ATS 2020 Advance Program

8:45 Introduction to Translational Imaging in Pulmonary Hypertension N.C. Chesler, PhD, Madison, WI 9:05 Novel Approaches for Lungs and Right Heart Imaging in Pre-Clinical Pulmonary Hypertension B. Kojonazarov, MD, PhD, Giessen, Germany 9:25 Improved Understanding of Pulmonary Vascular Disease With Synchrotron-Based Phase Contrast Micro-CT K. Tran-Lundmark, MD, PhD, Lund, Sweden 9:45 Exploiting Positron Emission Tomography: A Potential Molecular Imaging Biomarker in Pulmonary Hypertension L. Zhao, MD, PhD, London, United Kingdom 10:05 Molecular Imaging of Pulmonary Vascular Disease Using Microvascular Endothelial Cell Ligands J. Dupuis, MD, PhD, Montreal, Canada 10:25 Imaging in Group 2 Pulmonary Hypertension M. Simon, MD, MS, Pittsburgh, PA BASIC • CLINICAL • TRANSLATIONAL SCIENTIFIC SYMPOSIUM D8 THE MATRIX REVEALED: UNDERSTANDING EXTRACELLULAR MATRIX INFLUENCES ON LUNG DISEASES Assemblies on Respiratory Structure and Function; Allergy, Immunology and Inflammation; Pulmonary Circulation; Pulmonary Infections and Tuberculosis; Respiratory Cell and Molecular Biology; Sleep and Respiratory Neurobiology 8:45 a.m. - 10:45 a.m. Target Audience Scientists and physician scientists who are interested in understanding how the extracellular matrix (ECM) guides cellular function in the lung, thereby influencing homeostasis and diseases. Objectives At the conclusion of this session, the participant will be able to: • identify opportunities for novel investigation into understudied aspects of lung matrix biology and cell-ECM interactions; • contrast the strengths and weaknesses of model systems and approaches recently developed to study lung ECM and cell-ECM interactions; • learn how advances in lung matrix biology are revealing new mechanisms of lung homeostasis and therapeutic targets to reduce/ reverse pathological remodeling. The extracellular matrix provides important cues that guide cellular function in the lung. Understanding how these cues emerge, change, and influence lung cell biomechanics will provide valuable insight into this fundamental but still under-studied aspect of lung biology. Talks from leading experts in this field will reveal how investigations using new technologies in cellular, tissue and animal model systems are delineating important roles for the matrix in lung repair and regeneration, during both health and diseases. Chairing: R. Krishnan, PhD, MS, Boston, MA J.K. Burgess, PhD, Groningen, Netherlands 8:45 Substrate Stiffness Is a Potent Epigenetic Cue of Fibroblast Biology D.J. Tschumperlin, PhD, Rochester, MN 9:05 ECM as a Driver of Progressive Fibrosis P.B. Bitterman, MD, Minneapolis, MN 9:25 Reconstructing the Lung Extracellular Matrix: Dream or Reality? R. Farre, PhD, Barcelona, Spain 9:45 Fungal Allergens Promote AHR by Disrupting ASM-ECM Interactions K. Druey, MD, Bethesda, MD 10:05 Does the ECM Stiffness or Organization Dictate Disrupted Repair in Chronic Lung Disease? J.K. Burgess, PhD, Groningen, Netherlands 10:25 Vascular Wall Stiffening Is a Major Contributor to Pulmonary Hypertension L.E. Fredenburgh, MD, Boston, MA ATS 2020 • Philadelphia, PA WEDNESDAY • MAY 20 129