F. Focant, R. Louis, Liège, Belgium, p.A2373 BEHAVIORAL • CLINICAL MINI SYMPOSIUM A94 INNOVATIONS TO IMPROVE CARE IN OBSTRUCTIVE LUNG DISEASE 2:15 p.m. - 4:15 p.m. KBHCCD Room C146 (Level 1) Chairing: J.K. Gerald, MD, PhD, Tucson, AZ J.P. Wisnivesky, DrPH, MD, New York, NY Oral Presentations 2:15 Diagnostic Uncertainty as a Barrier to Guideline-Directed Care for Exacerbations of Chronic Obstructive Pulmonary Disease (COPD)/ B.R. Murray, L.J. Spece, E.M. Epler, L.C. Feemster, D.H. Au, Seattle, WA, p.A2374 2:30 Overuse and Misuse of Inhaled Corticosteroids Among Patients with COPD: Evaluating Patient, Provider and Clinic Level Targets for De-Implementation/ M. Griffith, L.C. Feemster, S. Zeliadt, L.M. Donovan, L. Spece, D.H. Au, Seattle, WA, p.A2375 2:45 The Association of COPD Inhaler Regimen on Mortality and Hospitalization: A Secondary Analysis of the Long-Term Oxygen Treatment Trial/ T. Keller, L. Spece, L.M. Donovan, E. Udris, M. Griffith, A. Bryant, W.C. Bailey, R. Casaburi, P.T. Diaz, A.L. Fuhlbrigge, R.E. Kanner, F.J. Martinez, F.C. Sciurba, A. Sternberg, J.K. Stoller, R.A. Wise, R.D. Yusen, D.H. Au, L.C. Feemster, Seattle, WA, p.A2376 3:00 Influenza Vaccine Effectiveness in Older Patients with Chronic Obstructive Pulmonary Disease (COPD)/ A.S. Gershon, H. Chung, J. Porter, M.A. Campitelli, S.A. Buchan, K.L. Schwartz, A. Campigotto, J.B. Gubbay, T. Karnauchow, K. Katz, A.J. McGeer, D. McNally, D.C. Richardson, A. Simor, M. Smieja, G. Zahariadis, J.C. Kwong, Toronto, Canada, p.A2377 3:15 Extended, 6 Weeks, Varenicline Preloading: Does It Facilitate Smoking Reduction and Cessation? A Randomized Double-Blind, Placebo-Controlled Study/ G. Izbicki, Y. Freier Dror, A. Bohadana, Jerusalem, Israel, p.A2378 3:30 The Effects of Hospital Outreach Intervention on Decreasing Hospitalizations and Medical Cost of Patients with Chronic Obstructive Pulmonary Disease/ J. Yan, L. Wang, C. Liu, Z. He, S. Zhu, L. Long, G. Yang, Changsha, China, p.A2379 3:45 Emergency Department Visits Were Among Older Adults with Asthma Receiving a Patient Tailored Self-Management Intervention: Results of a Randomized Trial/ A. Federman, R. O’Conor, J. Erblich, M.S. Wolf, J.P. Wisnivesky, New York, NY, p.A2380 Featured Speaker 4:00 Opportunities for Improving Care in Obstructive Lung Diseases/ L.C. Feemster, Seattle, WA ATS 2019 • Dallas, TX SUNDAY • MAY 19 105 SUNDAY AFTERNOON