ATS 2020 Advance Program

pathophysiology in the stable and setting of acute exacerbation of COPD, the impact of disordered pulmonary physiology on the exercise training response and the physiological significance of lung-heart interactions in COPD. The impact of lung/heart/muscle pathophysiology on exercise training and pulmonary rehabilitation will be explored throughout the symposium. Chairing: E. Barreiro, MD, PhD, Barcelona, Spain R. Evans, MBChB, PhD, Leicester, United Kingdom 9:15 A Patient’s Perspective S peaker To Be Announced 9:23 Metabolic Physiology of Skeletal Muscle in COPD: What Does It Tell Us About Pathophysiology? P. Greenhaff, PhD, Nottingham, United Kingdom 9:51 Acute Muscle Loss During Exacerbation of COPD: Why Does It Happen and How Do We Measure It? N.J. Greening, MBBS, PhD, Leicester, United Kingdom 10:19 Physiology of Exercise Training in COPD: Do We Need a Different Approach? T. Dolmage, MSc, Toronto, Canada 10:47 The Pressure Is On: Impact of Pulmonary Mechanics on Cardiac Function in COPD I. Vivodtzev, PhD, Boston, MA BASIC • TRANSLATIONAL SCIENTIFIC SYMPOSIUM C7 DECIPHERING THE ALVEOLAR PUZZLE: CELLS IN THE DISTAL LUNG DURING INJURY AND AGING Assemblies on Respiratory Cell and Molecular Biology; Critical Care; RCMB Aging Interest Group 9:15 a.m. - 11:15 a.m. Target Audience Basic and clinical researchers, clinicians, fellows, residents, and graduate students who are interested in the mechanisms of homeostatic and post-injury distal lung repair, and the implication of injury in lung aging. Objectives At the conclusion of this session, the participant will be able to: • understand the temporal and spatial molecular networks which have gone awry during sterile and non-sterile lung injury and aging; • understand the complex supportive cell network for the regeneration of the distal lung niche; • unify expertise in various biomedical fields: developmental biology, aging, pediatric and adult pulmonologists, geneticist, cell biologist, physiologists and -omics experts. The commonality between aging and lung diseases of unresolvable injuries (IPF and COPD) have been well-conceptualized. The study of various distal cell responses to homeostasis and aging could help us decipher the pathology beyond their response to injury. This session overviews the diverse responses of distal lung niche cells (e.g., epithelial, endothelial, mesoderm, and lymphoid cells) during development, injury repair, regeneration, and aging. The goal is to cross-examine newly obtained experimental data with an emphasis on distal lung progenitor cells (e.g. ATII cells) and the cross-talk with the supportive cells in the distal lung niche. This session aims to provide integrated perspectives for future research. Chairing: I. Rahman, PhD, ATSF, Rochester, NY K.A. Serban, MD, Denver, CO X. Zhao, MB, PhD, Norfolk, VA J.P. Bridges, PhD, Denver, CO 9:15 A Patient's Perspective Speaker To Be Announced 9:23 Temporal and Spatial Molecular Networks Orchestrate Alveolar Homeostasis and Response to Injury J.A. Whitsett, MD, Cincinnati, OH 9:51 Comparative Single-Cell RNAseq Insights on Distal Lung Cell Aging and Injury H. Schiller, PhD, Munich, Germany ATS 2020 • Philadelphia, PA 104 TUESDAY • MAY 19