ATS 2019 Virtual Final Program

510 IL-4R a Blockade with Dupilumab Prevents Both Obstructive and Restrictive Aspects of Lung Function Impairment in an HDM-Induced Asthma Mouse Model/ G. Scott, J. Allinne, A.J. Murphy, M.A. Sleeman, J.M. Orengo, Tarrytown, NY, p.A1056 511 High-Dimensional Mass Cytometry to Phenotype the Cellular Immune Response to Segmental Allergen Challenge/ N.R. Bhakta, J.M. Wang, S. Garudadri, K.M. Ansel, B. Antalek, C.P. Nguyen, P. Woodruff, San Francisco, CA, p.A1057 512 Transcriptomics of Atopy and Atopic Asthma in White Blood Cells from Children and Adolescents/ Y. Jiang, O. Gruzieva, T. Wang, E. Forno, N. Boutaoui, T. Sun, E. Acosta-Pérez, G. Canino, E. Melen, W. Chen, J.C. Celedon, Pittsburgh, PA, p.A1058 513 Epigenome-Wide Association Study Identifies Epigenetic Markers for Asthma and Rhinitis in Nasal Epithelial Cells/ C. Qi, Y. Jiang, I.V. Yang, E. Forno, T. Wang, J.M. Vonk, U. Gehring, J. Cardwell, E. Acosta-Perez, G. Canino, N. Boutaoui, W. Chen, J.C. Celedon, C.-J. Xu, G.H. Koppelman, Groningen, Netherlands, p.A1059 514 Nasal Methylation Panel Accurately Classifies Children by Atopy or Atopic Asthma/ E. Forno, T. Wang, C. Qi, Q. Yan, C. Xu, N. Boutaoui, Y.-Y. Han, D. Weeks, Y. Jiang, F. Rosser, J. Vonk, S. Brouwer, E. Acosta-Perez, A. Colon-Semidey, M. Alvarez, G. Canino, G.H. Koppelman, W. Chen, J.C. Celedon, Pittsburgh, PA, p.A1060 515 Interferon Response Genes in Nasal Epithelium to Rhinovirus16 Challenge in Asthma Patients Links to Viral Clearance and Common Cold Scores/ A. Ravi, M. Chang, M.A. Van De Pol, S. Yang, A. Aliprantis, B. Thornton, J.M. Hohlfeld, P.J. Sterk, N. Krug, R. Lutter, Amsterdam, Netherlands, p.A1061 516 Detection of a Persistent Rv16 Infection Signature in Stable Neutrophilic Moderate to Severe Asthmatic Patients in the U-BIOPRED Cohort/ S. Pavlidis, Y. Guo, S. Mumby, R. Lutter, P.J. Sterk, R. Djukanovic, S.-E.K. Dahlen, K.F. Chung, I.M. Adcock, London, United Kingdom, p.A1062 517 Effect of In Utero Smoke Exposure on MicroRNA Expression in Human Lung Development/ S. Sharma, C. Liu, A.T. Kho, R. Gaedigk, C.A. Vyhlidal, K.G. Tantisira, K. Kechris, S.T. Weiss, Aurora, CO, p.A1063 518 Differential Global Methylation and Transcriptomic Patterns of Atopic Mothers Impact the Susceptibility of the Development of Atopy in Infants/ M. Schedel, P. Hauk, S. Leach, M. Strand, T. Danhorn, A. Faino, D.A. Schwartz, E.W. Gelfand, Denver, CO, p.A1064 519 Individual Gene Expression Signatures in Severe Asthmatics Identify Responders and Non-Responders to Imatinib/ D. Foer, S.H. Baek, K.N. Cahill, E. Israel, J. Cui, S.T. Weiss, A. Sharma, J.A. Boyce, Boston, MA, p.A1065 520 Linking Gene Signatures with Eosinophil Cell Counts Thresholds for Severe Asthma Endotypes, from Bronchial to Blood/ Y. Liu, W. Xue, D. De Sousa, D. Delic, R. Djukanovic, K.F. Chung, P.J. Sterk, I.M. Adcock, S.-E.K. Dahlen, S.J. Fowler, D. Shaw, A. Sousa, Ridgefield, CT, p.A1066 521 Genetic Risk Factors for Asthma Age of Onset Implicate Epithelial Barrier Dysfunction and Innate Immune Genes in Earlier Onset Asthma/ N. Schoettler, M. Pividori, D.L. Nicolae, H.K. Im, C. Ober, Chicago, IL, p.A1067 522 Replacement of Fetal-Derived with Bone Marrow-Derived Pulmonary Resident Macrophages Reduces House Dust Mite-Induced Airway Hyperresponsiveness/ Y.R.A. Yu, J. Daly, S.-L. Phelan, R.I. Cumming, A. Birukova, Y. Malakhau, J.L. Ingram, M.D. Gunn, L.G. Que, R.M. Tighe, Durham, NC, p.A7297 523 Selective Small Molecule STAT3 Inhibitor to Treat Eosinophilic and Neutrophilic Asthma in Mice/ J.R. Flores Gonzalez, T.K. Eckols, M.J. Tuvim, B.F. Dickey, D.J. Tweardy, Houston, TX, p.A7298 BEHAVIORAL • CLINICAL RAPID: RAPID ABSTRACT POSTER DISCUSSION SESSION A22 FACILITATING PALLIATIVE AND END-OF-LIFE CARE 9:15 a.m. - 11:15 a.m. KBHCCD Ballroom D Three (Level 3) Abstract Summaries 9:15-9:45 Viewing/Discussion 9:45-11:15 Chairing: A.S. Iyer, MD, Birmingham, AL A.E. Turnbull, DVM, MPH, PhD, Baltimore, MD J. Hart, MD, MS, Philadelphia, PA 601 Facilitators and Barriers of High-Quality Community Based Palliative Care (CBPC): Perspectives of Chronic Obstructive Pulmonary Disease (COPD) Patients and Their Caregivers/ K. Hyden, H. Coats, P.M. Meek, Aurora, CO, p.A1068 602 Integrating Screening and Referral to Palliative Care on Hospital Discharge Improves Symptom Scores in Patients with Severe COPD/ K.R. Prendecki, I.R. Allon, S. Klinger, K. Roy, Watford, United Kingdom, p.A1069 603 Palliative Care Use Around the Time of Chronic Obstructive Lung Disease Hospitalization Among Persons with Chronic Obstructive Lung Disease in Ontario, Canada/ L.C. Maclagan, N. Liu, P. Tanuseputro, T. A. Stukel, J. Guan, T. Kendzerska, M.S. Stefan, P.K. Lindenauer, A.S. Gershon, Toronto, Canada, p.A1070 604 Predictors and Implications of End of Life Care in Individuals with Respiratory Diseases, COPD Versus Lung Cancer: A Population-Based Study/ T. Kendzerska, J. Nickerson, A.T. Hsu, A. Gershon, R. Talarico, S. Mulpuru, S. Pakhale, P. Tanuseputro, Ottawa, Canada, p.A1071 605 The Association of Palliative Care with Indicators of Quality Cancer Care Among Patients with Advanced-Stage Lung Cancer/ K. Vranas, B. Chan, C.G. Slatore, D.R. Sullivan, Portland, OR, p.A1072 606 Elements of Specialist Palliative Care Among Patients with Advanced Stage Lung Cancer/ D.R. Sullivan, L. Ganzini, K.C. Vranas, C.G. Slatore, Portland, OR, p.A1073 ATS 2019 • Dallas, TX SUNDAY • MAY 19 35 SUNDAY MORNING