ATS 2020 Advance Program

NIAID SYSTEMS BIOLOGY OF ANTIMICROBIAL RESISTANCE L15 SYSTEMS BIOLOGY FOR ACUTE RESPIRATORY INFECTIONS 12:15 p.m. - 1:15 p.m. Target Audience Basic and translational researchers interested in a systems biology approach to antimicrobial-resistant pathogens and the host response to them. Objectives At the conclusion of this session, the participant will be able to: • learn how to apply a systems biology approach to studying infectious diseases outcomes; • define new strategies to combat antimicrobial resistant pathogens causing pneumonia. The NIH/NIAID uses a variety of mechanisms to support research on antimicrobial-resistance (AMR). A systems biology approach to AMR pathogens and diseases relevant to the pulmonary and critical care community will be illustrated. Chairing: L.L. Brown, PhD, Rockville, MD 12:15 NIAID’s Systems Biology Program in Infectious Diseases L.L. Brown, PhD, Rockville, MD 12:25 Influenza Virus-Host Interactions A. Garcia-Sastre, PhD, New York, NY 12:40 From Detection to Predicting Short- and Long-Term Infectious Disease Outcomes: Are Personalized Strategies Possible for Infectious Diseases? T. van Opijnen, PhD, Boston, MA 12:55 Successful Clinical Response in Pneumonia Treatment R.G. Wunderink, MD, Chicago, IL 1:10 Questions/Comments DIVISION OF LUNG DISEASES/NHLBI L16 THE LUNGAGING PROJECT: A SINGLE CELL MULTI-OMICS NORMAL LUNG AGING REFERENCE ATLAS 12:15 p.m. - 1:15 p.m. Target Audience Researchers, physicians, and vendors that are interested in molecular and cellular changes during aging process in the human lung and age-related lung diseases like COPD and IPF. Objectives At the conclusion of this session, the participant will be able to: • learn new findings in single-cell omics study of lung aging; • understand and learn the types of cells identified in lung by single-cell omics analysis; • learn how will the single-cell omics based lung aging program will enpower the discovery of cells causing lung diseases. Four speakers in this session are funded by NHLBI to investigate single-cell omics changes that cause lung function decline during the aging process in a healthy lung. They will present their current results and describe how to construct a lung aging map representing these dynamic changes at molecular and cellular levels in aging. Their results will shed light on normal lung aging, as well as the role of lung aging in the development of age-related lung diseases, such as COPD and IPF. Chairing: W. Gan, PhD, Bethesda, MD N. Kaminski, MD, New Haven, CT 12:15 Introduction of LungAging W. Gan, PhD, Bethesda, MD 12:23 Immunobiology and Alveolar Physiology of the Aging Lung D.L. Farber, PhD, New York, NY ATS 2020 • Philadelphia, PA MONDAY • MAY 18 81