ATS 2020 Advance Program

ATS 2020 • Philadelphia, PA 128 WEDNESDAY • MAY 20 • understand when to submit earlier referral of infants with lethal lung disorders for lung transplant evaluation. Congenital disorders of lung development encompass early diffuse interruptions of lung development (acinar dysplasia), to more focal abnormalities (CPAMs) and space occupying lesions (congenital diaphragmatic hernia) that can result in pulmonary hypoplasia. While rare, they are associated with substantial morbidity and mortality. Genetic and other molecular mechanisms underlying these disorders have been identified in recent years, ranging from single gene disorders, to more complex inheritance mechanisms and de novo and somatic mutations. This session will present current information concerning molecular mechanisms for developmental lung disorders, with an emphasis on molecular diagnostics and potential directions for novel therapeutic approaches. Chairing: J.A. Wambach, MD, MS, St. Louis, MO L.M. Nogee, MD, Baltimore, MD 8:45 Introduction L.M. Nogee, MD, Baltimore, MD 8:48 The Pathology of Normal and Abnormal Lung Development G. Deutsch, MD, Seattle, WA 9:05 Molecular Mechanisms of Acinar Dysplasia P. Stankiewicz, PhD, Houston, TX 9:25 The Evolving Spectrum of Alveolar Capillary Dysplasia J.A. Wambach, MD, MS, St. Louis, MO 9:45 Molecular Mechanisms of Congenital Lung Malformations E.E. Morrisey, PhD, Philadelphia, PA 10:05 The Genetics of Congenital Diaphragmatic Hernia W.K. Chung, MD, PhD, New York, NY 10:25 Lung Transplantation for Disorders of Lung Developmet C. Towe, MD, Cincinnati, OH BASIC • TRANSLATIONAL SCIENTIFIC SYMPOSIUM D7 SEEING IS BELIEVING: NOVEL IMAGING APPROACHES TO THE PULMONARY VASCULATURE AND RV Assembly on Pulmonary Circulation 8:45 a.m. - 10:45 a.m. Target Audience Basic scientists as well as clinicians working with pulmonary hypertension/pulmonary vascular disease. Objectives At the conclusion of this session, the participant will be able to: • learn about promising molecular imaging approaches in human disease and methodologies for characterizing pulmonary vascular remodeling and the RV, with a particular emphasis on the detection of early changes; • identify potential collaborators and resources to facilitate the incorporation of novel imaging approaches into their own research; • learn to apply new techniques in clinical practice. Tremendous progress has been made in the development of new imaging approaches to the pulmonary vasculature and right ventricle for research and clinical use. This session will explore how novel imaging techniques can enhance our understanding of the pathophysiology of pulmonary hypertension and provide useful biomarkers of disease diagnosis and prognosis. High-resolution and molecular imaging studies are very powerful tools for identifying the spatial distribution of molecular targets, making them an important complement to all types of OMICS. Speakers will present new ways to image pulmonary vascular remodeling and RV adaptation and failure in humans and in animal models. Chairing: W.M. Oldham, MD, PhD, Boston, MA R. Berger, MD, PhD, Groningen, Netherlands R.N. Channick, MD, Los Angeles, CA