ATS 2020 Advance Program

3:55 Cigarette Smoking and Pulmonary Vascular Injury N. Weissmann, PhD, Giessen, Germany BASIC • BEHAVIORAL CLINICAL • TRANSLATIONAL SCIENTIFIC SYMPOSIUM C88 ADVANCES IN RESPIRATORY DISEASES IN DOWN SYNDROME: BRIDGING BENCH AND BEDSIDE Assemblies on Pediatrics; Behavioral and Health Services Research; Clinical Problems; Respiratory Cell and Molecular Biology; Sleep and Respiratory Neurobiology 2:15 p.m. - 4:15 p.m. Target Audience Basic scientists, clinicians, student and postdoctoral trainees with an interest in the understanding of respiratory and pulmonary vascular disorders in Down Syndrome patients. Objectives At the conclusion of this session, the participant will be able to: • review the current understanding and provide latest updates in the respiratory challenges in DS patients; • improve knowledge of the various manifestations of lung disorders in DS patients; • improve understanding of the latest advances in basic and translational avenues into the pathophysiology underlying lung disease in DS. Infants and children with Down Syndrome have significant Pulmonary morbidity, yet very little is known about the underlying mechanisms that result in the pathophysiological changes. Recent insights hold the promise of new approaches to the management of children with Down Syndrome. Moreover, a recent multi-institutional funding initiative from the NIH Office of the Director seeks to facilitate fundamental, clinical and translational DS research. The ultimate goal of this initiative is to enable development of candidate therapeutics or diagnostics for comorbidities of DS, including respiratory disease. This session will evaluate recent progress made in understanding the pathophysiology, the genetic landscapes, diagnoses and therapeutic tools for respiratory diseases in Down Syndrome patients. Chairing: D. Al Alam, PhD, MS, Los Angeles, CA P.E. Moore, MD, ATSF, Nashville, TN T.J. Mariani, PhD, Rochester, NY 2:15 Overview of Respiratory Challenges in Down Syndrome Patients P.E. Moore, MD, ATSF, Nashville, TN 2:35 Pulmonary Vascular Disease in Children with DS E.D. Austin, MD, MSc, Nashville, TN 2:55 Cellular and Molecular Defects in Fetal Down Syndrome Lung D. Al Alam, PhD, MS, Los Angeles, CA 3:15 In Vivo Modeling Down Syndrome-Related Lung Developmental Disease and Pulmonary Hypertension C. Galambos, MD, PhD, Aurora, CO 3:35 Predictors and Trajectory of Sleep Disordered Breathing in Children with Down Syndrome S. Katz, MD, Ottawa, Canada 3:55 Patients and Politics K. Summar, MD, Washington, DC CLINICAL • TRANSLATIONAL SCIENTIFIC SYMPOSIUM C89 QUANTITATIVE PHYSIOLOGY: MODERN IMAGING TOOLS FOR TACKLING TIMELESS QUESTIONS Assemblies on Respiratory Structure and Function; Clinical Problems; Pulmonary Circulation 2:15 p.m. - 4:15 p.m. Target Audience Clinicians, basic scientists, translational researchers, fellows, residents and graduate trainees seeking to learn about novel imaging tools that provide new insights into cardiopulmonary physiology. ATS 2020 • Philadelphia, PA TUESDAY • MAY 19 119