ATS 2019 Virtual Final Program

BASIC • TRANSLATIONAL POSTGRADUATE COURSE CME Credits Available: 6.5 PG3 A RESEARCHER’S GUIDE TO INTEGRATING THE PULMONARY ‘OMICSVERSE R Pre-registration and additional fees required. Continental breakfast and box lunch included. Attendance is limited. Member: $350 In-Training Member: $200 Non-Member: $425 In-Training Non-Member: $300 : Registrants must bring a laptop to the course to view the course material. Assemblies on Allergy, Immunology and Inflammation; Environmental, Occupational and Population Health; Respiratory Cell and Molecular Biology; Respiratory Structure and Function; Section on Genetics and Genomics 8:00 a.m. - 4:00 p.m. KBHCCD Room D170/D172 (Level 1) Target Audience Lung researchers interested in applying and integrating ‘Omics-based approaches (e.g. transcriptomics, single cell, cistromics, proteomics, metabolomics) to study the lung, including endotype-based approaches to personalizing lung disease treatment Objectives At the conclusion of this session, the participant will be able to: • learn new findings and methods with respect to transcriptome and chromatin profiling-based approaches to studying diverse forms of lung disease, including the application and pros/cons of RNA-seq, single cell RNA-seq, PRO-seq and ATAC-seq; • understand how proteomics and metabolomics are being used to define disease phenotypes, biomarkers, and improve patient care; • apply and integrate ‘Omics-based approaches to study lung disease; This session will expose attendees to state of the art practical lectures on key ‘Omics-based methodologies that are transforming our approach to diagnosing, endotyping and treating lung disease. Included in this course will be sessions dedicated to methods for studying the transcriptome, including single cell approaches; ‘Omics based studies of gene regulation and the enhancerome, including ChIP-seq and ATAC-seq; and approaches to characterize the proteome and metabolome in the context of lung disease. After practical overviews of each of these key methods, leading experts will subsequently provide detailed examples of integrated studies in which diverse ‘Omics approaches have been applied together to yield key new insights about lung disease. Chairing: A.N. Gerber, MD, PhD, Denver, CO B.E. Himes, PhD, Philadelphia, PA R.S. Kelly, MPH, PhD, Boston, MA 8:00 Introduction: The Grand Challenge of Integrating ‘Omics Data to Define Endotypes in Lung Disease C.P. Hersh, MD, MPH, ATSF, Boston, MA 8:20 Harnessing the Power of RNA-seq to Study Lung Disease S.A. Gharib, MD, Seattle, WA 8:55 Riding the Single Cell Transcriptome to Discover New Cellular Phenotypes in the Lung T. Desai, MD, MPH, Stanford, CA 9:30 Break 9:45 Generating High Resolution Maps of Airway Enhanceromes with ChIP and GRO-seq A.N. Gerber, MD, PhD, Denver, CO 10:20 DNA Methylation in Lung Disease: Genomics and Gene Expression I.V. Yang, BS, PhD, Aurora, CO 10:55 Defining Open Chromatin Using ATAC-seq: Applications to Pulmonary Immune Responses D.N. Cook, PhD, Durham, NC 11:30 LUNCH 12:25 The Pulmonary Proteome: Tools and Implications C.H. Wendt, MD, Minneapolis, MN 1:00 The Applications of Metabolomics in the Study of Respiratory Disease R.S. Kelly, MPH, PhD, Boston, MA 1:35 Commonalities and Common Methods in Diverse ‘Omics Data: A Practical Guide to Analysis B.E. Himes, PhD, Philadelphia, PA 2:10 Break 2:30 COPD GWAS Meets Proteomics and Everything in Between R.P. Bowler, MD, PhD, Denver, CO 3:00 A Multipronged ‘Omics-Based ATAC to Define I-L13 Signaling in the Airway W. Eckalbar, PhD, San Francisco, CA 3:30 Integrating Genomics and the Transcriptome in Asthma: From Gene to Function B.A. Raby, MPH, MD, Boston, MA BEHAVIORAL • CLINICAL • TRANSLATIONAL POSTGRADUATE COURSE CME Credits Available: 7 PG4 FUNDAMENTALS OF WRITING SUCCESSFUL MENTORED CLINICAL RESEARCH GRANTS (FUND ME) R Pre-registration and additional fees required. Continental breakfast and box lunch included. Attendance is limited. Member: $400 In-Training Member: $250 Non-Member: $475 In-Training Non-Member: $350 : Registrants must bring a laptop to the course to view the course material. Assemblies on Behavioral Science and Health Services Research; Clinical Problems; Critical Care; Nursing; Pediatrics; Pulmonary Infections and Tuberculosis; Sleep and Respiratory Neurobiology; Thoracic Oncology; Members in Transition and Training Committee 8:00 a.m. - 4:00 p.m. KBHCCD Room C148 (Level 1) ATS 2019 • Dallas, TX FRIDAY • MAY 17 3 FRIDAY