ATS 2020 Advance Program

2:49 Understanding the Genetics of Individuals With Pulmonary Fibrosis More Important Than Profiling Their Individual Cells L.V. Wain, PhD, Leicester, United Kingdom 3:12 Insights From the IPF Cell Atlas N. Kaminski, MD, ATSF, New Haven, CT 3:34 We Don’t Need to Describe Every Tree to Understand the Forest: Telomere Attrition Is the Common Mechanism Driving Pulmonary Fibrosis M. Armanios, MD, Baltimore, MD 3:57 Mythbuster Summary 1 M.R.J. Kolb, PhD, MD, Hamilton, Canada 4:02 Mythbuster Summary 2 J.S. Lee, MD, Aurora, CO 4:07 Mythbuster Summary 3 Z. Borok, MD, ATSF, Los Angeles, CA 4:12 Vote to Uphold or Bust the Myth X. Yan, PhD, New Haven, CT BASIC • TRANSLATIONAL SCIENTIFIC SYMPOSIUM C87 PARTNERS IN CRIME: INTERACTION OF SEX DISPARITY, OBESITY, INFECTION AND SMOKING IN PULMONARY VASCULAR DISEASE Assemblies on Pulmonary Circulation; Allergy, Immunology and Inflammation; Environmental, Occupational and Population Health; Pulmonary Infections and Tuberculosis; Respiratory Cell and Molecular Biology; Respiratory Structure and Function 2:15 p.m. - 4:15 p.m. Target Audience Physicians, researchers and nurses from any field interested in learning about novel, state of the art research identifying the contributions of sex and environmental factors on the development of pulmonary vascular injury and Pulmonary Hypertension. Objectives At the conclusion of this session, the participant will be able to: • understand the interplay of sex, environment, and infection on pulmonary vascular disease; • learn new mechanisms implicated in pulmonary hypertension; • identify new potential avenues for personalized therapeutic interventions targeting multiple groups of pulmonary hypertension. Pulmonary Hypertension (PH) is a multifactorial pulmonary vascular disease that can arise spontaneously or as a complication of chronic pulmonary disease, left heart disease, or HIV infection. PH commonly leads to profound and refractory RV failure and death. Although sex, infection, and lifestyle risk factors (obesity, smoking) are associated with pulmonary vascular injury, the direct effects and interplay of these factors to the development of PH are complex and largely unknown. This session will discuss current and state of the art research identifying the contribution and interplay of lifestyle, infection, and sex to PH and pulmonary vascular disease. Chairing: A.L. Frump, MS, PhD, Indianapolis, IN S. Umar, MD, PhD, Los Angeles, CA Q. Lu, DVM, PhD, Providence, RI R. Paulin, PhD, Quebec, Canada 2:15 The Contribution of Sex Hormones and Sex Chromosomes in Pulmonary Hypertension M. Eghbali, PhD, Los Angeles, CA 2:35 Subcutaneous Adipose Tissue Is Associated with Presence of Pulmonary Hypertension N. Al-Naamani, MD, MS, Philadelphia, PA 2:55 Obesity-Induced Changes to Estrogen Metabolism in Pulmonary Arterial Hypertension M.R. MacLean, PhD, Glasgow, United Kingdom 3:15 HIV and Pulmonary Vascular Disease N.K. Dhillon, PhD, Kansas City, KS 3:35 Schistosomiasis and Pulmonary Vascular Disease G.S. Butrous, PhD, Canterbury, United Kingdom ATS 2020 • Philadelphia, PA 118 TUESDAY • MAY 19