ATS 2020 Advance Program

BASIC BASIC SCIENCE CORE B85 THE RARE AND THE FEW: NEWLY IDENTIFIED CELL TYPES IN THE LUNG AND IMPLICATIONS FOR DISEASE AND REGENERATION Assemblies on Respiratory Cell and Molecular Biology; Respiratory Structure and Function; Section on Genetics and Genomics 2:15 p.m. - 4:15 p.m. Target Audience Providers of lung health, and basic researchers. Objectives At the conclusion of this session, the participant will be able to: • learn new findings about the role of rare lung cells such as PNEC, ionocytes, tuft cells and interstitial macrophages in the pathophysiology of respiratory disease; • understand how genes associated with complex respiratory disease can be linked to specific cell types; • understand how different methods of single-cell sequencing can be applied to study pulmonary disease with development. With development of single-cell technologies our understanding of lung cellular heterogeneity is rapidly expanding. Several new lung cell types and previously poorly described states of know cells have been identified. The growing atlas of lung cells and their genetic fingerprints serves as an invaluable resource to understand changes of individual cells during development and their unique contributions to homeostasis. It also serves as baseline to study the spectrum of respiratory disease. Deciphering the cell states that emerge or expand following injury and tracking the cell-type specific responses during regeneration will greatly expand scientific and clinical understanding of lung biology. Chairing: E. Sajti, MD, PhD, San Diego, CA X. Sun, PhD, San Diego, CA 2:15 Pulmonary Neuroendocrine Cells and Asthma X. Sun, PhD, San Diego, CA 2:35 Ionocytes and Their Importance in the Pathogenesis of Cystic Fibrosis L. Wingert Plasschaert, PhD, Cambridge, MA 2:55 Anatomical and Functional Diversity of Lung Mesenchymal Cells, Implications for Homeostasis and Injury Repair After Exposure to Environmental Toxicant C. Kim, PhD, Boston, MA 3:15 Interstitial Macrophage Subsets and Their Role in Lung Fibrosis F. Ginhoux, PhD, Singapore, Singapore 3:35 Tuft Cells, the “Taste Bud” Cells of the Lung and Their Role in Reshaping Lung Tissue Structure in the Wake of Severe Influenza Pneumonia A. Vaughan, PhD, Philadelphia, PA 3:55 Pulse-Seq (Combining scRNA-seq and Lineage Tracing) and Other Emerging Single Cell Sequencing Methods to Understand Pulmonary Disease Y. Xu, PhD, Cincinnati, OH CLINICAL SCIENTIFIC SYMPOSIUM B86 DELIVERY OF PULMONARY REHABILITATION IN THE FACE OF SOCIAL AND HEALTH INEQUALITY: CAN WE BRIDGE THE GAP? Assemblies on Pulmonary Rehabilitation; Behavioral and Health Services Research; Environmental, Occupational and Population Health; Nursing 2:15 p.m. - 4:15 p.m. Target Audience Clinicians and rehabilitation practitioners managing patients with chronic respiratory disease, allied health care professions, health economists and sociologists. ATS 2020 • Philadelphia, PA 90 MONDAY • MAY 18