ATS 2019 Virtual Final Program

Target Audience Medical practitioners, basic scientists, trainees involved in acute and chronic lung injury research and treatment, including IPF, pulmonary infections, ARDS, and lung cancer Objectives At the conclusion of this session, the participant will be able to: • learn new findings on the interactions of innate immunity and the microbiome in lung disease; • begin to understand how interactions between the microbiome and immunity can be used to influence patient outcomes in precision medicine approaches to lung disease; • learn the newest findings on genetic and genomic determinants of lung disease susceptibility and progression. There is strong research support that acute and chronic lung diseases such as asthma, COPD, and IPF are a result of maladaptive gene-by-environment interactions. Immune genes are leading factors for asthma, ARDS and IPF susceptibility and progression. Furthermore, the microbiome is now understood to play a role in lung biology. However, research has tended to investigate microbiome and immunity separately, and only recently has the interaction of the two been appreciated. This symposium will integrate recent findings on microbiome and immunity research, and highlight how microbiome-immune interactions lead to lung disease development and progression, with an emphasis on impact on lung diseases across multiple assemblies (asthma, sleep apnea, IPF, etc.) Chairing: S. Garantziotis, MD, Research Triangle Park, NC B.B. Moore, PhD, ATSF, Ann Arbor, MI C. Dela Cruz, MD, PhD, ATSF, New Haven, CT 2:15 The Lung Microbiome in Healthy Mice: Interactions with Environment, Exposures, and Immunity R.P. Dickson, MD, Ann Arbor, MI 2:35 Multi-System View of Microbiome-Immune Interactions in Adult Asthma Y.J. Huang, MD, Ann Arbor, MI 2:55 Host-Microbiome Interactions in Interstitial Lung Disease P.L. Molyneaux, MRCP(UK), MBBS, BS(Hons), London, United Kingdom 3:15 Could the Microbiome Protect From Pulmonary Fibrosis? S. Garantziotis, MD, Research Triangle Park, NC 3:35 Lung Microbiota, Host Inflammation and Immune Surveillance in Lung Cancer L.N. Segal, MD, New York, NY 3:55 The Lower Respiratory Tract Microbiome and Chronic Lung Allograft Dysfunction After Transplant J.E. McGinniss, MD, Philadelphia, PA BASIC • CLINICAL • TRANSLATIONAL SCIENTIFIC SYMPOSIUM CME Credits Available: 0 A92 HEALTH IMPACTS OF MARIJUANA: STATE OF THE SCIENCE AND FUTURE DIRECTIONS Assemblies on Environmental, Occupational and Population Health; Clinical Problems 2:15 p.m. - 4:15 p.m KBHCCD Ballroom A One (Level 2) Target Audience Providers of lung health and those needing instruction in areas of medicine outside of their specialty who may encounter patients or others using cannabis, or who would have questions about cannabis use for their medical problems. Objectives At the conclusion of this session, the participant will be able to: • understand the health impacts of marijuana use particularly as they apply to the lung and its host defense; • apply this knowledge in communications with his/her patients who admit to using or contemplate using marijuana for either recreational or medicinal purposes; • understand the addictive potential of marijuana regarding the risk of acquiring marijuana dependence. Most states in the U.S. have legalized marijuana use for medicinal and/or recreational use, suggesting that the prevalence of marijuana use, (currently ~22 million users each month), will rise, making an understanding of the health effects of marijuana increasingly important. This session will include presentations pertaining to the effects of marijuana on the lung and immune system from a translational and clinical perspective, the impact of marijuana on the brain with a focus on the cannabis dependence syndrome, potential therapeutic applications, and legal and health policy issues. Chairing: D.P. Tashkin, MD, ATSF, Los Angeles, CA E.L. Burnham, MD, Denver, CO 2:15 Introduction E.L. Burnham, MD, Denver, CO 2:25 Pulmonary Effects of Marijuana Smoking D.P. Tashkin, MD, ATSF, Los Angeles, CA 2:43 Potential Immune Consequences of Marijuana M.D. Roth, MD, Los Angeles, CA 3:01 Marijuana and Sleep G.L. Kenney, MPH, PhD, Aurora, CO 3:19 Marijuana Dependence: Impacts of Marijuana on the Brain K. Hutchison, PhD, Denver, CO 3:37 Potential Therapeutic Applications of Marijuana and Cannabinoids M. Ware, MBBS, MRCP (UK), Denver, CO 3:55 Parallels in Legislative Changes in Tobacco and Marijuana E.R. Neptune, MD, Baltimore, MD ATS 2019 • Dallas, TX 104 SUNDAY • MAY 19