ATS 2020 Advance Program

3:30 System Solutions: Athena Swan in the U.K. C. Summers, MBBS, PhD, Cambridge, United Kingdom 3:45 Beyond Apologies: What Men Can Do Now to Stop Sexual Harassment T.J. Iwashyna, MD, PhD, Ann Arbor, MI 4:00 Women in Critical Care: We Are Too Small a Minority H.B. Gershengorn, MD, ATSF, Miami, FL BASIC SCIENTIFIC SYMPOSIUM B89 UNLOCKING THE POTENTIAL OF TRAINED IMMUNITY TO TREAT RESPIRATORY INFECTION AND INFLAMMATION Assemblies on Allergy, Immunology and Inflammation; Critical Care; Pulmonary Infections and Tuberculosis; Respiratory Cell and Molecular Biology 2:15 p.m. - 4:15 p.m. Target Audience Pulmonary scientists seeking to gain novel insights into how trained immunity, a durable process of functional reprogramming of innate immune cells, may be modulated to promote lung or systemic homeostasis or reduce disease progression. Objectives At the conclusion of this session, the participant will be able to: • learn new findings about innate immune memory and its role in the host response to a secondary inflammatory or infectious stimulus. • apply knowledge on trained immunity to the design of future BASIC or translational investigations such as vaccine development and/or modulation of host responses to respiratory infection or sepsis. • define new strategies that have the potential to engage and integrate both the innate and adaptive immune systems for enhanced protection against infectious and inflammatory diseases. This symposium will provide the learner with a comprehensive introduction and overview of trained immunity in the context of respiratory and systemic inflammatory diseases. The aim is to explore how functional reprogramming of innate myeloid and lymphoid cell subsets could be used to modulate protective or pathological immune responses in the lung. The influence of trained immunity on systemic inflammatory diseases such as sepsis will also be discussed. Individual speakers will review the basic concepts and principles of innate immune memory, the crucial role of metabolic pathways in the functional reprogramming of myeloid and lymphoid cell types, and novel therapeutic approaches to modulate trained immunity. Chairing: S.T. Qureshi, MD, Montreal, Canada C. Dela Cruz, MD, PhD, ATSF, New Haven, CT A.E. Samarasinghe, PhD, Memphis, TN 2:15 Trained Immunity Mediates Adaptation of Hematopoietic Progenitor Cells to Inflammation G. Hajishengallis, DDS, PhD, Philadelphia, PA 2:35 Protection or Subversion of Hematopoietic Stem Cells During Mycobacterial Infection M. Divangahi, PhD, Montreal, Canada 2:55 Gamma Delta T Cells Play a Critical Role in Lung Recovery After Infant Infections P.G. Thomas, PhD, Memphis, TN 3:15 Trained Immunity of Alveolar Macrophages Enhances Resistance to Bacterial Pneumonia J.P. Mizgerd, ScD, ATSF, Boston, MA 3:35 Trained Immunity as a Defense Mechanism Against Sepsis in Neonates J.W. Wynne, MD, Gainesville, FL 3:55 Trained Innate Immune Protection Against Lethal Fungal-Bacterial Intra-Abdominal Infections M. Noverr, PhD, New Orleans, LA ATS 2020 • Philadelphia, PA MONDAY • MAY 18 93