ATS 2020 Advance Program

BASIC • BEHAVIORAL CLINICAL • TRANSLATIONAL SCIENTIFIC SYMPOSIUM D85 ENVIRONMENTAL EXPOSURES AND THE AIRWAY MICROBIOME Assemblies on Environmental, Occupational and Population Health; Allergy, Immunology and Inflammation; Behavioral and Health Services Research; Clinical Problems; Nursing; Pediatrics; Pulmonary Infections and Tuberculosis; Respiratory Cell and Molecular Biology 1:00 p.m. - 3:00 p.m. Target Audience Those interested in what modulates the microbiome, temporal dynamics versus stability of microbiome, how exposures disrupt microbiome homeostasis and cause disease, clinicians, researchers, educators, trainees interested in above will benefit. Objectives At the conclusion of this session, the participant will be able to: • understand how inhalation of a range of inhaled exposures can change the airway microbiome and/or change the airways microbiome’s influence on clinically relevant phenotypes; • appreciate how the airway microbiome determines the response to inhaled toxicants and/or may be manipulated for therapeutic purposes by inhaled interventions; • understand how diet can modify the microbiome’s response to inhaled exposures. Increasing evidence suggests that environmental and occupational inhalant exposures (indoor and outdoor air pollution, smoking, allergens, etc) can alter the airway microbiome. This may occur through several non-mutually-exclusive mechanisms: the inhalant acts directly as a vector for new organisms, changes airway microbiome through altered immunity, alters the airway’s structural defenses against the microbiome, changes how baseline (pre-existing) airway microbiome responds to inhaled stimuli, and/or acts via the lung-gut axis. This talk will dissect this evidence for these proposed mechanisms, consider modifying factors (sex, age, etc), and elucidate opportunities for preventive and therapeutic interventions. Doing so will identify key research gaps to fill in order to improve lung health. Chairing: C. Carlsten, MD, MPH, Vancouver, Canada I. Jaspers, PhD, Chapel Hill, NC C. Dela Cruz, MD, PhD, ATSF, New Haven, CT 1:00 A Patient’s Perspective Speaker To Be Announced 1:05 Traffic-Related Air Pollution, Host Defense, and Effects on the Airway Microbiome C. Carlsten, MD, MPH, Vancouver, Canada 1:24 E-Cigarettes’ Influence on the Upper Airway Microbiome I. Jaspers, PhD, Chapel Hill, NC 1:43 The Hygiene Hypothesis and the Microbiome of Airway Disorders E. von Mutius, MD, MSc, Muenchen, Germany 2:02 Airway-Relevant Cross-Talk Between the Exposome and the Microbiome H. Sbihi, PhD, Vancouver, Canada 2:21 Dietary Exposure and Host-Microbe Interactions: Impact on Respiratory Disease N. Ubags, PhD, Epalinges, Switzerland 2:40 The Microbial Gut-Lung Axis as a Key Mediator of Host Response to Environment P. Hansbro, PhD, Sydney, Australia BASIC • CLINICAL • TRANSLATIONAL SCIENTIFIC SYMPOSIUM D86 CUTTING-EDGE DIAGNOSTICS: INTEGRATING MULTI-OMIC PLATFORMS IN THE DIAGNOSIS OF LUNG INFECTIONS Assemblies on Pulmonary Infections and Tuberculosis; Allergy, Immunology and Inflammation; Critical Care; Section on Genetics and Genomics ATS 2020 • Philadelphia, PA WEDNESDAY • MAY 20 143